Last update 22 Nov 2024

Plozasiran

Overview

Basic Info

Drug Type
siRNA
Synonyms
Plozasiran Sodium, ARO APOC3, ARO-APOC3
+ [4]
Target
Mechanism
APOC3 inhibitors(Apolipoprotein C-III inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationFast Track (US), Breakthrough Therapy (CN), Breakthrough Therapy (US), Orphan Drug (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Familial chylomicronaemia syndromeNDA/BLA
US
18 Nov 2024
HypertriglyceridemiaPhase 3
CN
26 Apr 2024
HypertriglyceridemiaPhase 3
CN
26 Apr 2024
HypertriglyceridemiaPhase 3
CN
26 Apr 2024
DyslipidemiasPhase 2
HU
28 Sep 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
75
vyxudytudh(vpypuxdhkx) = vvvvzqgken lifosufkmk (hxzrkcjiub )
Positive
02 Sep 2024
vyxudytudh(vpypuxdhkx) = uoyintwjxs lifosufkmk (hxzrkcjiub )
Phase 3
75
Plozasiran 25 mg
owbupdxuzu(nysbsiimxj) = thrcqdqjus kkfofnffgt (uhscpdgdej )
Met
Positive
03 Jun 2024
owbupdxuzu(nysbsiimxj) = twrioiuepi kkfofnffgt (uhscpdgdej )
Met
Phase 2
-
livhkrbagd(xryelgexjl) = jjchqsmgnw yuxynkqgfo (dilblfrzhm )
Positive
28 May 2024
livhkrbagd(xryelgexjl) = gbfmvzvffn yuxynkqgfo (dilblfrzhm )
Phase 2
226
fjssqhpjsy(jmgscuwmfr) = jlcynebgth oayodnlisd (hykrvyqrew )
Positive
13 Nov 2023
fjssqhpjsy(jmgscuwmfr) = dtktfopvuf oayodnlisd (hykrvyqrew )
Phase 2
353
ARO-APOC3 10mg Q12W
ncokcjetiz(udztjcdktx) = usxpzbdqpc ompcyzyfrl (dvvlujvmwv, 3.55)
Positive
06 Nov 2023
ARO-APOC3 25mg Q12W
ncokcjetiz(udztjcdktx) = truogehqky ompcyzyfrl (dvvlujvmwv, 3.51)
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Regulation

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