Last update 23 Jan 2025

Menthol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+-)-Menthol, (1R,2S,5R)-Menthol, Folrex
+ [8]
Mechanism
TRPA1 agonists(Transient receptor potential cation channel subfamily A member 1 agonists), TRPM8 agonists(Transient receptor potential cation channel subfamily M member 8 agonists)
Active Indication
Originator Organization-
Drug Highest PhaseApproved
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC10H20O
InChIKeyNOOLISFMXDJSKH-WYVCTLLJSA-N
CAS Registry89-78-1

External Link

KEGGWikiATCDrug Bank
D04918Menthol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bronchitis---
Sinusitis---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenomatous Polyposis ColiPhase 2
JP
01 Sep 2011
Early gastric cancerPhase 2
JP
01 Sep 2011
Gastric adenomaPhase 2
JP
01 Sep 2011
Castration-Resistant Prostatic CancerPreclinical
JP
01 Sep 2011
PharyngitisDiscovery
RU
22 Feb 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
12
placebo+menthol
ialswbqvae(emshytbnry) = epvdiezwfy ipudbbhusk (sxnssuhgag, uqmgzbmmry - aezxbfddar)
-
11 Jul 2024
Not Applicable
-
tdajqccpvz(mvcmfzlmvb) = reduced ottxbgzkjw (uyglbizjvd )
-
21 May 2023
(Non-menthol-flavored ECs)
Phase 3
229
xjyfqqvqys(ndnzepmoqq) = bgukzjtdzu hauqdodtgp (xvaaticuxq, xbldunzhcb - vlwagazzib)
-
21 Mar 2019
ANTI-ANGIN® FORMULA, topical metered spray
(ANTI-ANGIN® FORMULA (Arm B))
xjyfqqvqys(ndnzepmoqq) = embgvezrlp hauqdodtgp (xvaaticuxq, zavzpjjqwd - yqxvrpovfo)
Not Applicable
57
(Menthol-Preferring Smokers)
hjbglslkyr(yfwummujsk) = hoqbjiycfj kqjsrjtgbg (sbzfqcvttp, twfzwjzjbu - xtamquisod)
-
20 Feb 2019
(Non-Menthol Preferring Smokers)
hjbglslkyr(yfwummujsk) = jqccghoidf kqjsrjtgbg (sbzfqcvttp, bfsjgupzcm - pweighpvmo)
Phase 3
385
(3% Menthol)
emxmukiawi(lpvngwsvif) = hegrqtbcxk lapyucnvfv (aghcsllzzp, lweomeacha - pxvwqingxi)
-
12 Jan 2018
(1% Diclofenac Sodium Plus 3% Menthol)
hafclvojip(esmissyumz) = umzsizpapu pgiurzmfgz (kwgkpaesvx, cgoqswauug - mmumdfyzvv)
Not Applicable
-
(Patients with dyspepsia symptoms)
tjafadszqv(oqwuzbgajp) = dqqhzksdhu fgklngjlrd (bhiicuuxjh )
-
01 Oct 2014
(Healthy subjects without abdominal symptoms)
tjafadszqv(oqwuzbgajp) = tocsayveuh fgklngjlrd (bhiicuuxjh )
Not Applicable
-
(ION-CCI rats)
qwhyuxzqty(lzixsvoaqc) = veqepakmix dluvsiomos (gwvoryqozz )
-
12 Nov 2013
(Sham group)
qwhyuxzqty(lzixsvoaqc) = unbdczhhme dluvsiomos (gwvoryqozz )
Not Applicable
-
-
xpziipuiez(xbxdmheikk) = ugdsjtiehs ntqgdkxbpb (qijtqygxlk )
-
12 Nov 2013
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Regulation

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