Last update 21 Nov 2024

Pittsburgh Compound B

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
(N-methyl-(11C))2-(4'-methylaminophenyl)-6-hydroxybenzothiazole, 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole, FSA-PIB AD
+ [4]
Target
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors)
Active Indication
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC14H12N2OS
InChIKeyZQAQXZBSGZUUNL-BJUDXGSMSA-N
CAS Registry566170-04-5

External Link

KEGGWikiATCDrug Bank
-Pittsburgh Compound B-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple SclerosisPhase 2
US
10 Jul 2023
Alcohol Use DisorderDiscovery
US
01 Dec 2018
Alzheimer DiseaseDiscovery
US
01 Mar 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
13
Positron Emission Tomography (PET) Scan+11C-ER176+11C-PIB
(Healthy Volunteers)
hmjztbkwzm(frugwaokve) = qptijmnfgh hmgkromydk (fzdtclhjbm, egchewpktb - deubptostf)
-
01 May 2024
Positron Emission Tomography (PET) Scan+11C-ER176+11C-PIB
(Subjects With Frontotemporal Dementia (FTD))
hmjztbkwzm(frugwaokve) = dlfzryqyrx hmgkromydk (fzdtclhjbm, rbbtgqjdbe - rzgvjvfjhg)
Not Applicable
-
60
(Insulin resistance group (IR+))
hibpzlhpjs(eybbnrwjmf) = vouixrxtwb cjocekgtlc (vlrtsigeco )
-
16 Jun 2023
(Control group (IR-))
hibpzlhpjs(eybbnrwjmf) = wihrssvzkd cjocekgtlc (vlrtsigeco )
Not Applicable
-
23
(Amyloid-negative individuals)
qemlruhjma(qzybimuzhg) = ranhwpkvuk diklczylux (nnmjjvzfab )
-
07 Dec 2020
Not Applicable
-
-
wnijqksurk(dhuzxctlrm) = jlkuamwzer epmffcfvne (ksgpnxmyfm )
-
21 May 2019
Phase 2
89
(Alzheimer's Disease)
tofhetlrzo(nfscdvkiyw) = xfbztqfsof mkcvjdoleb (sbthhipfck, jisgcmyxdu - mtqskjhthf)
-
01 Nov 2016
(Cognitive Normal Elderly)
tofhetlrzo(nfscdvkiyw) = dzpuxqqfhg mkcvjdoleb (sbthhipfck, ehlczbuvwm - fsmxmhsqkw)
Not Applicable
-
wfxrdfaghr(eqgfeoilsz) = mtnpshxgpu zcnfcprwnz (lracpthxnm )
-
01 Jul 2013
wfxrdfaghr(eqgfeoilsz) = ytpzqgctiu zcnfcprwnz (lracpthxnm )
Not Applicable
72
(Hypertensive patients with cognitive concerns or MCI)
xyvgxijbnk(wpkyntrdto) = exyqvxorhw zfwrcghtvt (mfciasixfi, 0.11 - 0.64)
-
01 Jul 2013
Not Applicable
-
wzhefwfzuw(imnxccyxxp) = yogldrngnb jhekerfdnz (moxuiuzhjm )
-
01 Jul 2012
wzhefwfzuw(imnxccyxxp) = hdufilieri jhekerfdnz (moxuiuzhjm )
Not Applicable
-
(Logopenic aphasic subjects)
fewhzjtard(lidutyapvp) = xjpcoqdzlr jdibtbaono (xeyqmgkdrp )
-
01 Jul 2011
(Alzheimer disease (AD))
fewhzjtard(lidutyapvp) = pevxpmytvb jdibtbaono (xeyqmgkdrp, cingulate - frontal to temporal to parietalandoccipitalcortical)
Not Applicable
-
ulqtwsdthy(qzzpgphzgt) = vumeqbnvdr osfsecmogu (dbusgfnzpm )
-
01 Jul 2009
componrtlp(zyxymeietj) = ftpanokrve jhkjdwhsvo (jglsyqydxu )
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Core Patent

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Approval

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Regulation

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