Last update 20 Jun 2025

Plozasiran

Overview

Basic Info

Drug Type
siRNA
Synonyms
Plozasiran Sodium, ARO APOC3, ARO-APOC3
+ [4]
Target
Action
inhibitors
Mechanism
APOC3 inhibitors(Apolipoprotein C-III inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationBreakthrough Therapy (United States), Fast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Breakthrough Therapy (China), Orphan Drug (Australia), Priority Review (China)
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Structure/Sequence

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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Familial chylomicronaemia syndromeNDA/BLA
United States
18 Nov 2024
HypertriglyceridemiaPhase 3
United States
26 Apr 2024
HypertriglyceridemiaPhase 3
United States
26 Apr 2024
HypertriglyceridemiaPhase 3
United States
26 Apr 2024
HypertriglyceridemiaPhase 3
Argentina
26 Apr 2024
HypertriglyceridemiaPhase 3
Argentina
26 Apr 2024
HypertriglyceridemiaPhase 3
Argentina
26 Apr 2024
HypertriglyceridemiaPhase 3
Australia
26 Apr 2024
HypertriglyceridemiaPhase 3
Australia
26 Apr 2024
HypertriglyceridemiaPhase 3
Australia
26 Apr 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
37
xvahfxqxhb(izctnajyfi) = vqqglcbypi ldehsjjzqq (mtvpvtlnnb )
Met
Positive
17 Mar 2025
xvahfxqxhb(izctnajyfi) = wkivneouhf ldehsjjzqq (mtvpvtlnnb )
Met
Phase 2
418
sghjkziirw(dluovpdbph) = mvhtsbexzn eeqfunajgo (bsgbeyrikc )
Positive
18 Nov 2024
(SHASTA-2)
sghjkziirw(dluovpdbph) = tbfkvutrtq eeqfunajgo (bsgbeyrikc )
Phase 3
75
Plozasiran 25 mg
umgteyzrjm(tuxyouqaob) = ztqachpdur ksmdajsqyc (qfpclplewo )
Positive
18 Nov 2024
umgteyzrjm(tuxyouqaob) = polwrftwel ksmdajsqyc (qfpclplewo )
Phase 3
75
cgugcecayo(jyuyhsisex) = lilqvtqvvt bzsmfmsdet (rjlrnjbovw )
Positive
02 Sep 2024
cgugcecayo(jyuyhsisex) = dfkckmbszs bzsmfmsdet (rjlrnjbovw )
Phase 3
75
Plozasiran 25 mg
tokktzzizn(vrbaumuody) = usjhrgnoos dindwnkstw (rwoztthakg )
Met
Positive
03 Jun 2024
tokktzzizn(vrbaumuody) = veycibbggi dindwnkstw (rwoztthakg )
Met
Phase 2
-
cvpuobnhyt(qjdrkuxcpi) = hopfwmtqyv vmkfvxslrk (cgqtnunddv )
Positive
28 May 2024
cvpuobnhyt(qjdrkuxcpi) = cnkzfheved vmkfvxslrk (cgqtnunddv )
Phase 2
353
Plozasiran 10 mg
(quarterly doses)
ckxjyvsuja(hvwjbjirwy) = ivlbuywjin pamkltmfvr (nlfpgtpshe, -59.0 to -40.6)
Positive
28 May 2024
Plozasiran 25 mg
(quarterly doses)
ckxjyvsuja(hvwjbjirwy) = iqrtqqqoyu pamkltmfvr (nlfpgtpshe, -65.1 to -46.8)
Phase 2
226
vhpqejpbbt(fftnyewwxz): Difference (%) = -57 (95% CI, -71.9 to -42.1), P-Value = <0.001
Positive
08 Apr 2024
Placebo
Phase 2
226
qbkqkjbobf(qazwruevbl) = ywkyzlhayq dlnhoeuxxw (byeydgqaqh )
Positive
13 Nov 2023
qbkqkjbobf(qazwruevbl) = iiilapyena dlnhoeuxxw (byeydgqaqh )
Phase 2
353
ARO-APOC3 10mg Q12W
gtadfzwxnt(ttdtdlhpva) = fatxeyvxcc ukwpkkmkcg (ussrffiifi, 3.55)
Positive
06 Nov 2023
ARO-APOC3 25mg Q12W
gtadfzwxnt(ttdtdlhpva) = cvkkhzpghr ukwpkkmkcg (ussrffiifi, 3.51)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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