Delving into the Latest Updates on Iofetamine Hydrochloride I-123 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug, Diagnostic radiopharmaceuticals

Synonyms

IMP, Iodine iofetamine (123I), Iofetamine (123 I)

+ [14]

Target-

Mechanism

SPECT(Single-photon emission-computed tomography enhancers)

Therapeutic Areas

Other Diseases

Active Indication

Diagnostic agents

Inactive Indication

Stroke

Originator Organization

Medi-Physics, Inc.

Active Organization

Nihon Medi-Physics Co., Ltd.

Inactive Organization

IMP, Inc.

Drug Highest PhaseApproved

First Approval Date

JP (30 Apr 1986),

Diagnostic agents

Regulation-

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Structure

Molecular FormulaC12H18IN

InChIKeyISEHJSHTIVKELA-DCWJVSPSSA-N

CAS Registry75917-92-9

View All Structures (2)

A novel ratiometric electrochemical sensor based on methylene blue-functionalized ZIF-8/Au nanoparticle composites (ZIF-8@MB/AuNPs) was constructed for reliable detection of methyl parathion (MP). The ZIF-8@MB/AuNPs composites were prepared by a simple and mild room-temperature method. Here, ZIF-8 was served as a support for loading functional nanomaterials, which helps to improve the adsorption and accumulation capacity for MP. The functional electroactive molecule methylene blue (MB) was adopted to produce a stable reference signal and form a ratiometric sensing strategy, offering more accurate and reliable detection results. The decoration of Au nanoparticles can effectively enhance the conductivity and catalytic activity of the composites. The obtained ZIF-8@MB/AuNPs composites exhibited a superior electrochemical catalytic performance toward MP. According to the ratiometric signal of I_MP/I_MB, the developed sensor offered a detection range of 0.05-30 μg mL^-1 and exhibited favorable selectivity, reproducibility and stability, and satisfactory applicability in vegetable samples.

06 Nov 2024·Antimicrobial Agents and Chemotherapy

Assessment of the activity and mechanisms of resistance to cefiderocol and combinations of β-lactams and the novel β-lactamase inhibitors avibactam, taniborbactam, zidebactam, nacubactam, xeruborbactam, and ANT3310 in emerging double-carbapenemase-producing Enterobacterales

Article

Author: Alonso-García, Isaac ; López-Cerero, Lorena ; Rodríguez-Pallares, Salud ; González-Pinto, Lucía ; Bou, Germán ; Pérez-Vázquez, María ; Pascual, Álvaro ; Arca-Suárez, Jorge ; Vázquez-Ucha, Juan Carlos ; Aracil, Belén ; Beceiro, Alejandro ; Outeda-García, Michelle ; Oteo-Iglesias, Jesús ; Sánchez-Peña, Lucía ; López-Hernández, Inmaculada ; Blanco-Martín, Tania ; Aja-Macaya, Pablo

ABSTRACT We aimed to investigate the activity of and mechanisms of resistance to cefiderocol and innovative β-lactam/β-lactamase inhibitor combinations in a nationwide collection of double-carbapenemase-producing Enterobacterales. In all, 57 clinical isolates co-producing two carbapenemases collected from Spanish hospitals during the period 2017–2022 were analyzed. Minimum inhibitory concentration (MIC) values for ceftazidime, ceftazidime/avibactam, aztreonam, aztreonam/avibactam, aztreonam/nacubactam, cefiderocol, cefepime, cefepime/taniborbactam, cefepime/zidebactam, cefepime/nacubactam, imipenem, imipenem/relebactam, meropenem, meropenem/vaborbactam, meropenem/xeruborbactam, and meropenem/ANT3310 were determined by reference broth microdilution. Genetic drivers of resistance were analyzed by whole-genome sequencing (WGS). The collection covered nine carbapenemase associations: VIM + OXA-48 (21/57), NDM + OXA-48 (11/57), KPC + VIM (10/57), KPC + OXA-48 (6/57), IMP + OXA-48 (3/57), NDM + KPC (2/57), NDM + VIM (2/57), NDM + GES (1/57), and KPC + IMP (1/57). Ceftazidime/avibactam, imipenem/relebactam, and meropenem/vaborbactam were the least active options. Aztreonam/avibactam and aztreonam/nacubactam were active against the whole collection and yielded MIC 50 /MIC 90 values of ≤0.25/0.5 mg/L and 1/2 mg/L, respectively. Cefepime/zidebactam (56/57 susceptible), meropenem/xeruborbactam (56/57 susceptible), cefepime/nacubactam (55/57 susceptible), and cefiderocol (53/57 susceptible) were also highly active, with MIC 50 /MIC 90 values ranging from ≤0.25–2 mg/L to 2–4 mg/L, respectively. Meropenem/ANT3310 (MIC 50 /MIC 90 = 0.5/≥64 mg/L; 47/57 susceptible) and cefepime/taniborbactam (MIC 50 /MIC 90 = 0.5/16 mg/L; 44/57 susceptible) also retained high levels of activity, although they were affected by NDM-type enzymes in combination with porin deficiency. Our findings highlight that cefiderocol and combinations of β-lactams and the novel β-lactamase inhibitors avibactam, nacubactam, taniborbactam, zidebactam, xeruborbactam, and ANT3310 show promising activity against double-carbapenemase-producing Enterobacterales.

01 Oct 2024·Experimental Cell Research

The reduction of imidazole propionate induced by intermittent fasting promotes recovery of peripheral nerve injury by enhancing migration of Schwann cells

Article

Author: Liu, Kunyu ; Shao, Tuo ; Zhong, Xin ; Yin, Xiaoyu ; Gao, Qichang ; Shen, Hongtao ; Zhang, Zhenyu ; Tang, Weilong

Peripheral nerve injury (PNI) accompanied with sensory and motor dysfunction has serious effect on the quality of life of patients. Intermittent fasting (IF), as a dietary pattern, has rarely been reported to influence imidazole propionate (ImP), a microbial metabolite, in vivo. To date, the link between ImP and PNI is unknown. This study aimed to explore the impact of ImP on the recovery after PNI and determine whether IF could reduce the concentration of ImP in vivo. Sciatic nerve injury rat model and RSC96 cells were utilized with 16s RNA seq, HE staining, CCK-8 assay, Western blot (WB), Transmission electron microscopy (TEM), immunofluorescence, transwell and scratch wound healing assays as read outs. WB, TEM, transwell and wound healing assay showed an inhibitory effect of ImP on autophagy and migration of Schwann cells. This negative effect on migration was reversed by rapamycin. Detection of p-Erk and p-mTOR confirmed that the MAPK/Erk/mTOR pathway was involved in this process. In vivo, IF changed the composition of gut microbiome, including bacteria related to ImP production and reduced the concentration of ImP in serum. In sum, IF influenced the composition of gut microbiome and reduced the concentration of ImP in vivo. The reduction of ImP promoted migration of SCs through enhancing autophagy which involved MAPK/Erk/mTOR pathway.

100 Deals associated with Iofetamine Hydrochloride I-123

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