Cambridge Antibody Technology

DUBLIN, Dec. 14, 2023 /PRNewswire/ -- The "Adalimumab (Humira) Biosimilars Pipeline Review" report has been added to ResearchAndMarkets.com's offering. This product provides basic information on approved drugs and drug candidates in research and development as biosimilar antibodies of Humira (adalimumab). Adalimumab (drug code: LU-200134) was discovered by Knoll Pharmaceuticals, a subsidiary of BASF, using phage display technology from Cambridge Antibody Technology (CAT, acquired by AstraZeneca). In 2001, Abbott acquired Knoll Pharmaceuticals for US$ 6.9 bln, and continued clinical development of adalimumab (drug code: ABT-D2E7) until first approval in 2022 and subsequent approvals in various indications and for different formulations and presentation forms. Since its launch in 2003 for rheumatoid arthritis, Humira annual sales exceeded $1 billion in 2005 for the first time, and exceeded $2 billion in annual sales in 2006. In January 2013, Abbott completed the separation of its research-based pharmaceuticals business, which became AbbVie, a new independent biopharmaceutical company. Humira generated cumulative worldwide (ex Japan) sales for Abbott/AbbVie of more than US$ 213 bln. Eisai holds commercialization rights for Humira in Japan. Adalimumab is a recombinant human IgG1 monoclonal antibody created using phage display technology resulting in an antibody with human derived heavy and light chain variable regions and human IgG1:k constant regions. Adalimumab is produced by recombinant DNA technology in a mammalian cell (Chinese Hamster Ovary (CHO)) expression system and is purified by a process that includes specific viral inactivation and removal steps. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons. Humira's main patents expired in 2016 and first biosimilar versions of Humira were launched in Europe in 2018. AbbVie filed about 250 patent applications for Humira in the U.S., 90% of them following the drug's 2002 approval. The strengthened patent shield has stretched AbbVie's legal monopoly in the U.S. for six years beyond the expiration of Humira's main patent in 2016. Amgen was the first to launch its Humira biosimilar in the US in January 2023, and more entries of Humira biosimilars into the US market are scheduled over the course of 2023, mainly in July. Biosimilars are follow-on versions of biopharmaceuticals, for which exclusivity has expired. They are approved via stringent regulatory pathways in highly regulated markets (such as EU, US, Japan, Canada, Australia) based on proven similarity of the biosimilar with the originator biopharmaceutical reference product. In the US, Humira is approved for treatment of Moderate to severe rheumatoid arthritis (RA) in adults; Moderate to severe polyarticular juvenile idiopathic arthritis (JIA) in children 2 years of age and older; Psoriatic arthritis (PsA) in adults; Ankylosing spondylitis (AS) in adults; Moderate to severe hidradenitis suppurativa (HS) in people 12 years and older; Moderate to severe Crohn's disease (CD) in adults and children 6 years of age and older; Moderate to severe ulcerative colitis (UC) in adults and children 5 years of age and older; Moderate to severe chronic plaque psoriasis (Ps) in adults; and Non-infectious intermediate, posterior, and panuveitis in adults and children 2 years of age and older. This product consists of: Competitors described in a tabular format covering drug code/INN, target(s)/MoA, class of compound, territory of main competitor, indication(s) & R&D stage, including published sales data. Project History with link to source of information (press release, homepage, abstracts, presentations, annual reports etc). One-month online access to the publisher's database for adalimumab biosimilars (prerequisite: access to internet). For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

SENISCA strengthens Board with the appointment of Dr. David Chiswell, Ph.D, OBE as Chairman Highly experienced biotech veteran to support SENISCA’s rapid development of its senotherapeutic platform Exeter, UK — 14 November 2023: SENISCA SENISCA, a biotechnology company developing RNA based therapeutics to reverse cellular senescence and treat age-related disease, today announces the appointment of Dr. David Chiswell Ph.D, OBE as Chairman of the Board. Dr. David Chiswell is one of the UK’s most successful biotechnology executives, with extensive experience in the development of early-stage biotechnology companies over 30 years in the industry. He joins the SENISCA Board having co-founded Cambridge Antibody Technology (CAT) in 1990 and served as its Chief Executive Officer (‘CEO’) from 1996 to 2002, taking CAT onto both the London Stock Exchange and Nasdaq. He also served as CEO of Nabriva Therapeutics from 2009 to 2012, following which he was appointed as CEO of Kymab Ltd. from 2015 to 2018. Dr. Chiswell currently serves as Chairman of Epsilogen Ltd. and is a director of Avillion Bond 2 Development 2 GP and the Schiehallion Fund (LSE:MNTN). Dr. Chiswell has served as the Chairman of the Board of various biotechnology companies including Albireo, Arrow and Sosei. He was also formerly Chairman of the UK BioIndustry Association, with his major contributions to the industry being recognized with the awarding of an OBE by HM the Queen in 2006. Dr. Sarah Cole, CEO of SENISCA, commented: “We are honoured to welcome Dr. Chiswell to our Board at SENISCA. His deep knowledge and expertise in the biotechnology sector – particularly in early-stage companies, combined with his strategic expertise will be crucial as we continue our evolution towards becoming a clinical stage biotechnology company developing novel senotherapeutics to treat age-related disease. Our ability to attract someone of David’s calibre speaks volumes about the quality of our science and the strong foundational work our team has undertaken.” Dr. David Chiswell, Chairman of the Board of SENISCA commented: “SENISCA is a revolutionary company with the potential to transform the landscape of senotherapeutic treatments. I am thrilled to be joining the Company as Chairman, and I look forward to collaborating with the Board and leadership team as SENISCA progresses into the next stage of its development.” - Ends - For more informationSarah ColeChief Executive Officer, SENISCAinfo@senisca.com For mediaICR ConsiliumChris Welsh, Evi Usehwelsh@consilium-comms.com About SENISCA SENISCA is an award-winning, RNA therapeutics spinout from the University of Exeter. The Company is focused on modulating RNA biology to treat age-related disease. Underpinned by more than 15 years of world-leading research, SENISCA has identified an officially recognized, novel and druggable component of the cellular ageing (senescence) response, which can be specifically targeted in the context of multiple pharmacological and skin health indications. The Company is developing a portfolio of proprietary senotherapeutics, that target cell senescence for cellular rejuvenation in the treatment of age-related disease. SENISCA’s senotherapeutics specifically target the novel cellular pathway which causes cell rejuvenation and positively impacts markers of disease modification in patient-derived models. In line with the rapid evolution of the company, R & D activities are focused on IND data generation. SENISCA’s platform technology has broad applicability for multiple age-related diseases including those of the eyes, lungs, joints, and brain. For many such diseases, current treatments are palliative rather than curative, with varying success rates. These diseases represent a high unmet medical need, are amenable to a local route of therapeutic administration and are driven by senescence. Targeting these specific diseases will streamline progress towards the clinic by avoiding potential pitfalls of systemic delivery. SENISCA’s novel senotherapeutics will be mined and commercialized through partnership or co-development models that will sit alongside internal programmes. If you would like to learn more about SENISCA, please contact Jennie Jepperson, Executive Assistant at SENISCA (Jennie.Jepperson@senisca.com).

Eva-Lotta Allan's excellent track record of corporate, business development and operational experience strengthens industry-leading Board and Executive Leadership team Maxion's lead KnotBody® programme is progressing rapidly towards preclinical development with a first-in-class and best-in-class potential CAMBRIDGE, England, Sept. 21, 2023 /PRNewswire/ -- Today, Maxion Therapeutics ("Maxion"), the biotechnology company developing antibody-based drugs for previously untreatable ion channel- and GPCR-driven diseases, announced the appointment of senior industry leader Eva-Lotta Allan as the Chair of its Board of Directors. The announcement comes at an important moment of growth by the company as it advances its lead programme towards the clinic, following its USD $16 million Series A fundraise earlier this year. Eva-Lotta brings significant Board Chair and Non-Executive Director (NED) experience from life science companies and 30 years of corporate, business development and operational expertise combined with a wealth of partnership experience from the biotech industry. As Immunocore's Chief Business Officer (CBO), Eva-Lotta achieved USD $320 million Series A fundraising and established significant partnerships with top pharmaceutical companies over five years. Prior to that, she was CBO at Ablynx for seven years, participating in taking the company public and completed several strategic partnerships. Eva-Lotta is currently Chair of Draupnir Bio, and is NED at Almirall (where she also chairs the Nomination and Remuneration Committee), Aleta BioTherapeutics, and Crescendo Biologics. Eva-Lotta Allan, Chair, Board of Directors, Maxion Therapeutics, commented: "I'm delighted to be appointed to Maxion at such an exciting time in its development. The company has established its KnotBody® technology and is now advancing its proprietary lead programme towards preclinical development. I believe that KnotBodies have tremendous potential to address the difficult area of targeting ion channels and GPCRs in disease areas with high unmet medical need, such as autoimmune conditions and chronic pain. I look forward to working with the Board of Directors and the rest of the Maxion team to help improve patients' lives while creating value for our shareholders." Dr John McCafferty, Chief Executive Officer (CEO), Maxion Therapeutics, stated: "Eva-Lotta is a highly experienced and respected leader with a hugely impressive track record in business development and corporate leadership. Her guidance and mentorship will be vital in helping the business strike the right balance between maintaining its innovative and pioneering spirit, while developing a robust strategy and frameworks for delivering innovative medicines into the market. I am thrilled that she is joining Maxion." Maxion was co-founded by CEO Dr John McCafferty and Chief Scientific Officer Dr Aneesh Karatt Vellatt, who together co-invented the KnotBody platform. Eva-Lotta joins Aneesh and John on the Board alongside Dr Sohaib Mir (Senior Investment Principal at LifeArc Ventures), Dr Tim Funnell (Partner at Monograph Capital), Lucy Edwardes Jones (Investor at BGF), and Non-Executive Director Dr Tom Weaver (CEO, PetMedix). Maxion is developing novel biologic medicines for ion channels and GPCRs, which are critical cell surface proteins involved in a wide range of untreated or poorly-treated diseases, including autoimmune conditions and chronic pain. Maxion is applying its patented KnotBody technology to generate potent, selective, and long-acting antibody-like drugs. KnotBody technology combines the benefits of naturally occurring mini-proteins, which have ion channel modulating activity, with antibodies, using state-of-the-art phage and mammalian display technologies. The resulting fusion protein, which combines the drug-like benefits of both molecules, helps address key challenges in ion channel and GPCR drug discovery. About Maxion Therapeutics Maxion Therapeutics is developing novel biologic medicines for ion channels and GPCRs, which are critical cell surface proteins involved in a wide range of untreated or poorly-treated diseases, including autoimmune conditions and chronic pain. Maxion is applying its patented KnotBody® technology to generate potent, selective, and long-acting antibody-like drugs. KnotBody technology combines the benefits of naturally occurring mini-proteins, which have ion channel modulating activity, with antibodies, using state-of-the-art phage and mammalian display technologies. The resulting fusion protein, which combines the drug-like benefits of both molecules, helps address key challenges in ion channel and GPCR drug discovery. Based at Unity Campus, near Cambridge, UK, Maxion Therapeutics is driven by an experienced team with an excellent track record. CEO and co-founder Dr John McCafferty (previously co-founder of Cambridge Antibody Technology and IONTAS) and CSO and co-founder Dr Aneesh Karatt Vellatt (also co-founder of IONTAS) co-invented KnotBody technology. Dr McCafferty previously co-invented antibody phage display, which was the subject of the 2018 Nobel Prize in Chemistry awarded to his co-inventor Sir Gregory Winter. The company is currently developing its KnotBody pipeline, including candidates with significant potential to be first-in-class and best-in-class therapeutics. For more information, visit Logo - SOURCE Maxion Therapeutics