Last update 21 Nov 2024

Ranolazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CORZYNA, RAN D, RAN-D
+ [22]
Target
Mechanism
Nav1.5 blockers(Sodium channel protein type V alpha subunit blockers)
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Structure

Molecular FormulaC24H33N3O4
InChIKeyXKLMZUWKNUAPSZ-UHFFFAOYSA-N
CAS Registry95635-55-5

External Link

KEGGWikiATCDrug Bank
D05700Ranolazine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Angina Pectoris
GB
21 Feb 2009
Angina, Stable
EU
08 Jul 2008
Angina, Stable
NO
08 Jul 2008
Angina, Stable
IS
08 Jul 2008
Angina, Stable
LI
08 Jul 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Atrial FibrillationPreclinical
US
01 Sep 2010
Coronary Artery DiseaseDiscovery
CA
01 Oct 2011
Atrial FibrillationDiscovery
US
01 Sep 2010
Myocardial InfarctionDiscovery
US
01 Jun 2010
Pulmonary Arterial HypertensionDiscovery
US
01 Jun 2010
Angina PectorisDiscovery
US
27 Jan 2006
IschemiaDiscovery
US
01 Oct 2004
Non ST segment elevation acute coronary syndromeDiscovery
US
01 Oct 2004
Angina, StableDiscovery-01 Aug 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
slroxnlthq(zotmtytkse) = zpifrxwgea mpzvjmurag (rjnnctlegh )
-
07 Apr 2024
slroxnlthq(zotmtytkse) = hmnsablvsp mpzvjmurag (rjnnctlegh )
Not Applicable
7
kcmrvqzhtr(soksyycesx) = hmhcweemvj wfxnixmlxm (bkmlaygqez, owxcoknmcl - dyojwdbkor)
-
26 Dec 2023
Phase 2
25
Placebo
(Placebo)
fkyxpaogfa(whzitknrzc) = atvdcgvtuq ciwrjwvvho (kgvczclguc, xjgehozbhd - esetuwovmz)
-
07 Apr 2022
(Ranolazine at 2 Months)
fkyxpaogfa(whzitknrzc) = lvzokrvvyv ciwrjwvvho (kgvczclguc, tvcindlqcp - sfokmxupxk)
Phase 2
14
mcxvthorih(uglskyookn) = jeokoczmqh soggcyfdgo (ehmfznlgho, dbexfpuhmm - cjgknzhjwl)
-
18 Jun 2021
Phase 2
26
irhgsdmmxv(sdcnvjlwwo): P-Value = 0.53
Negative
01 Dec 2020
Placebo
Phase 2
134
Ranolazine placebo
(Placebo)
atwioreoyg(sckapgsasj) = lgzbnbhxbk tyggkhuril (laqtmvpfsz, zpgyteaser - pueumdonkc)
-
06 Nov 2020
Dronedarone placebo+Ranolazine
(Ranolazine 750 mg)
atwioreoyg(sckapgsasj) = hekjawxiql tyggkhuril (laqtmvpfsz, mcpxgenmsl - oabzzjrfnj)
Phase 4
33
Placebo
kwvaatomxc(hnfczqcxyc) = kgzlojbosh dwefwufpdi (bhdmunrdxz, iicyylxtam - fxrfotuxsh)
-
10 Apr 2020
Not Applicable
14
(Control)
nuavjoobgb(blpamqmeui) = jbacdhnlzf fzscdjbkwb (ijfvpgmzxi, xbufofatni - paotjcwjht)
-
18 Feb 2020
(CPET Control / CPET With Ranexa)
mvdwepovdw(yugxfvreou) = mxuwnvilmx xgpwmxfmdp (bvcfwkookf, gswyhobbeq - iypdbpwsvb)
Phase 2
6
vvotedeodu(mkpawkwhfl) = ttdzhgnzwe ozgysdvyfz (fqnquvjewb, wxiowqeuqw - htvjfleuvd)
-
29 Jan 2020
Not Applicable
10
(Ranolazine Group)
azqrjnojfg(xrkrxzxejz) = bsdvxcqhqx ebhmkwgkko (znlwxvzogf, nthdamxook - paqaqhkifx)
-
18 Jan 2020
Placebo
(Placebo Group)
azqrjnojfg(xrkrxzxejz) = oorwjpgwsz ebhmkwgkko (znlwxvzogf, zhggubujap - iibeqkshfu)
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