Delving into the Latest Updates on Poly-gamma-glutamic acid-containing vaccine(BL) with Synapse

Overview

Basic Info

Drug Type

Therapeutic vaccine

Synonyms

Poly-gamma-glutamic acid, poly-γ-glutamic acid

Target-

Mechanism

Immunostimulants, Natural killer cells stimulants(Natural killer cells stimulants)

Therapeutic Areas

NeoplasmsDigestive System Disorders

Active Indication

Colorectal Cancer

Inactive Indication

Uterine Cervical Dysplasia

Originator Organization

MOA Life Plus Co., Ltd.

Active Organization

MOA Life Plus Co., Ltd.

Inactive Organization

HK inno.N Corp.Tianjin Intl Joint Academy of Biotechnology & Medicine

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

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BACKGROUNDSignificant efforts have been devoted to assess the effects of the poly-gamma-glutamic acid (γ-PGA) on crop growth, yield and quality, soil water retention and fertilizer use efficiency. However, few studies have evaluated the effects of γ-PGA on greenhouse gas (GHG) emissions and grain yield from paddy fields with different rice varieties.METHODSIn the present study, a split-plot field experiment was performed to comprehensively evaluate the effects of γ-PGA concentrations (i.e., no application [P0] and 25.0 kg ha^-1 of γ-PGA fermentation solution [P1]) and rice varieties (i.e., conventional rice [Huanghuazhan, H], red rice [Gangteyou 8024, R] and black rice [Black indica rice, B]) on the grain yield, GHG emissions, global warming potential (GWP), greenhouse gas intensity (GHGI), net ecosystem economic profit (NEEP) and carbon footprint (CF) during 2022 and 2023 rice-growing seasons in central China.RESULTSApplication of γ-PGA significantly affected the GHGs emissions, NEEP and CF. Compared with P0 treatments, P1 treatments significantly increased the NEEP by 1.2-11.2 %, and decreased the GWP by 12.9-35.4 %, the GHGI by 16.5-35.9 % and the CF by 13.8-26.2 % in 2022-2023. Application of γ-PGA showed a tendency to increase the yield. Under γ-PGA application condition, R treatment exhibited the lowest GWP, GHGI and CF, and the highest yield and NEEP compared with B and H treatments.CONCLUSIONOur results suggest that γ-PGA application is an ecological agricultural management to increase rice yield, reduce greenhouse gas emission and increase economic benefit, and its advantage is more significant for red rice than for other rice varieties.

01 Sep 2024·Heliyon

Ameliorative effect of poly-γ-glutamic acid biopreparation on coastal saline soil

Article

Author: Liu, Pei ; Ali, Jawad ; Chang, Tingting ; Hamoud, Yousef Alhaj ; Zheng, Jinhai ; Shaghaleh, Hiba ; Chen, Lihua ; Huang, He

To investigate the effect of poly-γ-glutamic acid (γ-PGA) biopreparation on ameliorating coastal saline soil, three treatments were established: soil salt washed treatment (CK), soil salt washed with added γ-PGA (PGA), soil salt washed with added γ-PGA biopreparation (PGAB). This study determined the effects of γ-PGA on coastal saline soil by analyzing soil aggregate, soil evaporation, soil vertical water and salt distribution, and soil cation content, soil pH, soil nutrient content and soil microorganism quantity. Results showed that γ-PGA had an ameliorative effect on saline soil, with the PGAB treatment exhibiting the most pronounced ameliorative effect compared to CK. Adding PGAB reduced soil evaporation by 30.45 %, soil salt content by 27.91 %, meanwhile increasing plant height by 33.86 %, plant fresh weight by 98.54 %, soil aggregate diameter by 6.68 times, soil water content by 26.47 % (P < 0.05). Additionally, soil total nitrogen was increased by 50.0 % in PGAB treatment, and available nitrogen and phosphorus contents were increased by 1.68 times and 85.83 % (P < 0.05), respectively. Populations of soil-culturable bacteria and fungi of PGAB treatment increased by 65.96 % and 1.23 times, respectively (P < 0.05). After salt-washing process, adding PGAB improved soil physicochemical properties, which altered the ecological environment of rhizosphere soil and promoted plant growth. The results can provide a practical approach for ameliorating coastal saline soils.

30 Aug 2024·Journal of the Science of Food and Agriculture

Poly‐γ‐glutamic acid enhanced the yield and photosynthesis of soybeans by adjusting soil aggregates and water distribution

Article

Author: Wang, Ying ; Shi, Wenjuan ; Jing, Bo

AbstractBACKGROUNDPoly‐γ‐glutamic acid (γ‐PGA) is employed extensively in agriculture to enhance soil water retention; however, the underlying mechanism by which γ‐PGA improves soil structure and soybean productivity in arid regions remains poorly understood. A micro‐scale field experiment was conducted in the arid region of northwest China, employing five concentrations of γ‐PGA to investigate its impacts on soybean yield, photosynthesis, and water‐use efficiency, as well as soil aggregates and water distribution. The five levels of γ‐PGA were 0 (CK), 10 (P1), 20 (P2), 40 (P3), and 80 kg ha−1 (P4).RESULTSThe results demonstrated that the application of γ‐PGA significantly improved soybean yield, photosynthesis, and chlorophyll content. It resulted in a decrease in soil aggregate content with a maximum diameter of less than 0.053 mm and an increase in the stability of soil aggregates in the uppermost layer of the soil (0–30 cm). The application of γ‐PGA significantly increased soil water content, particularly in the uppermost layer of the soil, and effectively reduced water consumption and improving water use efficiency in soybeans. Overall, the P3 treatment exhibited the most pronounced improvement of soybean yield, photosynthesis, water‐use efficiency, as well as distribution of soil aggregates and water. The correlation matrix heatmap also revealed a strong correlation between improvement of soybean yield or photosynthesis at various γ‐PGA application levels and the enhancement of soil stability or soil water content.CONCLUSIONThe multivariate regression analysis revealed that an optimal application level of 46 kg ha−1γ‐PGA could enhance effectively both yield and water use efficiency of soybean in the arid region of northwest China. © 2024 Society of Chemical Industry.

100 Deals associated with Poly-gamma-glutamic acid-containing vaccine(BL)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Colorectal Cancer	Preclinical	KR	MOA Life Plus Co., Ltd.	22 Mar 2024
Uterine Cervical Dysplasia	Discovery	-	HK inno.N Corp.	-
Uterine Cervical Dysplasia	Discovery	CN	Tianjin Intl Joint Academy of Biotechnology & Medicine	-
Uterine Cervical Dysplasia	Discovery	KR	MOA Life Plus Co., Ltd.	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01826045 (Pubmed \| J Biol Chem)	Phase 2	Uterine Cervical Dysplasia	195	Poly-gamma-glutamic acid (γ-PGA)	(unrjcencaa) = autwfrzkkv akovapocsi (adqyrqiriy )	-	01 Jan 2019
				Placebo	(unrjcencaa) = celgsgrslz akovapocsi (adqyrqiriy )