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Last update 29 Sep 2025
Nilvanstomig
Last update 29 Sep 2025
Overview
Basic Info
Drug Type Bispecific antibody |
Synonyms ZG-005, ZG005 |
Target |
Action inhibitors |
Mechanism PD-1 inhibitors(Programmed cell death protein 1 inhibitors), TIGIT inhibitors(T cell immunoglobulin and ITIM domains inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
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Related
21
Clinical Trials associated with NilvanstomigCTR20252686
ZG005 联合盐酸吉卡昔替尼片在晚期宫颈癌患者中的多中心、开放、剂量探索和剂量扩展的I/II 期临床研究
[Translation] A multicenter, open-label, dose-finding and dose-expansion phase I/II clinical study of ZG005 combined with gecaxitinib hydrochloride tablets in patients with advanced cervical cancer
NCT07142837
A Study to Evaluate the Efficacy and Safety of ZG005 in Combination With Gecacitinib and Chemotherapy for Participants With Advanced Solid Tumors
NCT07099547
A Study to Evaluate the Efficacy and Safety of ZG005 in Combination With Platinum-Based Chemotherapy as First-Line Treatment in Participants With Advanced Biliary Tract Carcinoma
100 Clinical Results associated with Nilvanstomig
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100 Translational Medicine associated with Nilvanstomig
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100 Patents (Medical) associated with Nilvanstomig
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100 Deals associated with Nilvanstomig
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced Lung Small Cell Carcinoma | Phase 2 | China | 04 Sep 2025 | |
| Biliary Tract Neoplasms | Phase 2 | China | 01 Sep 2025 | |
| Gallbladder Neoplasms | Phase 2 | China | 01 Sep 2025 | |
| Neuroendocrine Carcinoma | Phase 2 | - | 01 Aug 2025 | |
| Small Cell Lung Cancer | Phase 2 | - | 01 Aug 2025 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | China | 01 May 2025 | |
| Recurrent Lymphoma | Phase 2 | China | 28 Apr 2025 | |
| Refractory Lymphoma | Phase 2 | China | 28 Apr 2025 | |
| Advanced Lung Non-Small Cell Carcinoma | Phase 2 | China | 01 Apr 2025 | |
| Advanced biliary tract cancer | Phase 2 | China | 04 Mar 2025 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1/2 | Advanced Cervical Carcinoma First line | 41 | gkriulkaua(xjhrsvuawk) = 1 SAE of bilateral lung pneumonia in the 10 mg/kg group was assessed related to ZG005 by the investigator enkwykctsd (azxcihvlgj ) | Positive | 30 May 2025 | ||
Not Applicable | 55 | ieajaxlmao(pqbxwklste) = Serious adverse events (SAEs) occurred in 8 subjects (14.5%), with one myositis case (1.8%) was the only SAE related to ZG005 and also the sole TRAE that led to treatment discontinuation kybcngjxow (bxoymuxoba ) View more | Positive | 30 May 2025 | |||
CTR20220021 (NEWS) Manual  | Phase 1/2 | 46 | iwfjgdoats(ifqrrcqapi) = sseepfuxwv bxjjtwozxz (nlxigcwrpa ) View more | Positive | 25 Sep 2024 | ||
(20 mg/kg) | iwfjgdoats(ifqrrcqapi) = tgavbehpng bxjjtwozxz (nlxigcwrpa ) View more | ||||||
Not Applicable | Advanced Hepatocellular Carcinoma First line | 10 | issdmqzgxr(riydnhicgg) = dnlihddehw lghiaxjbtj (jssjcsvfch ) View more | Positive | 25 Sep 2024 | ||
CTR20220021 (ASCO2024) Manual | Phase 1 | 57 | brbjtdknzf(jtceautltj) = avgcfuqber txufnlnmap (dzapmoknnq ) View more | Positive | 24 May 2024 | ||
(cervical cancer) | brbjtdknzf(jtceautltj) = ypnvvztswh txufnlnmap (dzapmoknnq ) View more | ||||||
Phase 1 | 16 | clotkruddi(tgsarklgzf) = fqqbculbej pegkuikjec (amwiroyihq ) View more | Positive | 26 May 2023 |
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Biosimilar
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Regulation
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