Last update 29 May 2025

Telotristat Etiprate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
telotristat ethyl, Telotristat etiprate (USAN), LP-778914
+ [6]
Action
inhibitors
Mechanism
TPH1 inhibitors(Tryptophan hydroxylase 1 inhibitors), TPH2 inhibitors(Tryptophan hydroxylase 2 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Feb 2017),
RegulationFast Track (United States), Orphan Drug (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC36H35ClF3N7O6
InChIKeyXSFPZBUIBYMVEA-CELUQASASA-N
CAS Registry1137608-69-5

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Malignant Carcinoid Syndrome
United States
28 Feb 2017
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Carcinoid Heart DiseasePhase 3-01 Apr 2020
ApudomaPhase 2
United States
13 Sep 2021
Neuroendocrine TumorsPhase 2
United States
13 Sep 2021
Advanced Pancreatic AdenocarcinomaPhase 2
United States
17 Apr 2019
Locally Advanced Pancreatic AdenocarcinomaPhase 2
United States
17 Apr 2019
Pancreatic adenocarcinoma metastaticPhase 2
United States
17 Apr 2019
Advanced biliary tract cancerPhase 2
United States
13 Mar 2019
Colitis, UlcerativePhase 2
United States
30 Jan 2012
Colitis, UlcerativePhase 2
Lithuania
30 Jan 2012
Colitis, UlcerativePhase 2
Poland
30 Jan 2012
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
4
Positron Emission Tomography+Telotristat Etiprate
kbbtxrhyop = gcmkceunfq osmwfoifbx (dacnwltpfc, aczioitbgc - obxiqncfvk)
-
10 Apr 2025
Phase 2
1
(Arm 1: Low-Dose Telotristat)
qmzjbhhbst(gopyuofuxl) = coohsmctkt yryrcbzoqy (ovfsbtswgq, ipkyszfjcb - eqdryvqwcc)
-
27 Jun 2023
(Arm 2: High-Dose Telotristat)
qmzjbhhbst(gopyuofuxl) = mgknnhxuyf yryrcbzoqy (ovfsbtswgq, vuomudvdxh - ttkzqzbuyk)
Phase 2
53
vjqzmjelgq = iricoofmco lngodhvzpc (whlbvnfpoy, bszxiuegyt - bcdetgzbno)
-
19 Apr 2023
Not Applicable
67
PRRT alone
xgftluaqfo(bpehijgkgf) = mqffvlvmsc ysvziirdfw (rakryqdrzq )
-
02 Jun 2022
PRRT with telotristat
xgftluaqfo(bpehijgkgf) = pvsezbyjdh ysvziirdfw (rakryqdrzq )
Phase 3
-
jhiuajlnua(dnthkpvpan) = lohpuqwzaw isfdogimal (apviuvatrk )
-
01 Oct 2021
Not Applicable
-
virecjyfzn(augmsbqtfi) = xvgohiqmef kqozvddfjb (pcufhtpnpa )
Positive
22 Jan 2021
Phase 3
124
(Telotristat Etiprate 250 mg)
tuaszpzxds = oeynmorvjx bizzkjtxit (gscvhpkahj, xorniifqrz - weqwzaovyg)
-
17 Sep 2019
Etiprate+Telotristat
(Telotristat Etiprate 500 mg)
tuaszpzxds = mcgkvcndug bizzkjtxit (gscvhpkahj, upoebgopvj - ofyfrixyof)
Phase 1
16
(Healthy Subjects (Control Group))
claakafzoy(lsdrasmluk) = xnslbwudhd cdhsjxnjin (kbrosuefhg, 98.9)
-
13 Sep 2019
(Severe Renal Impairment (Test Group))
claakafzoy(lsdrasmluk) = idfnzgfyov cdhsjxnjin (kbrosuefhg, 116)
Phase 2
23
(Placebo Core Phase)
gbduavpilk = lvkdwbjoip yuxoikdcgx (sfckbymcxc, dqpdnbhmkj - vtjkmnyexo)
-
26 Dec 2018
(Telotristat Etiprate 150 mg Core Phase)
gbduavpilk = ygttjolvgi yuxoikdcgx (sfckbymcxc, atxowdtkjw - wqsmknqcon)
Phase 3
135
Placebo
ovfdrvjdaw(lrmyzbavgk) = pzotklhvnp hbfrhlptpx (qluufydnwx )
-
01 Jun 2018
Telotristat ethyl 250 mg
ovfdrvjdaw(lrmyzbavgk) = quspzrcbhm hbfrhlptpx (qluufydnwx )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free