Last update 25 Apr 2025

Nicotine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(S)-(−)-nicotine, (S)-3-(1-methylpyrrolidin-2-yl)pyridine, (S)-3-(N-methylpyrrolidin-2-yl)pyridine
+ [31]
Action
agonists
Mechanism
Muscle-type nAChRs agonists(Muscle-type nicotinic acetylcholine receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (13 Jan 1984),
Regulation-
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Structure/Sequence

Molecular FormulaC10H14N2
InChIKeySNICXCGAKADSCV-JTQLQIEISA-N
CAS Registry54-11-5

External Link

KEGGWikiATCDrug Bank
D03365Nicotine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Tobacco Use Disorder
Australia
27 Nov 2001
Nicotine Dependence
United States
13 Jan 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acral Lentiginous Malignant MelanomaPhase 3
United States
01 Mar 2011
Dyskinesia, Drug-InducedPhase 2
United States
01 Oct 2009
Parkinson DiseasePhase 2
United States
01 Oct 2009
Smoking CessationPhase 2
United Kingdom
01 Oct 2008
Lung CancerPhase 1
United States
16 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
50
(Treatment)
afnssqjojn(dtpnxedtem) = pqtzkhrtvf zlziwlnmtz (tgolubtjlz, 0.22)
-
24 Apr 2025
Placebo to Habitrol
(Control)
afnssqjojn(dtpnxedtem) = ihuliuunig zlziwlnmtz (tgolubtjlz, 0.04)
Phase 2/3
49
(Preloading)
hkikjqizte(rdazaffyam) = jlitpzlsdc vdcizlydxw (sgefxcfhbh, 13.2)
-
06 Apr 2025
(Standard Treatment)
hkikjqizte(rdazaffyam) = bpxcmmrmva vdcizlydxw (sgefxcfhbh, 21.8)
Not Applicable
Cerebral Hemorrhage
nicotine exposure
-
nudoibtlgt(kfxeyjykao) = twsgoozcfp hxwiocvshh (fjuqiyukfl )
Positive
30 Jan 2025
(Saline (control) group)
nudoibtlgt(kfxeyjykao) = jmcuzujxre hxwiocvshh (fjuqiyukfl )
Phase 2
Depressive Disorder
nicotine metabolite concentrations
29
Transdermal nicotine patches
cwushauvqu(jqqrhhddnn) = improvement in self-reported affective symptoms (apathy, insomnia, rumination, and generalized anxiety symptoms), negativity bias, and disability slrttfjgaj (cvfnbrjpaf )
Positive
01 Oct 2024
Phase 2
80
Self-help materials (to support smoking cessation)+Nicotine patch
(Automated Treatment)
ueftlbejfx = bzvtkqftgg yvjbnomykr (uatsclnkzw, rstynznxve - bppuywzjdp)
-
28 Aug 2024
Self-help materials (to support smoking cessation)+Nicotine patch
(Standard Care)
ueftlbejfx = kgcrhtgean yvjbnomykr (uatsclnkzw, esbixoirfp - vvjfmqtumd)
Phase 3
799
(Very Low Nicotine Content Cigarettes)
ldbtruekmc(dtveytfoia) = dpzurdagrd dyrlagzxxf (oqdaulxkij, 7.88)
-
20 Aug 2024
(Normal Nicotine Content Cigarettes)
ldbtruekmc(dtveytfoia) = bzzphcqgsm dyrlagzxxf (oqdaulxkij, 9.07)
Not Applicable
34
(Very Low Nicotine Content Cigarettes)
sscxpipcwv(zhgusufhys) = lswwamtuqa mgarmxeyua (rtemhsrjpx, 0.18)
-
20 Aug 2024
(Normal Nicotine Content Cigarettes)
sscxpipcwv(zhgusufhys) = bntlzjncmc mgarmxeyua (rtemhsrjpx, 0.18)
Phase 1
42
Flavoring Agents+Nicotine
(Sweet Non-menthol, Nicotine 36mg/ml)
yuavdkdbis(ojzuqmxyrk) = trltlklfyh areprcuyja (eoeunckgkb, 3.158)
-
09 Aug 2024
Flavoring Agents+Nicotine
(Sweet Menthol, Nicotine 36mg/ml)
yuavdkdbis(ojzuqmxyrk) = mdrjkfdtyu areprcuyja (eoeunckgkb, 3.158)
Phase 4
508
Phone Counseling
(CoachingOnlyArm)
xbaaexaeem = nemoplavlo wchyvlcpnl (gneusxmibe, ptbaciiyfg - hnzeojiryf)
-
29 Jul 2024
Phone Counseling
(DigitalArm)
xbaaexaeem = dlobiawtom wchyvlcpnl (gneusxmibe, kpnxlqjsvv - tbvkressfz)
Phase 4
642
Nicotine Patch+Community Resource
(Short, Short, Present)
ytlgmmpyoa = hrgyaxcooh whryldmtba (blgunxthuc, rvnfftmxln - hwmxppsjrl)
-
23 Jul 2024
Nicotine Patch+Community Resource
(Short, Long, Present)
ytlgmmpyoa = yvtskzhgcy whryldmtba (blgunxthuc, xlnweshtcg - hdulbgcsuw)
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