Last update 11 Jul 2024

Labetuzumab govitecan

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
Anti-CEA monoclonal antibody, Anti-carcinoembryonic antigen monoclonal antibody, Labetuzumab-SN38 conjugate
+ [5]
Mechanism
CEACAM5 antagonists(Carcinoembryonic antigen related cell adhesion molecule 5 antagonists), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-

Structure

Molecular FormulaC22H20N2O5
InChIKeyFJHBVJOVLFPMQE-QFIPXVFZSA-N
CAS Registry86639-52-3
View All Structures (2)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Colonic CancerPhase 2
US
12 Feb 2013
Metastatic Colorectal CarcinomaPhase 2
US
12 Feb 2013
Rectal CancerPhase 2
US
12 Feb 2013
Colorectal cancer recurrentPhase 2
US
01 May 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
86
(lskrpiitwv) = neutropenia (16%),leukopenia (11%),anemia (9%),diarrhea (7%) ixwddagpfv (xrfuqefpnn )
Positive
10 Oct 2017
Phase 2
86
(mrbcikigse) = fxuapcckur qmzkaojxeb (fcwdhrpbge )
Positive
15 Jul 2016
(mrbcikigse) = tcnayxahpq qmzkaojxeb (fcwdhrpbge )
Phase 1/2
66
(eaoqimxwrq) = iyvyrfopuh dhwgqeffue (hfkobgkont )
-
20 May 2015
Phase 1
9
cqutvhiept(jvfvnrskkk) = avqvrhfgrd sxwsapxcrr (nrlqbgzweg )
-
15 Apr 2013
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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