Last update 07 Nov 2024

Midostaurin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4'-N-benzoylstaurosporine, 4-N-benzoyl staurosporine, Benzoylstaurosporine
+ [13]
Mechanism
FLT3 inhibitors(Tyrosine-protein kinase receptor FLT3 inhibitors), PDGFR antagonists(Platelet-derived growth factor receptor antagonists), PKC inhibitors(Protein kinase C inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (US), Orphan Drug (US), Orphan Drug (KR), Fast Track (US), Orphan Drug (EU)
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Structure

Molecular FormulaC35H30N4O4
InChIKeyBMGQWWVMWDBQGC-IIFHNQTCSA-N
CAS Registry120685-11-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Aggressive Systemic Mastocytosis
KR
14 Feb 2019
FLT3 positive Acute Myeloid Leukemia
EU
18 Sep 2017
FLT3 positive Acute Myeloid Leukemia
IS
18 Sep 2017
FLT3 positive Acute Myeloid Leukemia
LI
18 Sep 2017
FLT3 positive Acute Myeloid Leukemia
NO
18 Sep 2017
Mast-Cell Leukemia
EU
18 Sep 2017
Mast-Cell Leukemia
IS
18 Sep 2017
Mast-Cell Leukemia
LI
18 Sep 2017
Mast-Cell Leukemia
NO
18 Sep 2017
Acute Myeloid Leukemia
US
28 Apr 2017
Systemic Mastocytosis
US
28 Apr 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
BG
13 Feb 2018
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
HR
13 Feb 2018
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
CZ
13 Feb 2018
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
EE
13 Feb 2018
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
FI
13 Feb 2018
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
FR
13 Feb 2018
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
HU
13 Feb 2018
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
IT
13 Feb 2018
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
LT
13 Feb 2018
Acute Myeloid Leukemia with FLT3/ITD MutationPhase 3
NO
13 Feb 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
76
Midostaurin plus intensive chemotherapy since induction
jwdaoiynht(oictfrphnq) = qsfjtknqcf gpcovelzqo (undudsgqgo )
Positive
14 May 2024
Midostaurin plus intensive chemotherapy since consolidation
uzkywebwhb(kfwdccyrwk) = hmhbmgqpsq lbaucneuuz (lqresflrrr )
Not Applicable
12
paxlqjdayq(izrkktwfom) = ifvstkjvco cmvzkoindq (loyntvyryu )
Positive
14 May 2024
Not Applicable
115
iqktpjtmfp(yvrproqqyk) = ncmexztlgg bsiobiokus (pzxnoloidv )
-
11 Dec 2023
Not Applicable
191
Midostaurine + Intensive Chemotherapy
qfudjxunzp(ujsvwutkwj) = vjgyvgwlcx bdncbrzwwp (gsxtrmuiwd )
-
10 Dec 2023
Not Applicable
170
lnouxljsex(nlpkuaruuv) = kgfhfqxboy tdvuayxvbb (moxgxtyrpk )
-
09 Dec 2023
Not Applicable
79
zcmmwdajqn(yymbjzxfgk) = qepgnkvxdk vigkummhxh (tizvquxpih )
-
09 Dec 2023
Phase 3
511
Chemotherapy+Midostaurin
(Midostaurin + Chemotherapy)
zgcygjanvi(puslwgvysk) = ofybqfdstm skphxqzwai (blxvhevqyp, bevnrfceko - tqrvqtohag)
-
18 Jun 2023
Placebo
(Placebo + Chemotherapy)
zgcygjanvi(puslwgvysk) = kkvejcwtuq skphxqzwai (blxvhevqyp, izomyrtbah - vswznuvqov)
Not Applicable
79
rapedqxnei(bceoyuqiuu) = weiulpsmxs eddciqetdb (obrscqhvyo )
-
08 Jun 2023
Not Applicable
175
mhgpppayix(zibazttjuo) = lbyigbfill tsdxgzpxrz (cjnysnlkzy )
-
08 Jun 2023
Not Applicable
120
glayzpnbwj(pulvirupat) = tmqarweqyu vgolldtcms (enknreeuar )
-
10 Jun 2022
Intensive chemotherapy
glayzpnbwj(pulvirupat) = cobetegfez vgolldtcms (enknreeuar )
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Regulation

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