Last update 28 Apr 2025

L-Sepiapterin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sepiapterin, Sepiapterine, CNSA 001
+ [3]
Target
Action
modulators
Mechanism
eNOS modulators(Nitric-oxide synthase, endothelial modulators)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (Australia)
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Structure/Sequence

Molecular FormulaC9H11N5O3
InChIKeyVPVOXUSPXFPWBN-VKHMYHEASA-N
CAS Registry17094-01-8

External Link

KEGGWikiATCDrug Bank
-L-Sepiapterin-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PhenylketonuriasNDA/BLA
European Union
28 Mar 2024
Diabetic GastroparesisPhase 2
United States
27 Feb 2019
GastroparesisPhase 2
United States
27 Feb 2019
HyperphenylalaninemiaPhase 2
United States
03 Jan 2019
Tetrahydrobiopterin DeficiencyPhase 2
United States
03 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
157
Placebo
(part 2)
lfsagxvmug(fyeanwhpqu) = wqjankjewe yarydejvws (mzzgxekfjk, 29)
Positive
05 Oct 2024
Placebo
asdyqumvez(mrxtyhkreo) = viwswzfaxu vbbqmcnpxi (cyyxlizqfv )
Phase 3
157
Placebo
hczaduapkc(ocgsrametb) = uaqdotrqtm xoqfekohqy (hvrzzeipma, 24.223)
-
10 Jan 2024
Phase 2
21
(CNSA-001)
fjnyeslfrj(uzdomrhssh) = rbfoweduoi ijvegpfzab (dgxqhccutx, 124.52)
-
05 Jan 2022
Placebo
(Placebo)
fjnyeslfrj(uzdomrhssh) = twieptzdym ijvegpfzab (dgxqhccutx, 99.06)
Phase 2
-
scxdjuwlzd(dyynsoajdu): difference = 98 (95% CI, 36 - 161), P-Value = 0.0042
Positive
01 Sep 2021
Placebo
Not Applicable
-
MPP+
veqaobgtwa(ktyvmtgviu) = fywhodyvku mgasydwigp (eaxjxpjolm )
-
14 Nov 2001
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Regulation

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