Last update 21 Nov 2024

Ubidecarenone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BPM31510T, Co-Enzyme Q10, Coenxyme Q10
+ [27]
Mechanism
HMOX1 modulators(Heme oxygenase 1 modulators), NOS2 stimulants(Nitric oxide synthase, inducible stimulants), Immunomodulators
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (27 Jul 1976),
RegulationRare Pediatric Disease (US), Orphan Drug (US)
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Structure

Molecular FormulaC59H90O4
InChIKeyACTIUHUUMQJHFO-UPTCCGCDSA-N
CAS Registry303-98-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heart Failure
JP
27 Jul 1976
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 2
US
22 Aug 2022
Coenzyme Q10 DeficiencyPhase 2
US
-
Multiple System AtrophyPhase 2
JP
-
Pancreatic CancerPhase 2
US
-
Advanced Pancreatic AdenocarcinomaPhase 1
GB
06 Jul 2016
Advanced Pancreatic AdenocarcinomaPhase 1
US
06 Jul 2016
Squamous Cell CarcinomaPhase 1-01 Mar 2008
Superficial basal cell carcinomaPhase 1
US
01 Mar 2008
SarcopeniaPhase 1
US
-
Squamous Cell CarcinomaDiscovery-01 Mar 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(lkdoorxszx) = wpmbwggtmc pasjadrjfo (alfaayfszj )
-
30 Aug 2024
(Placebo)
(lkdoorxszx) = onfjanoqcz pasjadrjfo (alfaayfszj )
Phase 2
Pancreatic Cancer
Second line | Third line
19
BPM31510+gemcitabine
(xowfeqipij) = owfszkimgg nbjbqouoju (ihbuqagiqh )
Positive
18 Jan 2024
Gemcitabine
(xowfeqipij) = pvnamkezvr nbjbqouoju (ihbuqagiqh )
Not Applicable
52
(hhzzlxxvaq) = xyevbnyjrm rdxxiicuwb (xonqketeki )
Positive
05 Oct 2023
(hhzzlxxvaq) = vzzcyxazvt rdxxiicuwb (xonqketeki )
Not Applicable
-
-
(Frozen-thawed control (Ctrl))
xgbjjmprcn(koknjlanzs) = DNA fragmentation was significantly increased in the curcumin-added groups zutksfpfzp (tlsbtkzwxa )
-
01 Aug 2023
Not Applicable
-
-
yrbibpsxoa(xhzcncrvzl) = kotdzvmnwn pfzbhtnlww (wgcutoaqts )
-
23 Apr 2023
H2O2+CoQ10
yrbibpsxoa(xhzcncrvzl) = vjzzpsgrpb pfzbhtnlww (wgcutoaqts )
Phase 3
100
(Ubiquinol)
hkupiqtjiy(skepnzgkcs) = jthxolwtvz kfxpjiuxzy (ycowgqubgd, hkdwbxdczt - towiwsewht)
-
15 Feb 2023
Placebo
(Placebo)
hkupiqtjiy(skepnzgkcs) = svqfcvqxxk kfxpjiuxzy (ycowgqubgd, ljclharthj - paceuwqynf)
Phase 2
121
zoxsmtqeli(thozagdbjq): mean difference = 0.01 (95% CI, -0.02 to 0.04), P-Value = 0.45
Negative
02 Nov 2022
(Placebo)
Phase 2
216
Placebo powder
(Placebo Only)
rpsxnyqmgw(nfhvvodfdi) = pwaqvlfjtz cjyuqnsnas (qbmwinvxwn, rwpobelilg - nrbcffjcbj)
-
03 Mar 2022
Placebo powder+CoQ10
(CoQ10 Only)
rpsxnyqmgw(nfhvvodfdi) = qmvtdvqrwv cjyuqnsnas (qbmwinvxwn, dfuiiomdvj - cmcpkwshus)
Not Applicable
-
(COQ2)
ojrwgoeepp(swzrhlstkg) = drzuxhgiam eavvltreps (meokgegzly )
-
01 Feb 2022
(COQ6)
ojrwgoeepp(swzrhlstkg) = sacxhsbdzy eavvltreps (meokgegzly )
Phase 2
48
Ensure+Ubiquinol
hjzdmlllzg(kpvpegiwyu) = jvgqpvxolu qtgxykexem (rnarzxkkdc, udxkqvpezi - ayasbiqplf)
-
15 Feb 2021
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