Q4 · MEDICINE
Article
Author: Chong-Neto, Herberto ; Correia de Sousa, Jaime ; Novakova, Sylvia ; Canonica, Giorgio Walter ; Nedeva, Denislava ; Braido, Fulvio ; Tiotiu, Angelica ; Dubuske, Lawrence ; Ivancevich, Juan Carlos ; Cosini, Filippo ; Bikov, Andras ; Labor, Marina ; Mihaicuta, Stefan ; Rosario, Nelson ; Urrutia Pereira, Marilyn ; Bernstein, Jonathan A. ; Kaidashev, Igor ; Kowal, Krzysztof ; Emelyanov, Alexander ; Steiropoulos, Paschalis ; Novakova, Plamela ; Vrzy, Laura ; Ansotegui, Ignacio J. ; Guidos-Fogelbach, Guillermo ; Solé, Dirceu ; Boulet, Louis-Philippe ; Baiardini, Ilaria ; Santus, Pierachille ; Nunes, Carlos
Objective: The optimal use of drug combinations for the management of asthma is providing significant results. This has prompted Interasma (Global Asthma Association) to take a position on inhaled triple therapy in asthma.Methods: We performed an extensive literature research to clinical trials, meta-analyses, randomized controlled trials and systematic reviews.Results: Starting from an extensive literature review, Interasma executive committee discussed and approved this Manifesto, developed by Interasma scientific network (INES) members.Conclusions: The manifesto describes the evidence gathered to date and states, advocates, and proposes issues on inhaled corticosteroid (ICS) plus long-acting beta 2 agonist (LABA) and long-acting muscarinic antagonists (LAMA) with the aim of challenging assumptions, fostering commitment, and bringing about change.