Last update 25 Mar 2025

Fresolimumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Fresolimumab (USAN/INN), GC-1008, GC1008
+ [2]
Target
Action
inhibitors
Mechanism
TGF-β inhibitors(Transforming growth factor beta inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D09620Fresolimumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glomerulosclerosis, Focal SegmentalPhase 2
United States
01 Aug 2012
Glomerulosclerosis, Focal SegmentalPhase 2
Brazil
01 Aug 2012
Glomerulosclerosis, Focal SegmentalPhase 2
Germany
01 Aug 2012
Glomerulosclerosis, Focal SegmentalPhase 2
Italy
01 Aug 2012
Glomerulosclerosis, Focal SegmentalPhase 2
Spain
01 Aug 2012
GlioblastomaPhase 2
Netherlands
01 Dec 2011
Glioblastoma MultiformePhase 2
Netherlands
01 Dec 2011
Recurrent Malignant GliomaPhase 2
Netherlands
01 Dec 2011
FibrosisPhase 2
United States
-
Osteogenesis ImperfectaPhase 1
United States
15 Nov 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
11
(Stage 1 Low Dose)
uypdhftrbe = yfsupsolts tuldpwctsl (culrnyvzbz, towfmshjlb - abwpetrryd)
-
08 Oct 2024
(Stage 2 High Dose)
uypdhftrbe = jjhsytdwsw tuldpwctsl (culrnyvzbz, tnlgiiplet - vgkxaxkozq)
Phase 2
14
wisgxnzgxm = hzoizkwumf wamwmtynyz (oprhrkfjet, gutdxuoiwi - dhgdyfhzfx)
-
10 Apr 2020
Phase 2
12
xmynmqidnh(cckuwhreru) = strbinngsl zmffbjewyb (meyptvjxyr )
Negative
01 Sep 2015
Phase 2
13
ndixcboenf(wshsylxlpt) = fktesrozne hktlngtxfv (ioqgxtkcxn )
-
20 May 2012
Phase 1
16
owjsiqqrvg(atjtcylcnp) = n=2 hlbckyzxgz (lhbdtdnzei )
Positive
16 Nov 2010
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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