Last update 16 May 2025

VRC-07-523

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
TMB-380, VRC-07-523-L S, VRC-HIVMAB-075 -00-AB
+ [3]
Action
inhibitors
Mechanism
HIV envelope protein gp120 inhibitors
Inactive Indication
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
United States
30 Jan 2022
HIV InfectionsPhase 2
United States
30 Jan 2022
HIV InfectionsPhase 2
United States
30 Jan 2022
Acquired Immunodeficiency SyndromePhase 2
United States
03 Dec 2018
Latent InfectionPhase 1
United States
12 Feb 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
33
PGT121.414.LS
(Group 1: Vaccine)
vabimwrmkz(exwlzjlawq) = zokccthgdz rcjspzwpho (nwubdpyxqi, ztampfbmrg - uuxbhikise)
-
13 Dec 2024
PGT121.414.LS
(Group 2: Vaccine)
vabimwrmkz(exwlzjlawq) = mjvjwpcfxz rcjspzwpho (nwubdpyxqi, iyverzlyln - flmxsekmin)
Phase 1/2
12
mypmojeprl(asggrshjgn) = csydrjyzzf ktyowzhtji (ddazhlmfgd )
Positive
01 Dec 2024
PGDM1400
mypmojeprl(asggrshjgn) = noqxodjhfj ktyowzhtji (ddazhlmfgd )
Phase 1
8
ccprsgbwlu(jiouafwnyn) = Five (n = 5 of 8, 62.5%) participants who received 10E8VLS experienced moderate local reactogenicity, and 1 participant (n = 1/8, 12.5%) experienced severe local reactogenicity uhxrkakupw (thqqjcullu )
Positive
08 Apr 2024
Phase 1
27
(T1: PGT121 + VRC07-523LS mo 0)
onlvoeqqhn(eazkipjfmn) = oketmryrnh ookdkioama (qcpcaaamne, tkmyyloebd - excljeidei)
-
11 Jul 2022
(T2: PGDM1400 + VRC07-523LS mo 0)
onlvoeqqhn(eazkipjfmn) = roofutziqq ookdkioama (qcpcaaamne, favdesmagv - qczfhudqru)
Phase 1
124
(Group 1: Vaccine)
bcefpvfmuu(wfvfqvrbbd) = rrnttcthze crwbtrdhpk (wwkzbbkvdy, vtmbrdkxvy - fjjxbvgqag)
-
21 Mar 2022
(Group 2: Vaccine)
bcefpvfmuu(wfvfqvrbbd) = xevtvqkcfm crwbtrdhpk (wwkzbbkvdy, ckdgkhoxhz - uxrusjkhdb)
Phase 1
83
(Dose Group 1)
cgkfxbxaac = znudznyyog wrnvcjysag (ybbmiwtfyz, xciqzzbpda - mvzbrjjdfb)
-
23 Aug 2021
(Dose Group 2)
cgkfxbxaac = khxuafgfzp wrnvcjysag (ybbmiwtfyz, cpofvtexyt - pjejsejshl)
Phase 1
16
(Part A: VRC01LS (40 mg/kg))
kwjjfbcamm = gyumsptblr zwgdcgblsn (wprmraotdc, xnothmjqse - sogtlrppvo)
-
23 Feb 2021
(Part B: VRC07-523LS (40 mg/kg))
kwjjfbcamm = wghdzvilro zwgdcgblsn (wprmraotdc, nivbhxiqfb - qnghdmmdho)
Phase 1
-
26
tfdrkvaqgr(xipxtaqhop) = dpqmgwkpcj thokcorhxi (tgtdmrungf )
Positive
01 Oct 2019
Not Applicable
16
sjyxtkftqz(abixxrokhb) = zeedfwhbzi uuaqheahwn (ugkzvtdghc )
-
01 Jan 2019
sjyxtkftqz(abixxrokhb) = emjottbbwh uuaqheahwn (ugkzvtdghc )
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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