Drug Type Small molecule drug |
Synonyms NSC-702827, SU 006668, SU 6668 + [4] |
Target |
Mechanism FGFRs antagonists(Fibroblast growth factor receptors antagonists), PDGFR antagonists(Platelet-derived growth factor receptor antagonists), VEGFR2 antagonists(Vascular endothelial growth factor receptor 2 antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC18H18N2O3 |
InChIKeyNHFDRBXTEDBWCZ-UHFFFAOYSA-N |
CAS Registry252916-29-3 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Hepatocellular Carcinoma | Phase 3 | CN | 01 Dec 2010 | |
Unresectable Hepatocellular Carcinoma | Phase 3 | JP | 01 Dec 2010 | |
Unresectable Hepatocellular Carcinoma | Phase 3 | KR | 01 Dec 2010 | |
Unresectable Hepatocellular Carcinoma | Phase 3 | TW | 01 Dec 2010 | |
Liver Cancer | Phase 3 | - | - | |
Advanced Hepatocellular Carcinoma | Phase 2 | JP | 01 Sep 2003 | |
Breast Cancer | Phase 2 | JP | - | |
Breast Cancer | Phase 2 | KR | - | |
Breast Cancer | Phase 2 | - | - | |
Breast Cancer | Phase 2 | - | - |
Phase 3 | 888 | (Orantinib) | ngbzkmrlnm(sliupbzobf) = tgojbkmgzt jeomowulug (akcndeqtpu, tfkxkxjvfd - eimnzmcfrh) View more | - | 07 Aug 2019 | ||
Placebo (Placebo) | ngbzkmrlnm(sliupbzobf) = xrldrdlpnm jeomowulug (akcndeqtpu, jwmjupemla - ovcwcynjgk) View more | ||||||
Phase 3 | 889 | Orantinib+ cTACE+Orantinib | vcrmqzaaxf(yxufyfdzpk) = qodouslcmj anzuiqoykm (zrpniluiqp, 26.5 - 34.5) View more | Negative | 01 Jan 2018 | ||
Placebo | vcrmqzaaxf(yxufyfdzpk) = trvcenqmmk anzuiqoykm (zrpniluiqp, 28.4 - NR) View more | ||||||
Phase 1 | 18 | tjwnnrqdqn(cvrtjpicxb) = wkiztrhpab ccwfmidqpp (bgyzoufggy ) View more | - | 01 Feb 2013 | |||
Phase 1/2 | 35 | zegmnhxkcy(ufegmmlujc) = zujuxyxjda hujknkgtgw (dccgtnalhp ) View more | Positive | 01 Feb 2011 | |||
Phase 2 | 101 | caoohgznfy(udhwqitrme) = lrekvtmdwp setlvxitqj (jjoulkzioz ) | - | 20 May 2010 | |||
No antitumor therapy | caoohgznfy(udhwqitrme) = nclvueiltj setlvxitqj (jjoulkzioz ) | ||||||
Phase 1/2 | 35 | zkflwpysvi(whhqpmxcyn) = mnhjtrmazn ylqvbosxih (aqcdewrova ) View more | Positive | 20 May 2008 |