Randomized, Double Blind, Placebo Controlled Study of Parallel Groups to Evaluate the Effect of Chronic Supplementation of L-arginine in the Muscular Performance.

The primary purpose of this study is to evaluate the effect of oral administration of L-arginine in the muscular fatigue of the quadriceps, expressed in terms of the Fatigue Resistance Factor (FRF). The secondary purpose of this study is to evaluate the effect of oral administration of L-arginine in the muscular force the quadriceps.

Start Date01 Oct 2008

Sponsor / Collaborator

Sanofi

100 Clinical Results associated with L-Arginine/L-Aspartate

100 Translational Medicine associated with L-Arginine/L-Aspartate

100 Patents (Medical) associated with L-Arginine/L-Aspartate

668

Literatures (Medical) associated with L-Arginine/L-Aspartate

01 Apr 2024·Biomaterials Advances

Co-release of nitric oxide and L-arginine from poly (β-amino ester)-based adhesive reprogram macrophages for accelerated wound healing and angiogenesis in vitro and in vivo

Article

Author: Kharazi, Anousheh Zargar ; Javanmard, Shaghayegh Haghjooy ; Varshosaz, Jaleh ; Heydari, Parisa ; Kharaziha, Mahshid

Recently, insufficient angiogenesis and prolonged inflammation are crucial challenges of chronic skin wound healing. The sustained release of L-Arginine (L-Arg) and nitric oxide (NO) production can control immune responses, improve angiogenesis, enhance re-epithelialization, and accelerate wound healing. Here, we aim to improve wound healing via the controlled release of NO and L-Arg from poly (β-amino ester) (PβAE). In this regard, PβAE is functionalized with methacrylate poly-L-Arg (PAMA), and the role of PAMA content (50, 66, and 75 wt%) on the adhesive properties, L-Arg, and NO release, as well as collagen deposition, inflammatory responses, and angiogenesis, is investigated in vitro and in vivo. Results show that the PAMA/ PβAE could provide suitable adhesive strength (~25 kPa) for wound healing application. In addition, increasing the PAMA content from 50 to 75 wt% results in an increased release of L-Arg (approximately 1.4-1.7 times) and enhanced NO production (approximately 2 times), promoting skin cell proliferation and migration. The in vitro studies also show that compared to PβAE hydrogel, incorporation of 66 wt% PAMA (PAMA 66 sample) reveals superior collagen I synthesis (~ 3-4 times) of fibroblasts, controlled pro-inflammatory and improved anti-inflammatory cytokines secretion of macrophages, and accelerated angiogenesis (~1.5-2 times). In vivo studies in a rat model with a full-thickness skin defect also demonstrate the PAMA66 sample could accelerate wound healing (~98 %) and angiogenesis, compared to control (untreated wound) and Tegaderm™ commercial wound dressing. In summary, the engineered multifunctional PAMA functionalized PβAE hydrogel with desired NO and L-Arg release, and adhesive properties can potentially reprogram macrophages and accelerate skin healing for chronic wound healing.

01 Apr 2024·Neurotoxicity Research

Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats

Article

Author: Aghaei, Fariba ; Falahi, Farshad ; Wong, Alexei ; Ali Askari, Ali ; Zargani, Mehdi ; Dehghannayeri, Zahra ; Sarshin, Amir ; Arabzadeh, Ehsan ; Feizolahi, Foad

The objective of this study was to evaluate the combined and independent effects of exercise training and L-Arginine loaded chitosan nanoparticles (LA CNPs) supplementation on hippocampal Tau, App, Iba1, and ApoE gene expression, oxidative stress, β-secretase enzyme activity, and hippocampus histopathology in aging rats. Thirty-five male Wistar rats were randomly assigned to five groups (n = 7 in each): Young (8 weeks old), Old (20 months old), old + L-arginine supplementation (Old Sup), old + exercise (Old Exe) and old + L-arginine supplementation + exercise (Old Sup + Exe). LA CNPs were administered to the supplement groups through gavage at a dosage of 500 mg/kg/day for 6-weeks. Exercise groups were subjected to a swimming exercise program five days/week for the same duration. Upon the completion of their interventions, the animals underwent behavioral and open-field task tests and were subsequently sacrificed for hippocampus genetic and histopathological evaluation. For histopathological analysis of brain, Cresyl violet staining was used. Congo Red staining was employed to confirm amyloid plaques in the hippocampus. Expressions of Tau, App, Iba1, and ApoE genes were determined by real-time PCR. In contrast to the Old group, Old Exe and Old Sup + Exe groups spent more time in the central space in the open field task (p < 0.05) and have more live cells in the hippocampus. Old rats (Old, Old Sup and Old Exe groups) exhibited a significant Aβ peptide accumulation and increases in APP, Tau, Iba1, APOE-4 mRNA and MDA, along with decreases in SOD compared to the young group (p < 0.05). However, LA CNPs supplementation, exercise, and their combination (Old Sup, Old Exe and Old Sup + Exe) significantly reduced MDA, Aβ plaque as well as APP, Tau, Iba1, and APOE-4 mRNA compared to the Old group (p < 0.05). Consequently, the administration of LA CNPs supplements and exercise might regulate the risk factors of hippocampus cell and tissue.

01 Feb 2024·animal

Characterization of taste sensitivities to amino acids and sugars by conditioned taste aversion learning in chickens

Article

Author: Yoshida, Yuta ; Fujishiro, Shu ; Kawabata, Fuminori ; Kawai, Ryota

Taste plays an essential role in regulating the feeding behaviors of animals. The present study aimed to characterize the taste sensory profiles of amino acids and sugars in chickens. To achieve this, we employed a conditioned taste aversion learning method, which is characterized by a specific pairing of gastrointestinal malaise and taste perception. Our findings revealed that chickens were able to learn to avoid L-Val, L-Lys, and L-His through conditioned taste aversion learning, and exhibited a strong aversion to L-Arg. These results suggest that chickens are primarily sensitive to basic amino acids, including L-Lys, which is a crucial limiting amino acid in feeds. Interstingly, this sensitivity to basic amino acids in chickens contrasts with humans, who are mainly sensitive to acidic amino acids as umami taste. Furthermore, despite the absence of a mammalian sweet taste receptor gene in the chicken genome, we demonstrated that chickens learned to avoid glucose, galactose, sucrose, and maltose by conditioned taste aversion learning. Taken together, the present study provides the idea that chickens possess a gustatory perception toward specific amino acids and sugars for the detection of beneficial nutrients in their feeds.

100 Deals associated with L-Arginine/L-Aspartate

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Inflammation	NDA/BLA	UA	Ukrainian Medical Stomatological Academy	20 Oct 2017
Periodontitis	NDA/BLA	UA	Ukrainian Medical Stomatological Academy	20 Oct 2017
Muscle fatigue	NDA/BLA	BR	Sanofi	05 Nov 2008

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ESC2018	Not Applicable	Metabolic Syndrome	62	L-Arginine aspartate	wvgxprarwm(clgqhpqhvk) = phygmhcvwf sszbhnyhue (fkmzzkcils ) View more	-	26 Aug 2018
				l-arginine aspartate	wvgxprarwm(clgqhpqhvk) = dunshsuwlw sszbhnyhue (fkmzzkcils ) View more
EULAR2015	Not Applicable	Rheumatoid Arthritis \| Hypertension	42	L-Arginine aspartate + standard treatment	(mgvltyqqpk) = pzkborbqof xjyepdqywo (lykrgzgstw )	Positive	10 Jun 2015
				Standard treatment	(mgvltyqqpk) = ghilvciqxm xjyepdqywo (lykrgzgstw )
FP098 (ERA2015)	Not Applicable	-	27	L-Arginine aspartate 30 ml/day	(kelyctvlxm) = klnhtdjuex upcgcvlzad (fokkhdirym ) View more	Positive	21 May 2015
				Standard treatment	(kelyctvlxm) = gfuvtfcnpm upcgcvlzad (fokkhdirym ) View more
EULAR2011	Not Applicable	Rheumatoid Arthritis	40	Methotrexatum	xtpkyupsyb(ditfwvkdjr) = xtkgxjbwiz awtmqrgikl (gijtqoyjqd ) View more	Positive	25 May 2011
				NO-donators (Arginine hydrochloride and L-Arginine aspartate)	xtpkyupsyb(ditfwvkdjr) = skfgkidpig awtmqrgikl (gijtqoyjqd )

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