The efficacy and safety of different starting doses of enalapril in the treatment of non dialysis chronic kidney disease patients with moderate anemia: a randomized, open label, exploratory study

Start Date26 Mar 2025

Sponsor / Collaborator-

NCT06788314

/ RecruitingPhase 2IIT

A Single Center, Single Arm, Phase 2, Pilot Study to Investigate the Efficacy of the ACE Inhibitor Enalapril in Participants Aged 18-70 Years of Age With Painful Venous Malformations.

The goal of this clinical trial is to explore if enalapril can be used to treat painful venous malformations. The main question it aims to answer are:
- Can enalapril reduce pain and volume of the malformation and increase quality of life in patients with painful venous malformations?
Participants will:
Receive a dose of enalapril 5 mg once daily. If it doesn't have effect the dose of enalapril will be increased to 10 mg daily after 3 months.
The treatment duration will be 12 months, with an additional follow-up of 12 months.
The visit frequency will be after 1, 3, 6,9 and 12 months and then a follow up visit at 18 and 24 months.
Approximately 15 participants will be screened to achieve minimum 10 enrolled participants.

Start Date01 Feb 2025

Sponsor / Collaborator-

CTRI/2024/11/076455

/ Not yet recruitingNot ApplicableIIT

Evaluation of efficacy of add on short course oral enalapril in children with infrequently relapsing nephrotic syndrome aged 1-18 years - A open labelled randomized controlled trial - NIL

Start Date14 Nov 2024

Sponsor / Collaborator-

100 Clinical Results associated with Enalapril Maleate

100 Translational Medicine associated with Enalapril Maleate

100 Patents (Medical) associated with Enalapril Maleate

12,290

Literatures (Medical) associated with Enalapril Maleate

01 Aug 2025·Autonomic Neuroscience

Cardiovascular and neuroimmune adaptations to enalapril and exercise training: A comparative study in male and ovariectomized female spontaneously hypertensive rats

Article

Author: Araujo, Amanda Aparecida ; De Angelis, Kátia ; Ferreira, Maycon Junior ; do Amaral, Jônatas Bussador ; Nascimento Filho, Antonio Viana do ; Bernardes, Nathalia ; Irigoyen, Maria Cláudia ; Silva, Gabriel do Carmo

Antihypertensive drug and exercise training are commonly prescribed to treat arterial hypertension. However, there is a considerable gap in understanding how physiological mechanisms of male and female adapt to the combination of these approaches. Therefore, we focused to investigate sexual differences in cardiovascular, autonomic, inflammation and systemic oxidative stress adaptations in male and OVX female ovariectomized spontaneously hypertensive rats (SHR) treated with enalapril associated with moderate-intensity concurrent exercise training. Enalapril (3 mg/kg, diluted in drinking water) and exercise training (3 days/week, moderate intensity) was carried out for 8 weeks. Blood pressure (BP), heart rate (HR) and its variabilities were assessed. Serum and plasma were used for inflammatory and oxidative stress analyses. Enalapril, associated or not with exercise training, induced a reduction in diastolic and mean BP in both sexes; however, only the OVX female groups showed a reduction in systolic BP, as well as resting bradycardia. Both sexes showed improvements in BP and HR variability following the treatments; however, improvement in SD2/SD1 ratio, which indicates how much the heartbeats occur at irregular intervals, and in variance of systolic BP were observed only in trained groups. A higher spontaneous baroreflex sensitivity, as well as reduced IL-6/IL-10 were found only in the trained groups. Increased IL-10 was observed in male trained group (vs. other groups). Finally, combination enalapril and exercise training reduced systemic pro-oxidants such as NADPH oxidase and hydrogen peroxide. The findings of our study showed that OVX female SHR, after ovarian hormone deprivation, presented more pronounced effects on hemodynamics, BP variability, and anti-inflammatory profile than hypertensive males with the combination of treatments.BACKGROUNDResearchers are investigating how the body responds differently in males and females. These differences are also evident when examining how pharmacological and non-pharmacological approaches help the body control arterial hypertension. This study aimed to investigate how drug medication combined with exercise affects the heart's ability to self-regulate and how it relates to immune and oxidant defense, with a focus on differences in male and ovariectomized (OVX) female adaptations.METHODSThe study was conducted using hypertensive male and OVX female rats, allocated into: a) sedentary, b) enalapril, or c) enalapril plus exercise groups, totaling six groups (3 males and 3 OVX females, respectively). Enalapril (3 mg/kg/day) and exercise (aerobic and resistance exercises) were prescribed for eight weeks. The effects on blood pressure control, serum, and plasma were assessed.RESULTSAlthough both males and OVX females showed improvements in blood pressure after medication, combined or not with exercise, OVX females had better control of blood pressure and heart rhythm regulation. Furthermore, including an exercise program during medication treatment improved immune defense in OVX females only, as well as the levels of key enzymes involved in the process of organ damage development in both sexes.CONCLUSIONOVX female rats benefited more from the combination of medication and exercise compared to male rats. This suggests that OVX females may experience additional health benefits from the combination of antihypertensive approaches, highlighting the importance of understanding how exercise impacts the body differently in males and OVX females, which could contribute to better long-term disease management.

01 Jun 2025·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Sodium-glucose cotransporter 2 inhibitor partially improves brain mitochondrial function, but does not mitigate cognitive impairment in rats with myocardial infarction

Article

Author: Kongkaew, Aphisek ; Arunsak, Busarin ; Attachaipanich, Tanawat ; Pintana, Hiranya ; Chunchai, Titikorn ; Chattipakorn, Siriporn C ; Apaijai, Nattayaporn ; Chattipakorn, Nipon ; Pantiya, Patcharapong ; Thonusin, Chanisa ; Maneechote, Chayodom

Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are recommended to treat heart failure (HF) with the benefit of mitigating cognitive impairment in HF patients with type 2 diabetes. However, the underlying mechanisms are still unclear. This study aimed to investigate whether SGLT2i can improve cognitive function and synaptic plasticity in rats with myocardial infarction (MI) through attenuating inflammation, oxidative stress, impaired metabolism, and mitochondrial dysfunction in the brain. Male rats (n = 8/group) underwent either a sham operation or MI induced by permanent ligation of the left anterior descending coronary artery. MI rats with ejection fraction <50 % were divided into three groups to receive either a vehicle, SGLT2i (Dapagliflozin, 1 mg/kg), or angiotensin-converting enzyme inhibitor (Enalapril, 10 mg/kg, positive control) for four weeks. Cardiac function, cognitive function, synaptic plasticity, dendritic spine density, and brain biochemical changes were assessed at the end of the protocol. MI rats exhibited cardiac dysfunction, hippocampal-dependent cognitive impairment, impaired synaptic plasticity, and loss of dendritic spines. Brain oxidative stress, inflammation, and mitochondrial dysfunction were also observed in MI rats. Treatment with SGLT2i and ACEi improved cardiac function but failed to attenuate cognitive impairment, synaptic dysplasticity, and loss of dendritic spine density in MI rats. A decrease in brain glutamate level was found following MI, which can be restored by SGLT2i and ACEi. Only SGLT2i partially improved brain mitochondrial function. In summary, SGLT2i enhanced glutamate levels and partially improved mitochondrial function in the brain; however, these changes were insufficient to improve cognitive function in MI rats.

01 May 2025·European Journal of Pharmaceutics and Biopharmaceutics

The revival of the mini-tablets: Recent advancements, classifications and expectations for the future

Review

Author: Breitkreutz, Jörg ; Lura, Ard ; Lura, Valentinë ; Klingmann, Viviane

Mini-tablets have recently raised huge interest in pharmaceutical industry. The present review aims to identify the rational, the opportunities and challenges of this emerging small solid drug dosage form by a structured literature review following the PRISMA algorithm. In total, more than 5,000 literature and patent sources have been found starting with the very first in the 60s of the past century, followed by the first multiparticular products using mini-tablets with pancreatin (Panzytrat® by the former BASF subsidiary Knoll/Nordmark) authorized in 1985. There seems to be a second boost of common interest in the 2000s when clinical studies demonstrated that one or more mini-tablets could enable superior drug administration even in very young patients including neonates over the former gold standard, a liquid drug preparation. Several pharmaceutical companies immediately started clinical development programs using the mini-tablet concept and the first products have been recently authorized by the competent authorities. Superiority was given as the mini-tablets ease the swallowing procedure compared to conventional tablets, enable various modified drug release opportunities including taste-masking by film-coating technology and provide excellent drug stability compared to liquid oral dosage forms. Due to these product attributes they are particularly beneficial to children and their caregivers. Furthermore, there is potential for precise individual drug dosing by counting adequate amounts of the multiple drug carriers. Most recently, two novel products with different concepts were authorized by the EMA and entered the market which are highlighted in this review: the first orodispersible mini-tablet with enalapril maleate for congenital heart failure (Aqumeldi® from Proveca Pharma) and the first single unit mini-tablet with matrix-type controlled melatonin release for insomnia (Slenyto® from Neurim Pharmaceuticals). Our review reveals, that the majority of the published scientific papers use co-processed, ready-to-use excipients for the orodispersible mini-tablet formulations. However, traditional fillers such as microcrystalline cellulose or lactose have also been used for immediate release mini-tablets after adding a (super)disintegrant and a lubricant. The manufacturing of mini-tablets is conducted on conventional rotary tablet presses, predominantly equipped with multi-tip toolings to improve the yield or production speed. Scaling-up has been successfully realized from compaction simulators to pilot and production scale. Film-coatings enabling gastric resistance, taste masking or sustained-release properties have been realized in both fluid-bed and drum coaters using the same polymers as for conventional tablets. There is still a significant lack in regulatory guidance despite the recent success of the mini-tablet concept, starting from suitable characterization methods in the pharmacopoeias up to the design and conduct of clinical studies on mini-tablets.

News (Medical) associated with Enalapril Maleate

15 Feb 2024

·www.businesswire.com

GoodRx Now Offering 30 Common Heart Health Medications for Under $30

SANTA MONICA, Calif.--( BUSINESS WIRE )-- GoodRx , the leading destination for prescription savings in the U.S., today announced it is offering 30 of the most common heart health medications for under $30 at more than 70,000 pharmacies nationwide. 1 Cardiovascular disease is one of the most prominent conditions facing Americans, affecting nearly half of all U.S. adults. That’s why GoodRx is making it easier for all individuals, regardless of insurance status, to access savings on both generic and brand-name medications that mitigate the risk and impact of cardiovascular conditions such as coronary artery disease, high cholesterol, hypertension, and more. By helping people afford their prescriptions, GoodRx is improving health outcomes and reducing the overall strain on the healthcare system. GoodRx’s recent report - The GoodRx Effect - estimates that GoodRx has directly contributed to the prevention of at least 140,000 emergency room visits and 110,000 hospitalizations for major adverse cardiovascular events like heart attack and stroke. Save an average of 84% on common generic medications 2 The following is a sample list of common generic medications used to treat cardiovascular disease that are available for under $30 on GoodRx. MEDICATION LOWEST PRICE 3 AVG % SAVINGS 4 ACE Inhibitors Lisinopril (generic Prinivil and Zestril) $9.29 67% Enalapril (generic Epaned and Vasotec) $15.54 75% Beta Blockers Carvedilol (generic Coreg) $10.68 75% Metoprolol ER (generic Toprol XL) $11.15 74% Propranolol (generic Inderal) $10.96 71% Calcium Channel Blockers Amlodipine (generic Amvaz, Katerzia, and Norvasc) $9.15 80% Diltiazem ER (generic Cardizem CD) $13.43 74% Statins Atorvastatin (generic Lipitor) $10.10 83% Pravastatin (generic Pravachol) $14.53 74% Rosuvastatin (generic Crestor) $10.57 91% Access exclusive discounts and savings on brand-name drugs GoodRx offers incredible savings on brand-name medications that are often more costly and harder to obtain: MEDICATION SAVINGS* Entresto Pay as little as $10 for up to a 90-day supply Jardiance Pay as little as $10 per month Lodoco Pay as little as $30 for up to a 90-day supply Ozempic Pay as little as $25 per month Repatha Pay as little as $5 per month Soaanz Exclusive discount to save over 70% Toprol XL Exclusive discount to save up to 51% Xarelto Pay as little as $10 per fill *May require private or commercial insurance Learn more about cardiovascular disease from trusted doctors, pharmacists and health experts GoodRx Health is a go-to resource for understanding common heart conditions, risk factors, treatment options and associated savings. The GoodRx Heart Health Center provides credible, timely and actionable information to help people better manage their health. Each article is researched and written by a team of editorial experts, and clinical content is reviewed by a team of medical experts that includes physicians, pharmacists, and more. “Improving access to affordable medications is the most important thing we can do to improve Americans’ heart health. The second most important is ensuring access to helpful, accurate information,” said Karla Robinson, MD , Medical Editor at GoodRx. “Knowledge is power, so we create easy-to-understand content that people can actually use so they are better equipped to minimize the risk of disease, find affordable medications, stick to their treatment plans, and ultimately improve their overall health and wellbeing.” To find savings and trusted health information, download the GoodRx app or go to www.goodrx.com/hearthealth . About GoodRx GoodRx is the leading destination for prescription savings in the U.S. We offer consumers free access to transparent and lower prices for generic and brand medications, as well as comprehensive healthcare research and information. We also equip healthcare professionals with efficient ways to find and prescribe affordable medications. Since 2011, GoodRx has helped consumers save more than $65 billion and is one of the most downloaded medical apps over the past decade. GoodRx periodically posts information that may be important to investors on its investor relations website at https://investors.goodrx.com . We intend to use our website as a means of disclosing material nonpublic information and for complying with our disclosure obligations under Regulation FD. Accordingly, investors and potential investors are encouraged to consult GoodRx’s website regularly for important information, in addition to following GoodRx’s press releases, filings with the Securities and Exchange Commission (the “SEC”) and public conference calls and webcasts. The information contained on, or that may be accessed through, GoodRx’s website is not incorporated by reference into, and is not a part of, this press release. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, without limitation, statements regarding consumer savings; the benefits of our offerings to consumers, the U.S. healthcare system and GoodRx; and GoodRx’s plans, expectations and objectives. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, risks relating to our ability to achieve broad market education and change consumer purchasing habits, changes in medication pricing and pricing structures, our reliance on a limited number of industry participants, the competitive nature of our industry, risks related to government regulation of the internet, e-commerce, consumer data and privacy, information technology and cyber-security and the important factors discussed in the section entitled “Risk Factors” in GoodRx’s Annual Report on Form 10-K for the year ended December 31, 2022, as updated by our Quarterly Report on Form 10-Q for the quarter ended September 30, 2023, and our other filings with the Securities and Exchange Commission. These factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change. 1 Prices are subject to change at any time without notice. Prices may vary at different pharmacies, and for different forms, dosages, and quantities. 2 Calculated based on the difference between the average list price at a particular pharmacy and the average price paid by GoodRx consumers utilizing a GoodRx code at that same pharmacy in December 2023. 3 As of February 1, 2024. 4 Calculated based on the difference between the average list price at a particular pharmacy and the average price paid by GoodRx consumers utilizing a GoodRx code at that same pharmacy in December 2023.

AHA

08 Dec 2023

·synapse.patsnap.com

What are HMG-CoA reductase inhibitors and how do you quickly get the latest development progress?

HMG-CoA reductase is an enzyme that plays a crucial role in the human body's cholesterol synthesis pathway. It is responsible for catalyzing the conversion of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) to mevalonate, a key precursor in the production of cholesterol. By regulating the activity of HMG-CoA reductase, the body can control the amount of cholesterol synthesized. This enzyme is the target of statin drugs, which inhibit its activity, leading to a reduction in cholesterol levels. Maintaining proper HMG-CoA reductase function is essential for maintaining cholesterol homeostasis and preventing the development of cardiovascular diseases. HMG-CoA reductase inhibitors, also known as statins, are a class of drugs used to lower cholesterol levels in the body. The first statin, lovastatin, was approved by the FDA in 1987. Since then, several other statins have been developed, including atorvastatin, simvastatin, and rosuvastatin. Statins work by inhibiting the enzyme HMG-CoA reductase, which is involved in the production of cholesterol in the liver. By reducing cholesterol levels, statins can help prevent heart attacks, strokes, and other cardiovascular diseases. In addition to their cholesterol-lowering effects, statins have been shown to have other beneficial effects, such as reducing inflammation and improving endothelial function. They have also been investigated for their potential to treat other conditions, such as Alzheimer’s disease, multiple sclerosis, and certain types of cancer. The future of HMG-CoA reductase inhibitors looks promising, with ongoing research into new statins and other cholesterol-lowering drugs. Researchers are also investigating the potential of statins to treat other diseases, such as osteoporosis and autoimmune disorders. However, there are also concerns about the long-term effects of statin use, such as an increased risk of diabetes and liver damage. As such, further research is needed to fully understand the benefits and risks of these drugs. The mechanism of action of HMG-CoA reductase inhibitorsHMG-CoA reductase inhibitors are a class of drugs commonly known as statins. From a biomedical perspective, these drugs are used to lower cholesterol levels in the blood. They work by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in the production of cholesterol in the liver. By blocking this enzyme, statins reduce the amount of cholesterol synthesized in the body, leading to a decrease in LDL (low-density lipoprotein) cholesterol, often referred to as "bad" cholesterol. Lowering LDL cholesterol levels can help prevent the development of cardiovascular diseases such as heart attacks and strokes. Additionally, statins may have other beneficial effects, such as reducing inflammation and improving the function of blood vessels. HMG-CoA reductase inhibitors are commonly prescribed to individuals with high cholesterol levels or those at risk of cardiovascular diseases. Catalog of HMG-CoA reductase InhibitorsThe currently marketed HMG-CoA reductase inhibitors include: Ezetimibe/Pitavastatin CalciumAtorvastatin/FimasartanFenofibrate/Pitavastatin CalciumAmlodipine Besylate/Fimasartan Potassium Trihydrate/Rosuvastatin CalciumAmlodipine Besylate/Olmesartan Medoxomil/Rosuvastatin CalciumAtorvastatin Calcium Hydrate/Metformin HydrochlorideAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilPitavastatin MagnesiumAmlodipine/Losartan Potassium/Rosuvastatin CalciumValsartan/Rosuvastatin CalciumFor more information, please click on the image below. What is the purpose of using HMG-CoA reductase inhibitors?HMG-CoA reductase inhibitors, are used to lower cholesterol levels in the body. They are used adjunctively with diet and exercise to treat and manage hypercholesterolemia (high cholesterol in blood) and for primary and secondary prevention of coronary heart disease. For more information, please click on the image below to log in and search. How can I get the most recent advancements in HMG-CoA reductase inhibitors?In the Synapse database, you can keep abreast of the latest research and development advances of HMG-CoA reductase inhibitors anywhere and anytime, daily or weekly, through the "Set Alert" function. Click on the image below to embark on a brand new journey of drug discovery!

04 Sep 2023

·synapse.patsnap.com

ACE inhibitor -Overview of its R&D Progress | Competitive Landscape | Key Drug

ACE, or angiotensin-converting enzyme, plays a crucial role in the human body by regulating blood pressure and fluid balance. It converts angiotensin I, a hormone produced by the liver, into angiotensin II, a potent vasoconstrictor that narrows blood vessels. This process increases blood pressure and stimulates the release of aldosterone, a hormone that promotes sodium and water retention. ACE also breaks down bradykinin, a peptide that causes blood vessels to dilate and lowers blood pressure. Due to its involvement in these important physiological processes, ACE inhibitors are commonly used in the treatment of hypertension, heart failure, and other cardiovascular conditions. ACE Competitive LandscapeAccording to the data provided by Patsnap Synapse-Global Drug Intelligence Database: the following figure shows that as of 2 Sep 2023, there are a total of 163 ACE drugs worldwide, from 159 organizations, covering 68 indications, and conducting 810 clinical trials. 👇Please click on the picture link below for free registration or login directly if you have freemium accounts, you can browse the latest research progress on drugs , indications, organizations, clinical trials, clinical results, and drug patents related to this target. The analysis of the target ACE reveals a competitive landscape with companies like Les Laboratoires Servier SAS, CHIESI Farmaceutici SpA, and Viatris Inc. leading in R&D efforts. The focus of research is primarily on indications like hypertension, heart failure, and cardiovascular diseases. Small molecule drugs dominate the market, but there is also potential in other drug types like peptide drug conjugates and monoclonal antibodies. The European Union, China, the United States, and Japan are the key regions driving the development of ACE-related drugs. China, in particular, has shown significant progress. Overall, the target ACE presents opportunities for further research and development, with potential for innovative drugs and intense competition in the market. Key Drug: CaptoprilCaptopril is a small molecule drug that targets ACE and is used in the treatment of various cardiovascular, endocrinology, and urogenital diseases. It has been approved for multiple indications, including essential hypertension, hypertensive nephropathy, heart failure, and myocardial infarction. This wide range of indications highlights the versatility and effectiveness of Captopril in managing different conditions related to the cardiovascular system and metabolic disorders. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. Captopril was first approved in Japan in January 1980, making it a well-established drug with a long history of use. The drug has achieved the highest phase of approval both globally and in China, indicating its widespread acceptance and recognition by regulatory authorities. This suggests that Captopril has undergone rigorous testing and evaluation to ensure its safety and efficacy Enalapril MaleateEnalapril Maleate is a small molecule drug that primarily targets ACE. It is used in the treatment of various therapeutic areas including immune system diseases, infectious diseases, nervous system diseases, cardiovascular diseases, and urogenital diseases. The drug has been approved for the treatment of ventricular dysfunction, left, angina pectoris, myocardial infarction, encephalomyelitis, eastern equine, immune system diseases, heart failure, essential hypertension, hypertension, renal, hypertension, renovascular, and hypertension. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. Enalapril Maleate has a long history of use since its first approval in 1985. Its broad therapeutic areas and indications make it a versatile drug in the field of biomedicine. The drug's approval in both the global and Chinese markets further solidifies its position as a widely recognized and accepted treatment option. As a small molecule drug targeting ACE, Enalapril Maleate plays a crucial role in managing various diseases and conditions, particularly those related to the immune system, cardiovascular system, and nervous system. LisinoprilLisinopril is a small molecule drug that falls under the therapeutic area of cardiovascular diseases. It primarily targets ACE and is used to treat various conditions related to the heart and blood vessels. The drug has been approved for use in multiple indications, including acute myocardial infarction, kidney diseases, chronic heart failure, hypertension, and heart failure. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. Lisinopril was first approved in the United States in December 1987 and has been developed by Merck Sharp & Dohme Corp. and AstraZeneca PLC. Lisinopril has reached the highest phase of development, indicating its safety and efficacy, and has received regulatory approval both globally and in China.

100 Deals associated with Enalapril Maleate

External Link

KEGG	Wiki	ATC	Drug Bank
D00621	Enalapril Maleate	C09AA02	DB00584

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Ventricular Dysfunction, Left	United States	Azurity Pharmaceuticals, Inc.	20 Sep 2016
Angina Pectoris	China	Merck Sharp & Dohme Corp.	15 Dec 2000
Myocardial Infarction	China	Merck Sharp & Dohme Corp.	15 Dec 2000
Encephalomyelitis, Eastern Equine	United States	Wockhardt Ltd.	22 Aug 2000
Immune System Diseases	United States	Wockhardt Ltd.	22 Aug 2000
Heart Failure	Japan	Organon & Co.	29 Mar 1991
Essential Hypertension	Japan	Organon & Co.	30 Apr 1986
Hypertension, Renal	Japan	Organon & Co.	30 Apr 1986
Hypertension, Renovascular	Japan	Organon & Co.	30 Apr 1986
Hypertension	United States	Bausch Health US LLC	24 Dec 1985

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Cardiomyopathy, Dilated	Phase 1	Hungary	Ethicare, Inc.	01 Jan 2016
Cardiomyopathy, Dilated	Phase 1	Netherlands	Ethicare, Inc.	01 Jan 2016
Heart Failure	Phase 1	Hungary	Ethicare, Inc.	01 Jan 2016
Heart Failure	Phase 1	Serbia	Ethicare, Inc.	01 Jan 2016
Heart Failure	Phase 1	United Kingdom	Ethicare, Inc.	01 Jan 2016
Cardiomyopathy, Dilated	Preclinical	United Kingdom	Ethicare, Inc.	01 Jan 2016
Cardiomyopathy, Dilated	Preclinical	Austria	Ethicare, Inc.	01 Jan 2016
Cardiomyopathy, Dilated	Preclinical	Serbia	Ethicare, Inc.	01 Jan 2016
Heart Failure	Preclinical	Austria	Ethicare, Inc.	01 Jan 2016
Heart Failure	Preclinical	Netherlands	Ethicare, Inc.	01 Jan 2016

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04236258 (Pubmed \| Am J Obstet Gynecol MFM)	Phase 4	-	47	Enalapril 10 mg daily	vkeuavsico(fbrobkqoyo) = yjuyfvilqu zdvrngwqhu (jvkzbturjf )	Negative	01 Dec 2023
				Nifedipine 30 mg daily	vkeuavsico(fbrobkqoyo) = esbioheivy zdvrngwqhu (jvkzbturjf )
ESC2023	Not Applicable	First line	-	Perindopril-based regimens	jcukxdwbwe(mtisxrozqu) = flsfapquqg brhxkfnzqs (mtgwljiyme, 87–8973)	-	27 Aug 2023
				Losartan-based regimens	jcukxdwbwe(mtisxrozqu) = olafbozbtb brhxkfnzqs (mtgwljiyme, 104–9365)
NCT04236258 (CTgov)	Phase 4	Pre-Eclampsia	94	NIFEdipine ER (Nifedipine)	lxaqdsahlk(wgmusrmzin) = ndxkxpobpu tpymvbztdn (ugsrqfpfqg, jzryjesxsd - prgqsuqqar) View more	-	30 Nov 2022
				Enalapril (Enalapril)	lxaqdsahlk(wgmusrmzin) = aqstzlszsj tpymvbztdn (ugsrqfpfqg, bemnkqtaih - ozpgajnbbw) View more
ESC2021	Not Applicable	Hematologic Neoplasms	60	Sacubitril/Valsartan	fatgvkwgde(mezajyseof) = bzscaztbre cqgrchmhqr (lzvewmkjbo )	Positive	09 Dec 2021
				Enalapril	fatgvkwgde(mezajyseof) = npwpoctagf cqgrchmhqr (lzvewmkjbo ) View more
NCT02874794 (EVALUATE-HF, CTgov)	Phase 4	Heart failure with normal ejection fraction \| Hydrops Fetalis \| Stiffness	465	Enalapril (Enalapril (Double-Blind Phase))	piiyjzbjif(lgaldkucin) = gvyjbkxrar sszwrqlwjv (wrbbuflmin, mzgdlijnor - pehwqegdlw) View more	-	19 Mar 2020
				Valsartan+Sacubitril (Sacubitril/Valsartan (Double-Blind Phase))	piiyjzbjif(lgaldkucin) = jvmctjotzj sszwrqlwjv (wrbbuflmin, mxjiovjaxa - vayjnpcgyg) View more
NCT01754909 (CTgov)	Phase 2	Radiation Pneumonitis \| Lung Cancer \| Fibrosis	50	enalapril (Enalapril)	ojzvjnzxgw(dvjqhdhpdw) = efedgoqwcw oyomceezal (ajwjxfuiuu, alajyhzgsl - jhwgmginxb) View more	-	01 Oct 2019
				placebo (Placebo)	ojzvjnzxgw(dvjqhdhpdw) = eogzvmekxk oyomceezal (ajwjxfuiuu, chynvoewso - zohvgklgms) View more
NCT00895414 (CTgov)	Not Applicable	Breast Cancer	19	doxorubicin hydrochloride+enalapril maleate (Doxorubicin Alone First, Then Doxorubicin With Enalapril)	ixkstfgwfm(tihoxpfifw) = rewwznysvd vzwfrtpqbm (qziqawcbin, atewfukmqo - ewkdbbkwln) View more	-	08 May 2019
				doxorubicin hydrochloride+enalapril maleate (Doxorubicin With Enalapril First, Then Doxorubicin Alone)	ixkstfgwfm(tihoxpfifw) = xitoxnfazp vzwfrtpqbm (qziqawcbin, btvsfvantk - oqbnfgrivf) View more
NCT01035255 (PARADIGM-HF, Pubmed \| Eur J Heart Fail)	Phase 3	Heart failure with reduced ejection fraction \| Chronic heart failure	8,399	Sacubitril/valsartan	skzkxaxwpp(ztxhwfustp) = vkdxrmhaqt fhhvckdhom (cewgdgswas )	-	01 Mar 2019
				Enalapril	skzkxaxwpp(ztxhwfustp) = eqexkbvcnw fhhvckdhom (cewgdgswas )
ESC2018	Not Applicable	Chronic heart failure First line	-	Enalapril	(vyudmmdgdg) = gzlnkfghhw otnvbgvhgk (fbhnajdmdr )	-	26 May 2018
				Lisinopril	(vyudmmdgdg) = idwkofspyq otnvbgvhgk (fbhnajdmdr )
NCT01669434 (CTgov)	Phase 4	Hypotension	291	LISINOPRIL+Captopril+ENALAPRILAT+BENAZEPRIL HYDROCHLORIDE+PERINDOPRIL ERBUMINE+RAMIPRIL+QUINAPRIL HYDROCHLORIDE+Enalapril Maleate+Perindopril Arginine+FOSINOPRIL SODIUM+TRANDOLAPRIL+MOEXIPRIL HYDROCHLORIDE (ACEI Omission)	sxsesvsglk(clreyjycmz) = esjmcdpqah fnrmbbgegx (apeedffujn, admtcwqkgw - cfhupzpjtb) View more	-	11 Dec 2017
				ACEI continuation (ACEI Continuation)	sxsesvsglk(clreyjycmz) = bwuqzujixz fnrmbbgegx (apeedffujn, sbqdtifepw - htjimdoxiq) View more

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Enalapril Maleate

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