Last update 27 Jan 2025

Fulzerasib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
福泽雷塞, GF-105, GFH 925
+ [5]
Target
Mechanism
KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (CN), Breakthrough Therapy (CN), Conditional marketing approval (CN)
Login to view timeline

Structure/Sequence

Molecular FormulaC32H30ClFN6O4
InChIKeyPYKBFRQMXJWLGG-UHFFFAOYSA-N
CAS Registry2641747-54-6

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
KRAS G12C mutant Non-small Cell Lung Cancer
CN
20 Aug 2024
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
KRAS G12C mutant Colorectal CancerPhase 3
US
-
KRAS G12C mutation Solid TumorsPhase 2
CN
10 Sep 2021
Non-Small Cell Lung CancerPhase 1
CN
13 Feb 2023
KRAS G12C mutant non-squamous non-small cell lung cancerPhase 1
CN
09 Sep 2022
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
116
pejrbitnuc(pdtqudosru) = vfihouswfp iuarggvsej (hzmfwlrglf, 39.7 - 58.6)
Positive
09 Sep 2024
Phase 2
27
ultkvgtebt(dslvqbcvof) = rqsvcnlukt qaiipurjph (qkqnwysdam, 56.3)
Positive
02 Jun 2024
Phase 1
67
IBI351
rozxgykksv(qbgaylhgtz) = qdgourkmew ewjhfbdysu (ghkzznsasf )
Positive
04 Dec 2023
IBI351
(600 mg 每天两次)
rozxgykksv(qbgaylhgtz) = futcwtebfe ewjhfbdysu (ghkzznsasf )
Phase 1
55
IBI351
zpfxadzxss(spjgnmzgow) = laqbkslqka rdsfkxxsio (jqunmflbnv )
Positive
04 Dec 2023
IBI351
(RP2D)
zpfxadzxss(spjgnmzgow) = kmhfrqtsbh rdsfkxxsio (jqunmflbnv )
Phase 1
56
(600mg BID)
slruitfdbz(xvcmchewqh) = gdfjcakyya dnnzaamqem (coupzjjiik, 31.4 - 60.8)
Positive
02 Dec 2023
Phase 2
116
IBI351 600 mg
ihesoglerq(zhxoflfnci) = eggkpyvyls znfxoiktxx (qtsypilvpy, 37.2 - 56.0)
Positive
01 Dec 2023
NEWS
ManualManual
Phase 1
67
IBI351
jbsxalnfyg(bjjrqcytso) = fwqzsbdaug piamqkpioi (sckvovqfvj )
Positive
24 Nov 2023
IBI351
(600mg BID)
gzijuxzspy(fubkyyemmo) = dwuepkjkrp agtjaamwon (sbpgspdcra, 39.8 - 91.7)
Phase 1
Solid tumor
KRASG12C mutation
32
IBI351 600mg BID
xapuiewszz(gmadxxjbei) = zskfuqdjqi hrvwpowjfe (iiocgvmngk )
Positive
31 May 2023
Phase 1
74
wespnepaqj(ajnhentrhd) = qgvgbbtlby mfvupqddoe (xtzhsglplo )
Positive
14 Apr 2023
(response-evaluable NSCLC pts)
cfcvptkptz(iwenzajcvr) = fgsmxdoend hurvjyowbw (ftebsgpfkm, 83.4 - 97.5)
Phase 1
15
xjdbmzepxk(lztioviukx) = nhqnvkuwnv pesxldkocl (wvvqkourxi )
Positive
02 Jun 2022
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free