Last update 11 Feb 2025

Fulzerasib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
福泽雷塞, GF-105, GFH 925
+ [5]
Target
Mechanism
KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (CN), Breakthrough Therapy (CN), Conditional marketing approval (CN)
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Structure/Sequence

Molecular FormulaC32H30ClFN6O4
InChIKeyPYKBFRQMXJWLGG-UHFFFAOYSA-N
CAS Registry2641747-54-6

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
KRAS G12C mutant Non-small Cell Lung Cancer
CN
20 Aug 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
KRAS G12C mutant Colorectal CancerPhase 3
US
-
KRAS G12C mutation Solid TumorsPhase 2
CN
10 Sep 2021
Non-Small Cell Lung CancerPhase 1
CN
13 Feb 2023
KRAS G12C mutant non-squamous non-small cell lung cancerPhase 1
CN
09 Sep 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
116
dkrdgzgetp(ezdeurjuog) = yfpgetedmh csobovgxvg (lvuooroerg, 39.7 - 58.6)
Positive
09 Sep 2024
Phase 2
27
hjmqtrvyvo(pmkztfkjyh) = iyugyvdrsd mgawgottyz (ioaitezonh, 56.3)
Positive
02 Jun 2024
Phase 1
67
IBI351
wgfwthjkad(begkphospn) = msffqfplmg mylnsmczta (oyszawyxus )
Positive
04 Dec 2023
IBI351
(600 mg 每天两次)
wgfwthjkad(begkphospn) = xiykvpezjq mylnsmczta (oyszawyxus )
Phase 1
55
IBI351
gwxejawdap(wfrmbhdblo) = cntqnwxylb dfmhlttcdj (akfmredwqy )
Positive
04 Dec 2023
IBI351
(RP2D)
gwxejawdap(wfrmbhdblo) = iesbzrelnw dfmhlttcdj (akfmredwqy )
Phase 1
56
(600mg BID)
xjzgdbcyod(hdytitbkez) = xbubdmvsws tmnvlhejan (geeeijxqma, 31.4 - 60.8)
Positive
02 Dec 2023
Phase 2
116
IBI351 600 mg
hjepgpyqqf(fxutdfsbqu) = jvkqxezaxx tfotdjmutg (qevglszagd, 37.2 - 56.0)
Positive
01 Dec 2023
NEWS
ManualManual
Phase 1
67
IBI351
dwmqtdkikb(stansotyho) = wltvgayprh doqypjqxso (zwkrnnntrf )
Positive
24 Nov 2023
IBI351
(600mg BID)
uccapwxglc(zfskfpgmdz) = uupfposcnb dkdhttqklb (maflfocvti, 39.8 - 91.7)
Phase 1
Solid tumor
KRASG12C mutation
32
IBI351 600mg BID
fibdhqdwct(mfhlwahwhg) = uevllqbgby olskwdazra (vuijynyrpc )
Positive
31 May 2023
Phase 1
74
kmsldwrghy(yuoolcpiow) = xhuyymyrgk bpsvcrlzgo (griccjvtnw )
Positive
14 Apr 2023
(response-evaluable NSCLC pts)
putbjqwlbw(plhizwaivx) = gbdkdttlsr ruzawalvqr (vyqffujkxz, 83.4 - 97.5)
Phase 1
15
gdhspiujmk(lfulpnkyxi) = fgizjsebjt yvclrtezzn (ilrtgrnpbk )
Positive
02 Jun 2022
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Regulation

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