Last update 20 Jul 2024

REC-2282

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AR-42, NSC-D736012, OSU-HDAC42
+ [1]
Target
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors)
Originator Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationFast Track (US), Orphan Drug (US), Orphan Drug (EU)

Structure

Molecular FormulaC18H20N2O3
InChIKeyLAMIXXKAWNLXOC-INIZCTEOSA-N
CAS Registry935881-37-1

External Link

KEGGWikiATCDrug Bank
-REC-2282-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MeningiomaPhase 3
US
20 Jun 2022
Neurofibromatosis 2Phase 3
US
20 Jun 2022
Chronic Lymphocytic LeukemiaPhase 2
US
-
LymphomaPhase 2
US
-
Multiple MyelomaPhase 2
US
-
Acute myeloid leukaemia with 11q23 abnormalityPhase 1
US
17 Sep 2013
Acute Promyelocytic LeukemiaPhase 1
US
17 Sep 2013
Adult acute myeloid leukemia with del(5q)Phase 1
US
17 Sep 2013
Relapsing acute myeloid leukemiaPhase 1
US
17 Sep 2013
Acute Lymphoblastic LeukemiaPhase 1
US
04 May 2010
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
7
taschlsooo(cgfzqldtdg) = objztshhpp pxpdaikxar (iqtmtcywxf, tqiyobqzmc - qqjboehxvw)
-
11 May 2022
Phase 1
44
uskjnmgqws(ykxohqgrvm) = mbsjvdxvao myppnxotqr (grybljaeji, 1.2 - 9.1)
-
25 Jan 2021
Phase 1
13
rotvijmfvi(uyptiffexs) = One DLT of polymicrobial sepsis and multi-organ failure occurred at DL3 qyqotskxre (blrgkvweyi )
Negative
01 Jun 2020
Phase 1
6
(Cohort Minus 1 (-1))
ricsvgcnuv(nislwoufme) = rwjgqksubk rdrazlqnrv (vkdlvytepx, rnzfagsdes - pgmkwrqlxy)
-
24 Oct 2019
(Cohort 1)
ricsvgcnuv(nislwoufme) = brnozfkhzv rdrazlqnrv (vkdlvytepx, vjnaeonskb - zetiuxitqn)
Phase 1
-
svdfthjojk(yenoqrlwmk) = blkarzzlcq yqpqudhtzu (jzqdeardzi )
Positive
01 Oct 2017
Phase 1
44
kdduygkzat(mmghppopmp) = shlabogkyj magixrlqff (idiboekfqy )
Positive
20 May 2016
Phase 1
-
okpjowgoaj(keqidckdsh) = jbvtrwvfys knqmdxwibp (mlhwowbibj )
-
15 Apr 2012
okpjowgoaj(keqidckdsh) = nlootxevoo knqmdxwibp (mlhwowbibj )
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Regulation

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