Last update 21 Nov 2024

Combretastatin A1 Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CA1P, Combrestatin A1 diphosphate, Combretastatin A-1 bis(phosphate)
+ [6]
Target
Mechanism
Tubulin modulators
Active Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationRare Pediatric Disease (US), Fast Track (US), Orphan Drug (US)
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Structure

Molecular FormulaC18H22O12P2
InChIKeyGSOXMQLWUDQTNT-WAYWQWQTSA-N
CAS Registry288847-35-8
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neoplasm MetastasisPhase 2
AU
01 Jul 2009
Advanced Malignant Solid NeoplasmPhase 2
GB
01 Jul 2005
Hepatocellular CarcinomaPhase 2--
Acute Myeloid LeukemiaIND Approval
US
01 Oct 2015
Myelodysplastic SyndromesIND Approval
US
01 Oct 2015
Relapsing acute myeloid leukemiaIND Approval
US
01 Oct 2015
Malignant ascitesIND Approval
AU
09 May 2013
Liver CancerIND Approval
AU
02 Apr 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
26
(iwddzqgfqx) = xpxorwnwsf vijirfyceg (qgebbfavrm )
Positive
27 Dec 2019
Phase 1
29
(niipumyjbi) = 9.76 mg/m2 ombination with 1 g/m2 ARA-C wpvytmyvga (hsjjdcvnnh )
Positive
26 Dec 2019
Phase 1/2
26
(mkzwcvdfxb) = zshrogggja pnqrqxnduu (hcxkmgyjwa )
Positive
23 Dec 2019
Not Applicable
-
sdedbxrsse(miyxiudceo) = extensive areas of necrosis and hemorrhaging compared to untreated controls rlxxjycwlp (lntoqmesfk )
-
24 Jul 2012
(Untreated controls)
Phase 1
11
hiruqkiocp(mcqrjtczyl) = showed significant reduction in Ktrans in one patient (0.24mg/m^2) fsexdgoqpg (xusaccyrdp )
-
20 Jun 2007
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Clinical Trial

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Approval

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Regulation

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