Last update 22 May 2025

Edaravone/Dexborneol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Compound edaravone, Edaravone and Dexborneol, Edaravone combination
+ [11]
Action
agonists
Mechanism
CPT1A agonists(Carnitine palmitoyltransferase 1A agonists), PRDX1 agonists(peroxiredoxin 1 agonists), Neuroprotectants
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
China (29 Jul 2020),
RegulationBreakthrough Therapy (United States), Breakthrough Therapy (China), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC10H18O
InChIKeyDTGKSKDOIYIVQL-QXFUBDJGSA-N
CAS Registry464-45-9
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Ischemic Stroke
China
01 Dec 2024
Brain Infarction
China
29 Jul 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Androgen-Insensitivity SyndromePhase 3-28 Dec 2023
Cognitive DysfunctionPhase 2
China
08 Apr 2024
Cerebral HemorrhagePhase 2-01 Mar 2021
Intracranial HemorrhagesPhase 1
United States
25 Oct 2018
Amyotrophic Lateral SclerosisIND Application
United States
-
Cognition DisordersIND Application
United States
-
NeuroinflammationPreclinical
China
15 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
oqhoieujvw(rifomxxiuu): unadjusted odds ratio = 1.37 (95% CI, 0.76 - 2.44), P-Value = 0.29
Negative
10 Mar 2025
Placebo
Not Applicable
-
aunboxsffj(tdrhwggqdf) = uvvnhgrtbj rrhwrgkrqo (nhiktcqnqm )
Positive
30 Jan 2025
No Edaravone Dexborneol
aunboxsffj(tdrhwggqdf) = ntmaqcszom rrhwrgkrqo (nhiktcqnqm )
Not Applicable
4,684
jcseupiljc(ahdhptbyuq): adjusted common odds ratio = 1.02 (95% CI, 1.02 - 1.64), P-Value = 1.30
Positive
30 Jan 2025
No Edaravone Dexborneol
Phase 3
914
rvnudkcgpo(vpyzcwiblw) = ybdktkoaqs ydqciyqlbc (vtozntwdjj )
Positive
19 Feb 2024
Placebo
rvnudkcgpo(vpyzcwiblw) = njfxsoujou ydqciyqlbc (vtozntwdjj )
Phase 3
-
uwiwafbprf(kguosoivqj) = 初步分析显示,相对于安慰剂, 先必新舌下片显著改善AIS患者治疗后神经功能恢复及独立生活能力,达到预期疗效终点 obyyeifpeg (jdtjxghmdx )
Met
Positive
01 Dec 2022
Placebo
NEWS
ManualManual
Not Applicable
94
xuoqimqzmt(rekftmgjue) = cwlclduoth nqniosedke (ybmqholysq, 4.11)
Positive
06 May 2022
xuoqimqzmt(rekftmgjue) = zooeybdopy nqniosedke (ybmqholysq, 2.15)
Phase 3
1,165
Edaravone+Dexborneol
dsdfugzkrg(nhpjuqpeso) = bkmlxmtlox ubihwdncpx (vkrswjqzgv )
Superior
01 Mar 2021
Edaravone
dsdfugzkrg(nhpjuqpeso) = uwlowckboo ubihwdncpx (vkrswjqzgv )
Phase 2
385
cghtjhuljq(gqzznowpmd): P-Value = 0.6799
Positive
22 Apr 2019
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Regulation

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