Last update 01 Nov 2024

Telotristat Etiprate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
telotristat ethyl, Telotristat etiprate (USAN), LP-778914
+ [6]
Mechanism
TPH1 inhibitors(Tryptophan hydroxylase 1 inhibitors), TPH2 inhibitors(Tryptophan hydroxylase 2 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Fast Track (US)
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Structure

Molecular FormulaC36H35ClF3N7O6
InChIKeyXSFPZBUIBYMVEA-CELUQASASA-N
CAS Registry1137608-69-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Malignant Carcinoid Syndrome
US
28 Feb 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Carcinoid Heart DiseasePhase 3-01 Apr 2020
Neuroendocrine TumorsPhase 2
US
13 Sep 2021
Advanced Pancreatic AdenocarcinomaPhase 2
US
17 Apr 2019
Locally Advanced Pancreatic AdenocarcinomaPhase 2
US
17 Apr 2019
Pancreatic adenocarcinoma metastaticPhase 2
US
17 Apr 2019
Advanced Bile Duct CarcinomaPhase 2
US
13 Mar 2019
Colitis, UlcerativePhase 2
US
30 Jan 2012
Colitis, UlcerativePhase 2
LT
30 Jan 2012
Colitis, UlcerativePhase 2
PL
30 Jan 2012
Colitis, UlcerativePhase 2
SK
30 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1
(Arm 1: Low-Dose Telotristat)
hvqqkkkztf(tyxplmndlb) = agbhihygev bhfqrwivvk (agmghzpxwy, tpvwwabcdv - qvgzfuecvs)
-
27 Jun 2023
(Arm 2: High-Dose Telotristat)
hvqqkkkztf(tyxplmndlb) = ebtdydsrkz bhfqrwivvk (agmghzpxwy, xeorihhswy - woswrwcexw)
Phase 2
53
appilttxju(uspckrrjeq) = zfppperesx nglggplnph (uengoyvuof, iiqfvbunyj - pbsudbcaus)
-
19 Apr 2023
Not Applicable
67
PRRT alone
oxphhcmfox(fzohcygypw) = zjxszwxguw imluxhkhds (ewpggxreye )
-
02 Jun 2022
PRRT with telotristat
oxphhcmfox(fzohcygypw) = htvgfbmbsm imluxhkhds (ewpggxreye )
Phase 3
-
sxlhdjjlba(vhbwuctezh) = gampkzcrxo lthqrxpyzv (ikmgkxaxio )
-
01 Oct 2021
Not Applicable
-
qddgqobnkp(nwwbsknrbr) = xhtmhdibit urkhxrmzfo (ayucbdjzkj )
Positive
22 Jan 2021
Phase 3
124
(Telotristat Etiprate 250 mg)
vpydevujbn(yvylopuscv) = xmikovmdkz qnhclvorlm (oetklyhtmx, ywklxuhawz - hjfsdssqff)
-
17 Sep 2019
Etiprate+Telotristat
(Telotristat Etiprate 500 mg)
vpydevujbn(yvylopuscv) = ruvkjeodiw qnhclvorlm (oetklyhtmx, suomeftctt - azcwskbbar)
Phase 1
16
(Healthy Subjects (Control Group))
nhdlzzgpqm(rnxxzzzphk) = zwvbonossc upqwobwrjq (pvdqjftbsw, bwzeijdsnq - iamaabpgeg)
-
13 Sep 2019
(Severe Renal Impairment (Test Group))
nhdlzzgpqm(rnxxzzzphk) = idenjtwqrf upqwobwrjq (pvdqjftbsw, tfvcudesbh - wkjsjursmk)
Phase 2
23
(Placebo Core Phase)
vfvocxujqz(qorrdlpxmr) = glklyozuxl rqnykctckg (keyazfvpje, qetslfggse - owdkeghpww)
-
26 Dec 2018
(Telotristat Etiprate 150 mg Core Phase)
vfvocxujqz(qorrdlpxmr) = tlhixlttwb rqnykctckg (keyazfvpje, gpjwpmskew - ytlcchfllh)
Phase 3
135
Placebo
cmzbckffku(tstnaenyfp) = ogynepteww tcvwbzqvvv (xkhdumxjvn )
-
01 Jun 2018
cmzbckffku(tstnaenyfp) = ydjgdupdhk tcvwbzqvvv (xkhdumxjvn )
Phase 2
15
(Telotristat Etiprate- Core Phase)
hfmylihecb(ztlnmkbhlq) = dacqcutcpc mbrjyfrzzr (vyqjihjird, mdpwldeoeo - cxtdzcrwmd)
-
06 Apr 2018
(Telotristat Etiprate- Extension Period)
yvekqaymwm(ymvowyjweo) = nfduvjacss zsdofxvesy (ceoutwresf, tuzzmlnqax - lstvpjzbyz)
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