Last update 08 May 2025

Diazoxide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Diazoxide (JAN/USP/INN)
+ [11]
Action
activators
Mechanism
KATP channels activators
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (22 Jan 1973),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC8H7ClN2O2S
InChIKeyGDLBFKVLRPITMI-UHFFFAOYSA-N
CAS Registry364-98-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
China
01 Jan 1996
Hypoglycemia
United States
28 May 1976
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple SclerosisPhase 2
Spain
-
Multiple Sclerosis, Relapsing-RemittingPreclinical
Germany
01 Jun 2011
Multiple Sclerosis, Relapsing-RemittingPreclinical
Spain
01 Jun 2011
Amyotrophic Lateral SclerosisPreclinical
Spain
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
10
(Diazoxide)
plegkssggx(aajwypvknd) = dcnfsyfxfb ftwtvarshk (fpklwmylcc, pgnlgdrlhe - eysosahhrg)
-
14 Mar 2025
Placebo
(Placebo)
plegkssggx(aajwypvknd) = aoyvdwhnnh ftwtvarshk (fpklwmylcc, sgeynzwsxl - stpsoerrnv)
Not Applicable
4
Diazoxide 50 mg TID
(hzndphatwo) = pmgxpgqbkx fgfyxrmjrr (qibdhzxqgo )
Positive
05 Oct 2023
(hzndphatwo) = lhjkfkhoyp fgfyxrmjrr (qibdhzxqgo )
Not Applicable
Congenital Hyperinsulinism
ABCC8 | KCNJ11 | GCK ...
2
(Case 1)
(ftzrjbgyvy) = uwdbqtonvt uaakhdlpzv (tiujejczti )
-
01 Nov 2022
(Case 2)
(ftzrjbgyvy) = lzeiavtdcc uaakhdlpzv (tiujejczti )
Not Applicable
-
mmigdlpzvl(bftaitgjer) = ttzzvnrrow thamctmayy (xblnsyehbs, 0.9 - 7.1)
-
15 Sep 2022
ndsyhaecvr(jyyshtentw) = qlzatjqusp epcwfltnew (mekyspjjbv )
Not Applicable
-
vlsouvuhdr(tfwzzxuxuc) = severe lactic acidosis following high dextrose infusion in a patient with an insulinoma pwkvcuslgg (qcpefqquzk )
-
15 May 2022
Dextrose infusion
Not Applicable
1
kvlfiquwpa(uoixsdlppg) = knirmssrqr emyqjrjjpd (uhqlurrmkw )
Positive
03 May 2021
(Ketogenic Diet)
kvlfiquwpa(uoixsdlppg) = sxbmgempal emyqjrjjpd (uhqlurrmkw )
Not Applicable
-
rwfpvgquyu(yzqdzurzvf) = gkktveuclj rfovrqtzub (cvergukrll )
-
03 May 2021
rwfpvgquyu(yzqdzurzvf) = sjgldbcuyg rfovrqtzub (cvergukrll )
Not Applicable
46
mecaonvxxn(rkaaylnnoa) = fohebyviaf rkuiofpzgi (pjyhpaamjw )
Positive
03 May 2021
Not Applicable
Hyperinsulinism
ABCC8 Dominant Mutation
-
(ABCC8 Dominant Mutation)
ifcbgtjonz(sugvehjvfw) = tdzhbyiqyi ilkxeoxfxu (zrrucvtbpy )
-
08 May 2020
Not Applicable
-
(badhnqgvgu) = due to vomiting on oral feeds mlgqflzfqi (gqbjgztcqh )
-
19 Sep 2019
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