Drug Type Small molecule drug |
Synonyms Sacubitril, Sacubitril (JAN/USAN/INN), AHU-377 |
Target |
Action inhibitors |
Mechanism enkephalinase inhibitors(Neprilysin inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC24H29NO5 |
InChIKeyPYNXFZCZUAOOQC-UTKZUKDTSA-N |
CAS Registry149709-62-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10225 | Sacubitril |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Heart Failure | Phase 3 | United States | 02 May 2019 | |
Heart Failure | Phase 3 | Japan | 02 May 2019 | |
Heart Failure | Phase 3 | Argentina | 02 May 2019 | |
Heart Failure | Phase 3 | Austria | 02 May 2019 | |
Heart Failure | Phase 3 | Bulgaria | 02 May 2019 | |
Heart Failure | Phase 3 | Canada | 02 May 2019 | |
Heart Failure | Phase 3 | Croatia | 02 May 2019 | |
Heart Failure | Phase 3 | Czechia | 02 May 2019 | |
Heart Failure | Phase 3 | Finland | 02 May 2019 | |
Heart Failure | Phase 3 | France | 02 May 2019 |
Phase 3 | 216 | valsartan+sacubitril (Age Group 1) | uxwxhnyfeo = ldbbbbzgre ngqsgoupue (xailvwqbeg, kwroqzdsms - qzomzdpmth) View more | - | 16 Jul 2024 | ||
valsartan+sacubitril (Age Group 2) | uxwxhnyfeo = uiuwdbqcud ngqsgoupue (xailvwqbeg, seeakuyplm - yafldacusj) View more | ||||||
Phase 3 | 1,197 | Sacubitril/allisartan 240 mg | tsvgixqhlg(buqjtmjdyj) = tcvlvbckbn rddierlbvi (wwvcsiincj, -4.2 to 0.4) | Positive | 01 May 2024 | ||
Sacubitril/allisartan 480 mg | tsvgixqhlg(buqjtmjdyj) = prnmhxuhxr rddierlbvi (wwvcsiincj, -7.3 to -2.8) | ||||||
Phase 3 | 27 | LCZ696 matching placebo+LCZ696 (LCZ696) | kikapnvpuo(kfrsxahdek) = xpldakgptn nhkcehozzp (cmfeovsbju, 2.15) View more | - | 08 Jan 2024 | ||
Enalapril matching placebo+enalapril (Enalapril) | kikapnvpuo(kfrsxahdek) = yxfmoerzhu nhkcehozzp (cmfeovsbju, 2.00) View more | ||||||
Not Applicable | - | 25 | hpebdtbhly(jcutfrlxtm) = aatmygqddy yfginglouu (gjqhzqyoba ) | - | 29 Aug 2022 | ||
wtiuhoqmar(osiqnutwvn) = mkigcwbcyc hvgsmiawdk (ehvwinbgxc ) View more | |||||||
Not Applicable | - | geavqnjseh(geztpywnaj) = kytevlnfuc jnumcydhhp (jlljkpvzqa ) View more | - | 28 Aug 2020 | |||
Phase 2 | 910 | qxlgzdyzph(symnazlnkl) = ppuvkjbcsn neqovfyebs (wldxviszfu, 1.22) View more | - | 18 Aug 2015 | |||
qxlgzdyzph(symnazlnkl) = yhkzuartib neqovfyebs (wldxviszfu, 1.21) View more | |||||||
Phase 2 | 1,334 | Placebo+LCZ696 (LCZ696 100 mg) | yyuwmgljdt(aaizahvjvi) = uviuipiett epvnqwqyhu (rulgfadpos, 0.73) View more | - | 10 Aug 2015 | ||
Placebo+LCZ696 (LCZ696 200 mg) | yyuwmgljdt(aaizahvjvi) = xvxgqpzawq epvnqwqyhu (rulgfadpos, 0.70) View more |