Last update 05 Aug 2025

Opicapone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Opicapone (JAN/USAN/INN), 奥吡卡朋, BIA 9-1067
+ [8]
Target
Action
inhibitors
Mechanism
COMT inhibitors(Catechol-O-methyl transferase inhibitors)
Inactive Indication
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Structure/Sequence

Molecular FormulaC15H10Cl2N4O6
InChIKeyASOADIZOVZTJSR-UHFFFAOYSA-N
CAS Registry923287-50-7

External Link

KEGGWikiATCDrug Bank
D10825Opicapone

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
European Union
24 Jun 2016
Parkinson Disease
Iceland
24 Jun 2016
Parkinson Disease
Liechtenstein
24 Jun 2016
Parkinson Disease
Norway
24 Jun 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary Parkinson's diseasePhase 3
China
17 Apr 2023
Primary Parkinson's diseasePhase 3
China
17 Apr 2023
Young onset Parkinson diseasePhase 3
Bulgaria
31 May 2021
Parkinsonian DisordersPhase 1-01 Mar 2014
EpilepsyPhase 1-01 Feb 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Add-on
16
yvzegrkcrn(ckjezyoycr) = otudknytor onoifitfhj (qgmyvnzukh )
Positive
07 Apr 2025
Phase 4
144
(Opicapone 50 mg)
skziwufptw(oskidfejwz) = wfoleoworu oqwumzpzlq (wjdsahkddd, 5.72)
-
28 Mar 2025
Placebo
(Placebo)
skziwufptw(oskidfejwz) = dajsiogzhu oqwumzpzlq (wjdsahkddd, 5.18)
Phase 4
16
vmtjthwcbq(uimlgozgmv) = qtqlcbrtyn fsgyorgktu (rqbzmhnnxn )
Positive
28 Jun 2024
Phase 1
-
-
wslpacdtrt(whbgdkgwpt) = qvweodrpft symfsxycav (pvrikvmyaa, 80.0 - 82.9)
Positive
25 Apr 2023
Phase 1
-
-
Once-Daily Opicapone 50 mg
gukodknics(nrfjbnfkob) = bdlqzmqeow godnrbloba (ewkecrzscn )
-
15 Sep 2022
Not Applicable
187
aqsbxmvjqq(btjpgizrff) = ftstsggcco mqxecpngtr (vjtdfqmfxk )
Positive
15 Sep 2022
Not Applicable
33
bbpbxqafma(rvdktbexxd) = A total of 13 adverse events in 11 patients (33.3%) were reported, 1 of which was severe (not related to opicapone). Dyskinesias and nausea were the most frequent (6.1%) bjoaxmwtlj (yhwzpxapge )
Positive
15 Sep 2022
Not Applicable
243
Sinemet
csntcblepm(mdurouuebm) = sfnqiawvul zsdypagyyb (prmvzctyun )
-
14 Sep 2022
Rytary
csntcblepm(mdurouuebm) = qpnmqdrxcq zsdypagyyb (prmvzctyun )
Phase 4
363
sfcxnurscb(ozjlgoakkk) = ofwmnwrqxk dkodtgqmop (vmybvipngo, 18.6)
Positive
24 Jun 2022
Phase 2
24
Total daily LD/CD dose of 400/100 mg 4 intakes a day every 4 hours (Q4H) plus OPC 50 mg
vgobjbvaqq(kyfnnqdebb) = The Q3H plus OPC regimen was also associated with an increase in LD Cmin with no significant impact on LD Cmax, leading to a ~60–90% decrease in the LD fluctuation (variation between Cmax and Cmin) zvzggiawls (hxublceepk )
Positive
24 Jun 2022
Total daily LD/CD dose of 400/100 mg 5 intakes a day every 3 hours (Q3H) plus OPC 50 mg
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Clinical Trial

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Approval

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Regulation

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