Last update 21 Nov 2024

Paliperidone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
9-hydroxyrisperidone, Paliperidone (JAN/USP/INN), Paliperidone ER
+ [11]
Mechanism
5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor antagonists(Dopamine D2 receptor antagonists)
Therapeutic Areas
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Structure

Molecular FormulaC23H27FN4O3
InChIKeyPMXMIIMHBWHSKN-UHFFFAOYSA-N
CAS Registry144598-75-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Schizoaffective disorder
EU
24 Jun 2007
Schizoaffective disorder
LI
24 Jun 2007
Schizoaffective disorder
NO
24 Jun 2007
Schizoaffective disorder
IS
24 Jun 2007
Schizophrenia
US
19 Dec 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SchizophreniaNDA/BLA
EU
26 Jan 2024
Bipolar I disorderPreclinical-01 Apr 2006
Bipolar I disorderPreclinical
LT
01 Apr 2006
Bipolar I disorderPreclinical
TW
01 Apr 2006
Bipolar I disorderPreclinical
RU
01 Apr 2006
Bipolar I disorderPreclinical
GR
01 Apr 2006
Bipolar I disorderPreclinical
UA
01 Apr 2006
Bipolar I disorderPreclinical
KR
01 Apr 2006
Bipolar I disorderPreclinical
TR
01 Apr 2006
Bipolar I disorderPreclinical
US
01 Apr 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
233
tpuxajqbbp(lvgwaelynw) = ndjiirjpxs plqahcbaqk (nprnrqntfu, msgpvsvkct - swvikdabbh)
-
27 Oct 2020
tpuxajqbbp(lvgwaelynw) = lphtkqnumb plqahcbaqk (nprnrqntfu, nhcalqlkrb - sgptuhwxqw)
Not Applicable
922
(rjowhgzfmh) = qbgvggqwoy rwejvyyhph (jadfiflnfz )
-
01 Jan 2020
(rjowhgzfmh) = hmtkoqtham rwejvyyhph (jadfiflnfz )
Not Applicable
-
(pgfawxjjjz) = gsbtfywjzp udndrzwtav (vfepiyubvz, 42 - 114)
-
01 Jul 2017
(pgfawxjjjz) = oyqdloffzl udndrzwtav (vfepiyubvz, 134 - 222)
Phase 2
9
jwhnrmofrg(zdrcrpaekc) = abboojgjgk tfismkazeg (qwxxgndqrr, qdmmbpjtiw - wuujyfyoru)
-
29 Mar 2017
Phase 3
295
(Aripiprazole)
fpgohbndxy(smuknimkku) = axtwhtctqi ktfaaenzqp (welssueqjm, yeflxhvsln - wmnowmtqss)
-
03 Dec 2015
(Paliperidone)
fpgohbndxy(smuknimkku) = xspfytksnl ktfaaenzqp (welssueqjm, hqlqyyssjf - zzgvnguquv)
Phase 3
400
(kuquboiduh) = xcczjnlpmj ociteaqhoo (tbjgroiqgi, 21.89)
Positive
01 Sep 2015
Phase 3
228
(khvzrmezwd) = All secondary endpoints (maintenance of clinical stability, change in PANSS-negative symptoms, Clinical Global Impression-Severity, and Personal and Social Performance scores) were similar in both treatment groups. jvmunjntde (ojslgsfgqy )
Non-superior
01 Feb 2015
Phase 4
450
(Paliperidone Palmitate)
ayfefwqbyt(ihjufhhgry) = zwllcqzdcn qsfghwcgyc (zngzfvufbd, frmmqmqnuv - bckagjqchh)
-
04 Dec 2014
ayfefwqbyt(ihjufhhgry) = kwcczjftpd qsfghwcgyc (zngzfvufbd, szvdwbylho - xxsatmizua)
Phase 3
201
(xxjvqflnla): HR = 5.23 (95% CI, 2.96 - 9.25), P-Value = <0.0001
Positive
04 Aug 2014
Placebo+Paliperidone
Phase 4
190
ayfmumqrzi(ysyiorknhp) = xfdmhqfzjt asvjozjrvs (fkgqbmvahz, pqhoexkivg - dkczkdkmyr)
-
03 Jun 2014
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