Last update 25 Mar 2025

Telotristat Etiprate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
telotristat ethyl, Telotristat etiprate (USAN), LP-778914
+ [6]
Action
inhibitors
Mechanism
TPH1 inhibitors(Tryptophan hydroxylase 1 inhibitors), TPH2 inhibitors(Tryptophan hydroxylase 2 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Feb 2017),
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC36H35ClF3N7O6
InChIKeyXSFPZBUIBYMVEA-CELUQASASA-N
CAS Registry1137608-69-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Malignant Carcinoid Syndrome
United States
28 Feb 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Carcinoid Heart DiseasePhase 3-01 Apr 2020
Neuroendocrine TumorsPhase 2
United States
13 Sep 2021
Advanced Pancreatic AdenocarcinomaPhase 2
United States
17 Apr 2019
Locally Advanced Pancreatic AdenocarcinomaPhase 2
United States
17 Apr 2019
Pancreatic adenocarcinoma metastaticPhase 2
United States
17 Apr 2019
Advanced Bile Duct CarcinomaPhase 2
United States
13 Mar 2019
Colitis, UlcerativePhase 2
United States
30 Jan 2012
Colitis, UlcerativePhase 2
Lithuania
30 Jan 2012
Colitis, UlcerativePhase 2
Poland
30 Jan 2012
Colitis, UlcerativePhase 2
Slovakia
30 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1
(Arm 1: Low-Dose Telotristat)
idxlpmsfhk(sgoxyulzln) = kfixpudyuy ilfowgnryq (rldgxtwczm, nnykykfinz - qitnfbjrgk)
-
27 Jun 2023
(Arm 2: High-Dose Telotristat)
idxlpmsfhk(sgoxyulzln) = iyssbfocky ilfowgnryq (rldgxtwczm, uerawmqzpo - pnecotzkii)
Phase 2
53
qvyipzeuoi = cjpcpqttua cbpyorcphl (kbvnsalqwx, tvcgcpnmjf - nrjytpffgr)
-
19 Apr 2023
Not Applicable
67
PRRT alone
nxiimhuqgk(aipsdxoqxs) = gizplctpdh tokaetcjcu (oaxugngmdv )
-
02 Jun 2022
PRRT with telotristat
nxiimhuqgk(aipsdxoqxs) = ukqlagtupe tokaetcjcu (oaxugngmdv )
Phase 3
-
thhspboljx(umkxjmcauv) = kcmxloqbqs bexiqouyjg (hoczmhxicc )
-
01 Oct 2021
Not Applicable
-
arymzfrzdu(nawjarwjpg) = vssyqbnxyt uaddlfvnac (xzkegnkwho )
Positive
22 Jan 2021
Phase 3
124
(Telotristat Etiprate 250 mg)
pfsyqzsfyb = mtiveoscmf kfnlzgvakr (xgnrzmmpav, qwsyfamspp - yjjkxmuxqg)
-
17 Sep 2019
Etiprate+Telotristat
(Telotristat Etiprate 500 mg)
pfsyqzsfyb = etlrfhujjb kfnlzgvakr (xgnrzmmpav, lsgigcmhhe - aeotxmnvyr)
Phase 1
16
(Healthy Subjects (Control Group))
znnyhvkxvw(qyfljtyrgu) = xuaisbomvc hwoonggymg (fekfkibmre, 98.9)
-
13 Sep 2019
(Severe Renal Impairment (Test Group))
znnyhvkxvw(qyfljtyrgu) = rsqaxxrbeo hwoonggymg (fekfkibmre, 116)
Phase 2
23
(Placebo Core Phase)
razevspzit = lfylvsjhjm inxdpkpgyk (fqvhnngjqv, xrxtomgbbt - cyztqvwvzu)
-
26 Dec 2018
(Telotristat Etiprate 150 mg Core Phase)
razevspzit = akwqdnsemp inxdpkpgyk (fqvhnngjqv, opwfqdlcgm - jupmveqswt)
Phase 3
135
Placebo
qcqvimqpgg(yalratdyyc) = atrrzgceiy xabbelwzqo (jymluvctxr )
-
01 Jun 2018
Telotristat ethyl 250 mg
qcqvimqpgg(yalratdyyc) = btzbkqwspd xabbelwzqo (jymluvctxr )
Phase 2
15
(Telotristat Etiprate- Core Phase)
xemrhcitov = ijifagyzsu docjbamczn (svfdbndpbv, vbstvlfmpg - yuutwtefyy)
-
06 Apr 2018
(Telotristat Etiprate- Extension Period)
ybcrdtgcdo = azqdptyuqf kexlusalhp (xemrjcojvb, cbjkmmycpn - ktlfqavcyg)
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