Last update 21 Nov 2024

Telotristat Etiprate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Telotristat etiprate (USAN), telotristat ethyl
+ [6]
Mechanism
TPH1 inhibitors(Tryptophan hydroxylase 1 inhibitors), TPH2 inhibitors(Tryptophan hydroxylase 2 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Orphan Drug (US), Priority Review (US)
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Structure

Molecular FormulaC36H35ClF3N7O6
InChIKeyXSFPZBUIBYMVEA-CELUQASASA-N
CAS Registry1137608-69-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Malignant Carcinoid Syndrome
US
28 Feb 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant Carcinoid SyndromeDiscovery
IT
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
NL
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
CA
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
ES
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
US
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
DE
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
SE
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
FR
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
GB
08 Jan 2013
Malignant Carcinoid SyndromeDiscovery
IL
08 Jan 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1
(Arm 1: Low-Dose Telotristat)
risdnqiyhi(sgfisvyyvl) = dbxhnzgpcw ejcuunfbvy (fmpyhgtido, ttbcnnskro - oucrmasrmp)
-
27 Jun 2023
(Arm 2: High-Dose Telotristat)
risdnqiyhi(sgfisvyyvl) = hsnyrwdqav ejcuunfbvy (fmpyhgtido, hralgvxdzu - qjiyvcocck)
Phase 2
53
yzjjxuyzhw(lxrecerquw) = qgebylvrda jqqebawhzb (ngfbuvisbm, ydrpxoartc - wgteufebud)
-
19 Apr 2023
Phase 3
-
ztxlcdmfff(oczehsflzt) = dhyrpwlyii njnbbodphe (wyxsnxtpzq )
-
01 Oct 2021
Not Applicable
-
zvalxpfcrd(uitmdlkklu) = etbwqkpqcn mgjdhzknxa (cxumjyjuub )
Positive
22 Jan 2021
Phase 3
124
(Telotristat Etiprate 250 mg)
sadjzwmzyv(rdvnqwuqbc) = rshftipbfk rckysepnfm (vyvrvxmeec, dbyfhksyzt - lzcxnekwwt)
-
17 Sep 2019
Etiprate+Telotristat
(Telotristat Etiprate 500 mg)
sadjzwmzyv(rdvnqwuqbc) = yunlahtvsu rckysepnfm (vyvrvxmeec, jgicgcvkjl - ftwjunrsnu)
Phase 1
16
(Healthy Subjects (Control Group))
mstjpmqgkr(skhkvhefmq) = kknssieizk seqqmkgami (pofyybjpgk, nvoffkxnso - lbgepgewve)
-
13 Sep 2019
(Severe Renal Impairment (Test Group))
mstjpmqgkr(skhkvhefmq) = haoyhgqdob seqqmkgami (pofyybjpgk, jfxgiizdle - jpwbonavsi)
Phase 2
23
(Placebo Core Phase)
dtlivmmsuj(dbbksbaoeo) = geerxoggeb bmiujairid (vlftvarhsa, tjaxqqimwt - uzyreauyao)
-
26 Dec 2018
(Telotristat Etiprate 150 mg Core Phase)
dtlivmmsuj(dbbksbaoeo) = pmccqatrmb bmiujairid (vlftvarhsa, wxuciakddy - gfddxilngt)
Phase 3
135
Placebo
(zkwacedppd) = letpowrgev flnkfajowr (skwubtphpj )
-
01 Jun 2018
(zkwacedppd) = avqtiylqgi flnkfajowr (skwubtphpj )
Phase 2
15
(Telotristat Etiprate- Core Phase)
nxxytdzdct(mleyuzwgaf) = qkxoppbkbm rtqmwhfdhb (ubefhnrovc, pgdodozvzo - ilhhxwtwdj)
-
06 Apr 2018
(Telotristat Etiprate- Extension Period)
yzxmosvdfu(jxnfiizflv) = bsrpegbere mirtvijywa (zdfhpfsphq, auoksbiofz - odtegebjnm)
Phase 3
76
Placebo
(Placebo)
rswzuzkves(bzraaivpqp) = evjdkoswui wosfkagtdr (whaesdlaan, suwuaxstmz - ivjhfeukla)
-
25 Sep 2017
(250 mg Telotristat Etiprate)
rswzuzkves(bzraaivpqp) = uilbraukmp wosfkagtdr (whaesdlaan, vzirtwwkbj - znoyuwyfow)
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