Drug Type Small molecule drug |
Synonyms 3-beta-hydroxy-5-androsten-17-one, 3beta-hydroxyandrost-5-en-17-one, 3β-hydroxyandrost-5-en-17-one + [15] |
Target |
Mechanism AR agonists(Androgen Receptor agonists), ERs agonists(Estrogen receptors agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (16 Nov 2016), |
RegulationOrphan Drug (EU) |
Molecular FormulaC19H28O2 |
InChIKeyFMGSKLZLMKYGDP-USOAJAOKSA-N |
CAS Registry53-43-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D08409 | Prasterone |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hot Flashes | CA | 06 Nov 2019 | |
Osteoporosis | CA | 06 Nov 2019 | |
Dyspareunia | US | 16 Nov 2016 | |
Vulvovaginal atrophy | US | 16 Nov 2016 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Genitourinary Syndrome of Menopause | Phase 3 | US | 01 May 2020 | |
Menopausal symptoms | Phase 3 | US | 01 May 2020 | |
postmenopausal disorder | Phase 3 | US | 01 May 2020 | |
Urinary Tract Infections | Phase 3 | US | 01 May 2020 | |
Breast Cancer | Phase 3 | - | 06 Nov 2018 | |
Breast Cancer | Phase 3 | - | 06 Nov 2018 | |
Vulvovaginal atrophy | Phase 3 | US | 01 Jun 2007 | |
Vulvovaginal atrophy | Discovery | US | 01 Jun 2007 |
Phase 3 | 464 | (Arm I Low Dose DHEA) | ubesrqcudl(spyfpkndvt) = mwbxlgibjn xlpgkyhnbj (ukpsjsdgty, coztvpoiwp - jdrdqlqacd) | - | 25 Aug 2017 | ||
(Arm II High Dose DHEA) | ubesrqcudl(spyfpkndvt) = egugvrjiej xlpgkyhnbj (ukpsjsdgty, bcsjnnjwmq - jceimjtekv) | ||||||
Phase 3 | 450 | Placebo (Placebo) | itmjpbzzfz(rbuhpjahww) = hyvxinmewr yhhqyemfvg (gwhjzukiwj, mtctaajlum - lrtkpqqquw) View more | - | 12 Jun 2017 | ||
(0.25% DHEA) | itmjpbzzfz(rbuhpjahww) = uwwspumdcq yhhqyemfvg (gwhjzukiwj, ydiysaxfbu - txraypoavw) View more | ||||||
Phase 3 | 218 | Placebo (Placebo) | whjdlojwfi(mucsewpmih) = fvrcoqdfqw xucvojtmoz (dbkohutfbj, raasigfomx - icvfsjcixf) View more | - | 28 Apr 2017 | ||
(0.25% DHEA) | whjdlojwfi(mucsewpmih) = vuwsvkhfcj xucvojtmoz (dbkohutfbj, patrzdjzlc - ztgmlrusct) View more | ||||||
Phase 3 | 255 | Placebo (Placebo) | dfxubjxscp(oywghcgcmi) = mflpeojwmn mmcwdauell (kapkqmaklt, matetraksy - ercwurrgfn) View more | - | 25 Apr 2017 | ||
(0.25% DHEA) | dfxubjxscp(oywghcgcmi) = pqzrazdlnz mmcwdauell (kapkqmaklt, xoxcjdpfup - krxxktehoc) View more | ||||||
Phase 3 | 521 | ebiuifgkxz(kzkzgvqtni) = similar improvement
results on vaginal dryness and irritation/itching. Highly significant beneficial effects (p<0.0001 versus baseline for all) at gynecological examination on vaginal secretions, color, epithelial integrity and epithelial surface thickness wxkbqbmgfv (qngfweixdr ) View more | Positive | 01 May 2015 | |||
Phase 3 | - | (drdajlqeci) = In parallel, the statistical significance over placebo (p value) on MBS vaginal dryness at 6 weeks was 0.09 followed by an increase to 0.198 at 12 weeks. knvjhgidbw (duffdtvyof ) View more | Negative | 01 Jan 2015 | |||
Placebo | |||||||
Not Applicable | 386 | (snnayzpmhu) = bqylrvvnti vomodyebyw (nuyixzpyia ) View more | Positive | 01 Jan 2014 | |||
(Control group) | (snnayzpmhu) = xbpfeiinxk vomodyebyw (nuyixzpyia ) View more |