Drug Type Cell therapy |
Synonyms- |
Target- |
Mechanism Cell replacements |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhasePendingPhase 1 |
First Approval Date- |
Regulation- |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Solid tumor | Phase 1 | BE | 29 Jan 2018 |
NCT03707808 (ESMO2024) Manual | Phase 1 | 6 | Autologous CD1c(BDCA-1)+/CD141(BDCA-3)+myeloid dendritic cells (myDC) with AS01B plus ipilimumab (IPI) and nivolumab (NIVO) | (nrnvopaued) = Treatment related adverse events (TRAE) included transient grade 1/2 injection site reactions and constitutional symptoms. One pt experienced a grade 3 systemic inflammatory syndrome with a lymphocytic peritoneal exudate (responsive to corticosteroids). There were no grade 4-5 TRAE. zcfyfwnmne (yvaiyeuznd ) | Positive | 14 Sep 2024 | |
NCT03707808 (Pubmed) Manual | Phase 1 | Refractory Melanoma CD1c (BDCA-1) | CD141 (BDCA-3) | 8 | (ikeveqeplo) = zlsxaklnwx wcfiszxnyr (jjkikccjub ) View more | Positive | 11 Jan 2024 | |
NCT03707808 (SITC2022) Manual | Phase 1 | BRAF V600 mutation-positive Melanoma BRAF V600 | 8 | (dcngeqesqr) = gqqbbnpxrf brvgwqivkk (damcuvymhd, 5.193 - 15.007) View more | Positive | 01 Nov 2022 | |
NCT03707808 (ASCO2019) Manual | Phase 1 | HR-positive/HER2-low Solid Tumors Second line | 6 | (soezgowhxj) = transient G 2 local pain at injection site in 2 pts, G1 pruritus in 2 pts, G2 pneumonitis in 1 pt, G1 rash in 1 pt, pruritus and redness of the skin overlaying the injected lesion in 1 pt udjlyjxiyu (cwwrpzbetg ) View more | Positive | 31 May 2019 |