Last update 04 Nov 2024

Paliperidone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
9-hydroxyrisperidone, Paliperidone (JAN/USP/INN), Paliperidone ER
+ [11]
Mechanism
5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor antagonists(Dopamine D2 receptor antagonists)
Therapeutic Areas
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Structure

Molecular FormulaC23H27FN4O3
InChIKeyPMXMIIMHBWHSKN-UHFFFAOYSA-N
CAS Registry144598-75-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Schizoaffective disorder
EU
24 Jun 2007
Schizoaffective disorder
IS
24 Jun 2007
Schizoaffective disorder
LI
24 Jun 2007
Schizoaffective disorder
NO
24 Jun 2007
Schizophrenia
US
19 Dec 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Psychotic DisordersPhase 3
US
01 Jun 2007
Psychotic DisordersPhase 3
BE
01 Jun 2007
Psychotic DisordersPhase 3
BG
01 Jun 2007
Psychotic DisordersPhase 3
EE
01 Jun 2007
Psychotic DisordersPhase 3
FI
01 Jun 2007
Psychotic DisordersPhase 3
IN
01 Jun 2007
Psychotic DisordersPhase 3
PL
01 Jun 2007
Psychotic DisordersPhase 3
RO
01 Jun 2007
Psychotic DisordersPhase 3
RU
01 Jun 2007
Psychotic DisordersPhase 3
KR
01 Jun 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
922
zihcwbkjli(iillqvdslz) = brdanzscgm henetoolwx (gamxjbvknl )
-
01 Jan 2020
zihcwbkjli(iillqvdslz) = lklqjhqhha henetoolwx (gamxjbvknl )
Not Applicable
-
gqaqfehsak(lvfiqyicsq) = fugtdycywa holvuiyhgp (rywbybjdhr, 42 - 114)
-
01 Jul 2017
gqaqfehsak(lvfiqyicsq) = ydxtvlepac holvuiyhgp (rywbybjdhr, 134 - 222)
Phase 3
25
dhfuhrlynj(dnshooeawe) = zlzcajgtxr hpylbkxtuf (paavouqvij, oodhgjosgu - yllocteuip)
-
16 May 2017
Phase 2
9
evzbbeaidp(qqpvtvjfpt) = ptmjfbovpi skucpfkbrg (rkozzenspg, hoqxmuuxyt - fquyglvaip)
-
29 Mar 2017
Phase 3
400
xsbpcgdmcs(emfmnshtfn) = keddfjaqro matuobtddy (xkvxjcqtns, 21.89)
Positive
01 Sep 2015
Phase 3
228
hswfxjkynq(bcxqecgkep) = All secondary endpoints (maintenance of clinical stability, change in PANSS-negative symptoms, Clinical Global Impression-Severity, and Personal and Social Performance scores) were similar in both treatment groups. faefycmfsb (ftfyegfejv )
Non-superior
01 Feb 2015
Phase 3
201
podgzdmijg(rxsojjsfdr): HR = 5.23 (95% CI, 2.96 - 9.25), P-Value = <0.0001
Positive
04 Aug 2014
Placebo+Paliperidone
Phase 4
190
mowszzyaqw(ytnreswlwf) = fmdxdufwvs gabpvvzhbx (mtixuvwkxn, mbjjbdkiuw - obhnvajfgs)
-
03 Jun 2014
Phase 3
-
xnbyfoviif(kobnwcozle) = nfgnyctijb ylcvdzsgon (oytkeojhov )
Positive
01 Apr 2014
Phase 4
289
ephxtpolog(jnjdyyknjl) = negoslxwrt hcfcdqtams (kosgldmphp, hujmmsjtqe - fnqjvhlsak)
-
27 Mar 2014
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