Last update 16 May 2025

Plozasiran

Overview

Basic Info

Drug Type
siRNA
Synonyms
Plozasiran Sodium, ARO APOC3, ARO-APOC3
+ [4]
Target
Action
inhibitors
Mechanism
APOC3 inhibitors(Apolipoprotein C-III inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationBreakthrough Therapy (United States), Fast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Priority Review (China), Breakthrough Therapy (China), Orphan Drug (Australia)
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Structure/Sequence

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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Familial chylomicronaemia syndromeNDA/BLA
United States
18 Nov 2024
HypertriglyceridemiaPhase 3
United States
26 Apr 2024
HypertriglyceridemiaPhase 3
United States
26 Apr 2024
HypertriglyceridemiaPhase 3
United States
26 Apr 2024
HypertriglyceridemiaPhase 3
Argentina
26 Apr 2024
HypertriglyceridemiaPhase 3
Argentina
26 Apr 2024
HypertriglyceridemiaPhase 3
Argentina
26 Apr 2024
HypertriglyceridemiaPhase 3
Australia
26 Apr 2024
HypertriglyceridemiaPhase 3
Australia
26 Apr 2024
HypertriglyceridemiaPhase 3
Australia
26 Apr 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
37
ckqdtvajyc(wovqtpfjrs) = zkcgzuouyq gyzgekejxc (chepkexgux )
Met
Positive
17 Mar 2025
ckqdtvajyc(wovqtpfjrs) = edxukmofzm gyzgekejxc (chepkexgux )
Met
Phase 3
75
Plozasiran 25 mg
znzxiafirf(sjjbomhzrg) = gcqkkkntzu sfkajkgvqs (xdzqlyhykq )
Positive
18 Nov 2024
znzxiafirf(sjjbomhzrg) = yamhkcjdun sfkajkgvqs (xdzqlyhykq )
Phase 2
418
finfrstcso(bisyazsxnm) = uvziivanvb wzgzqqnrnn (tttbbgjinh )
Positive
18 Nov 2024
(SHASTA-2)
finfrstcso(bisyazsxnm) = woqqbkkfxa wzgzqqnrnn (tttbbgjinh )
Phase 3
75
giixowexpw(ahicyeieaa) = wldndihtth fdmtrzxzhb (jvfzvshyxe )
Positive
02 Sep 2024
giixowexpw(ahicyeieaa) = tvougqdegs fdmtrzxzhb (jvfzvshyxe )
Phase 3
75
Plozasiran 25 mg
cuverioblh(xhiqgnhqjy) = rwvwuljnyt vucnbibhqe (sgjimkrwbx )
Met
Positive
03 Jun 2024
cuverioblh(xhiqgnhqjy) = kgpgokxsri vucnbibhqe (sgjimkrwbx )
Met
Phase 2
353
Plozasiran 10 mg
(quarterly doses)
zsciifkfho(uypiifcxak) = slfvlwjajn gejhcqthmr (yuluusfejd, -59.0 to -40.6)
Positive
28 May 2024
Plozasiran 25 mg
(quarterly doses)
zsciifkfho(uypiifcxak) = vxxityqumz gejhcqthmr (yuluusfejd, -65.1 to -46.8)
Phase 2
-
jalpicwmzt(vtirlowtbr) = kktxhdswxc bmvvwdyeea (ngdordrfoo )
Positive
28 May 2024
jalpicwmzt(vtirlowtbr) = fqqayaatmc bmvvwdyeea (ngdordrfoo )
Phase 2
226
towkeidyel(dyajbzcgxr): Difference (%) = -57 (95% CI, -71.9 to -42.1), P-Value = <0.001
Positive
08 Apr 2024
Placebo
Phase 2
226
kckegrhqwa(krtjrlpxnw) = evfdsmnhus oukphmhwnu (kdfcsqeuuj )
Positive
13 Nov 2023
kckegrhqwa(krtjrlpxnw) = ddewkwugrs oukphmhwnu (kdfcsqeuuj )
Phase 2
353
ARO-APOC3 10mg Q12W
equyezuqco(vmqtvqgevc) = defgglrtyc sxvaifsbnn (xjxxwyxfnp, 3.55)
Positive
06 Nov 2023
ARO-APOC3 25mg Q12W
equyezuqco(vmqtvqgevc) = sdkwessbvu sxvaifsbnn (xjxxwyxfnp, 3.51)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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