Delving into the Latest Updates on Tianjin Intl Joint Academy of Biotechnology & Medicine with Synapse

Overview

Tags

Skin and Musculoskeletal Diseases

Neoplasms

Immune System Diseases

Nanobody

Recombinant polypeptide

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Immune System Diseases	2
Endocrinology and Metabolic Disease	1
Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1
Recombinant polypeptide	1
Nanobody	1

Top 5 Target	Count

30S subunit(30S ribosomal subunit)	1
BAFF-R(B-cell activating factor receptor)	1
αvβ3(Integrin alpha-V/beta-3)	1

主要目的：评价盐酸多西环素片治疗晚期恶性实体瘤患者的安全性和耐受性，并观察最大耐受剂量，确定Ⅱ期临床试验推荐剂量。次要目的：（1）评价盐酸多西环素片在晚期恶性实体瘤患者中的药代动力学特征。（2）按照实体瘤疗效评价标准（RECIST 1.1），通过客观缓解率和疾病控制率初步评价盐酸多西环素片的抗肿瘤疗效。

[Translation]

Primary objectives: To evaluate the safety and tolerability of doxycycline hydrochloride tablets in the treatment of patients with advanced malignant solid tumors, observe the maximum tolerated dose, and determine the recommended dose for phase II clinical trials. Secondary objectives: (1) To evaluate the pharmacokinetic characteristics of doxycycline hydrochloride tablets in patients with advanced malignant solid tumors. (2) To preliminarily evaluate the anti-tumor efficacy of doxycycline hydrochloride tablets by objective response rate and disease control rate according to the solid tumor efficacy evaluation criteria (RECIST 1.1).

Start Date-

Sponsor / Collaborator

Kaifeng Pharmaceutical (Group) Co., Ltd.

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100 Clinical Results associated with Tianjin Intl Joint Academy of Biotechnology & Medicine

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0 Patents (Medical) associated with Tianjin Intl Joint Academy of Biotechnology & Medicine

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100 Deals associated with Tianjin Intl Joint Academy of Biotechnology & Medicine

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100 Translational Medicine associated with Tianjin Intl Joint Academy of Biotechnology & Medicine

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

Phase 1 Clinical

Phase 2 Clinical

1

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

EGT-022 ( αvβ3 )	Pressure Ulcer More	Phase 2
Doxycycline ( 30S subunit )	Advanced Malignant Solid Neoplasm More	Phase 1
CN116987192 ( BAFF-R )	Immune System Diseases More	Discovery
Poly-gamma-glutamic acid-containing vaccine(BL)	Uterine Cervical Dysplasia More	Pending