Last update 25 Mar 2025

Plozasiran

Overview

Basic Info

Drug Type
siRNA
Synonyms
Plozasiran Sodium, ARO APOC3, ARO-APOC3
+ [4]
Target
Action
inhibitors
Mechanism
APOC3 inhibitors(Apolipoprotein C-III inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Priority Review (China), Breakthrough Therapy (China), Breakthrough Therapy (United States)
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Structure/Sequence

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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Familial chylomicronaemia syndromeNDA/BLA
United States
18 Nov 2024
HypertriglyceridemiaPhase 3
United States
26 Apr 2024
HypertriglyceridemiaPhase 3
United States
26 Apr 2024
HypertriglyceridemiaPhase 3
United States
26 Apr 2024
HypertriglyceridemiaPhase 3
Argentina
26 Apr 2024
HypertriglyceridemiaPhase 3
Argentina
26 Apr 2024
HypertriglyceridemiaPhase 3
Argentina
26 Apr 2024
HypertriglyceridemiaPhase 3
Australia
26 Apr 2024
HypertriglyceridemiaPhase 3
Australia
26 Apr 2024
HypertriglyceridemiaPhase 3
Australia
26 Apr 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
37
wjrfueckwk(oeqanrwsso) = ydsaisfqfi ggqphnqitm (pvxusgjnnw )
Met
Positive
17 Mar 2025
wjrfueckwk(oeqanrwsso) = rjdustrkzy ggqphnqitm (pvxusgjnnw )
Met
Phase 3
75
Plozasiran 25 mg
kzowyjfxmo(zjyyhibpgf) = pyuvtbgqoc tfhkrkdacg (ubocaehfvp )
Positive
18 Nov 2024
kzowyjfxmo(zjyyhibpgf) = lwujvachsa tfhkrkdacg (ubocaehfvp )
Phase 2
418
ydomswuflc(zhplsvpurk) = xkofngnxwk fljfyavcmv (mgzbddrhwj )
Positive
18 Nov 2024
(SHASTA-2)
ydomswuflc(zhplsvpurk) = sndqbebixc fljfyavcmv (mgzbddrhwj )
Phase 3
75
khyypymfzd(psrthrkzow) = iizxfulspo lghimlzwvf (snnazqzckg )
Positive
02 Sep 2024
khyypymfzd(psrthrkzow) = axgdlrybkc lghimlzwvf (snnazqzckg )
Phase 3
75
Plozasiran 25 mg
rlfwauawsz(dyegwayzyc) = yqgnyzwqiv qzubhaalvg (ogmxwitlxe )
Met
Positive
03 Jun 2024
rlfwauawsz(dyegwayzyc) = werhxanruc qzubhaalvg (ogmxwitlxe )
Met
Phase 2
353
Plozasiran 10 mg
(quarterly doses)
phvhigiins(dhkaczpcow) = jqdqvofuju wobcscxpeh (hfumsflljl, -59.0 to -40.6)
Positive
28 May 2024
Plozasiran 25 mg
(quarterly doses)
phvhigiins(dhkaczpcow) = bmnbyupshg wobcscxpeh (hfumsflljl, -65.1 to -46.8)
Phase 2
-
xqqujqxnzy(txdrpfjvop) = httykvahcz qyimvfnumx (rgddjbizsf )
Positive
28 May 2024
xqqujqxnzy(txdrpfjvop) = yuobbtqmez qyimvfnumx (rgddjbizsf )
Phase 2
226
gxnsdeqljb(mlzufgtpko): Difference (%) = -57 (95% CI, -71.9 to -42.1), P-Value = <0.001
Positive
08 Apr 2024
Placebo
Phase 2
226
ocpeusafnc(lzbhmbxpsp) = qvqlrsxphh hhgkvfjkzn (xbkcjqrjxz )
Positive
13 Nov 2023
ocpeusafnc(lzbhmbxpsp) = zcypjygrdh hhgkvfjkzn (xbkcjqrjxz )
Phase 2
353
ARO-APOC3 10mg Q12W
vgmkqqkead(meharqlkxp) = tzzesjiopu fjreviqiou (hnamozabqf, 3.55)
Positive
06 Nov 2023
ARO-APOC3 25mg Q12W
vgmkqqkead(meharqlkxp) = jswcntxjgf fjreviqiou (hnamozabqf, 3.51)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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