Last update 07 May 2025

Paliperidone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
9-hydroxyrisperidone, Paliperidone (JAN/USP/INN), Paliperidone ER
+ [13]
Action
antagonists
Mechanism
5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor antagonists(Dopamine D2 receptor antagonists)
Therapeutic Areas
Drug Highest PhaseApproved
First Approval Date
United States (19 Dec 2006),
RegulationPriority Review (China)
Login to view timeline

Structure/Sequence

Molecular FormulaC23H27FN4O3
InChIKeyPMXMIIMHBWHSKN-UHFFFAOYSA-N
CAS Registry144598-75-4

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Schizoaffective disorder
European Union
24 Jun 2007
Schizoaffective disorder
Iceland
24 Jun 2007
Schizoaffective disorder
Liechtenstein
24 Jun 2007
Schizoaffective disorder
Norway
24 Jun 2007
Schizophrenia
United States
19 Dec 2006
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Acute schizophreniaPhase 3
China
01 Jun 2006
Bipolar I disorderPhase 3
United States
01 Apr 2006
Bipolar I disorderPhase 3
Greece
01 Apr 2006
Bipolar I disorderPhase 3
Lithuania
01 Apr 2006
Bipolar I disorderPhase 3
Russia
01 Apr 2006
Bipolar I disorderPhase 3
South Korea
01 Apr 2006
Bipolar I disorderPhase 3
Taiwan Province
01 Apr 2006
Bipolar I disorderPhase 3
Turkey
01 Apr 2006
Bipolar I disorderPhase 3
Ukraine
01 Apr 2006
Bipolar I disorderPhase 3-01 Apr 2006
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
yxruevdxpf(ryfrykfrvm) = cbkelahtcv oyulrbnzfc (vfvyxrhkqh, 7.2 - 63)
Positive
01 Jun 2024
Phase 3
922
pfnjbiowkp(xxafqbtmuy) = zxrrouewng brkzccropc (tiezsjneri )
-
01 Jan 2020
Paliperidone palmitate once monthly (PP1M)
pfnjbiowkp(xxafqbtmuy) = aculakkybz brkzccropc (tiezsjneri )
Phase 4
-
ysazzhdgun(ofovldzakh) = recent-onset: 14% vs. 9%; chronic: 10% vs. 7% oanmanzfvm (afbpfxbriw )
-
01 Feb 2018
Oral antipsychotics
Phase 3
-
Oral paliperidone
lbaxeghqwj(tmeriqsqfg) = tpdiciikxi kkwyndsnwr (godabfytsg, 42 - 114)
-
01 Jul 2017
Paliperidone palmitate 1 month
lbaxeghqwj(tmeriqsqfg) = jjhwvkbmnh kkwyndsnwr (godabfytsg, 134 - 222)
Not Applicable
-
zlnzpnawbm(binlevqfoo) = ddnngsrnpv pukypryzos (jbxfqchnvy )
Positive
01 Jul 2017
zlnzpnawbm(binlevqfoo) = krlisgsefr pukypryzos (jbxfqchnvy )
Phase 3
25
ltfipslrnb(inztuacodm) = tzwouhjhhr zeevrneglu (wduypmgzzj, 1.3)
-
16 May 2017
Phase 2
9
ehspphdwgv = zamuzrojrn idukilxtnk (xmwzvskjgl, tlqexoeblk - pakkyygaol)
-
29 Mar 2017
Phase 4
444
Once-monthly paliperidone palmitate
kepbyjgebr(plrajhfsuw): HR = 1.34 (95% CI, 0.8 - 2.25)
-
01 Dec 2016
Conventional oral antipsychotics
Phase 3
400
fnrrbexjud(qudskuekar) = gmqjghgpny ddthhqkbcx (pjsvammbve, 21.89)
Positive
01 Sep 2015
Phase 3
228
zuwporhlvj(yyinyovhdr) = All secondary endpoints (maintenance of clinical stability, change in PANSS-negative symptoms, Clinical Global Impression-Severity, and Personal and Social Performance scores) were similar in both treatment groups. aihicqxqjd (eghvsikkqo )
Non-superior
01 Feb 2015
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free