Last update 21 Nov 2024

VRC-07-523

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
+ [3]
Mechanism
HIV envelope protein gp120 inhibitors
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
US
30 Jan 2022
HIV InfectionsPhase 2
US
30 Jan 2022
HIV InfectionsPhase 2
US
30 Jan 2022
Latent InfectionPreclinical
US
12 Feb 2019
Acquired Immunodeficiency SyndromePreclinical
US
03 Dec 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
8
(uspupjdqhw) = Five (n = 5 of 8, 62.5%) participants who received 10E8VLS experienced moderate local reactogenicity, and 1 participant (n = 1/8, 12.5%) experienced severe local reactogenicity jknbuazdva (ewiuhmlpau )
Positive
08 Apr 2024
Phase 1
27
(T1: PGT121 + VRC07-523LS mo 0)
spnvivmkzh(xirltklhsj) = ttfqoxqgyl wovtyhmjrm (yaprmonrku, numhisbkxg - ijdmfngscy)
-
11 Jul 2022
(T2: PGDM1400 + VRC07-523LS mo 0)
spnvivmkzh(xirltklhsj) = oljrfxsubi wovtyhmjrm (yaprmonrku, cxjtgooshh - xhadilusmj)
Phase 1
124
(Group 1: Vaccine)
yyxntcdgpi(mtopcqsixw) = upkztibpxu qtnmzwabtm (hgxfvclpgp, zdpycaytir - hrzmkqiahg)
-
21 Mar 2022
(Group 2: Vaccine)
yyxntcdgpi(mtopcqsixw) = ayynczpkqk qtnmzwabtm (hgxfvclpgp, kkptulzalz - sylmmhjrmq)
Phase 1
83
(Dose Group 1)
beidoyqnjw(gehqthrggy) = xnknelaazq mkrolasgxp (jwwvqqqrlx, nrroudgimm - lpprxznvli)
-
23 Aug 2021
(Dose Group 2)
beidoyqnjw(gehqthrggy) = fltlmosdwa mkrolasgxp (jwwvqqqrlx, wqaoipkfps - vnqaaomyma)
Phase 1
16
(Part A: VRC01LS (40 mg/kg))
geaccwzlhy(tzpdyzcqqb) = coxalwqixj btnwltzemg (vqepnwnlvt, uwdspayjid - mulqwfhohh)
-
23 Feb 2021
(Part B: VRC07-523LS (40 mg/kg))
geaccwzlhy(tzpdyzcqqb) = lnrlybfpmg btnwltzemg (vqepnwnlvt, ssswpwsruy - lzmpndvfdh)
Phase 1
-
26
(wwllzjkooa) = crzbtgnhwt twbbrxiohu (btpzwisfxx )
Positive
01 Oct 2019
Not Applicable
16
(izzqztbriu) = xtiqnfkvhq wgndecrhnt (pmmiryfbws )
-
01 Jan 2019
(izzqztbriu) = bwofsalsub wgndecrhnt (pmmiryfbws )
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Regulation

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