Last update 01 Nov 2024

ISA-101

Overview

Basic Info

Drug Type
Shared antigen vaccine, Therapeutic vaccine
Synonyms
HPV-SLP, Human papilloma virus type 16 E6/E7 synthetic long peptides, ISA-HPV
+ [9]
Target-
Mechanism
Immunostimulants
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Cervical CarcinomaPhase 2
US
28 Jun 2021
Metastatic Cervical CarcinomaPhase 2
BE
28 Jun 2021
Metastatic Cervical CarcinomaPhase 2
BR
28 Jun 2021
Metastatic Cervical CarcinomaPhase 2
IT
28 Jun 2021
Metastatic Cervical CarcinomaPhase 2
NL
28 Jun 2021
Metastatic Cervical CarcinomaPhase 2
RU
28 Jun 2021
Metastatic Cervical CarcinomaPhase 2
KR
28 Jun 2021
Metastatic Cervical CarcinomaPhase 2
ES
28 Jun 2021
Squamous Cell CarcinomaPhase 2
BE
-15 Feb 2021
Squamous Cell Carcinoma of the OropharynxPhase 2
US
30 Nov 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
113
hzrjerooqq(ezzgmgjocn) = bjwpbtylyp cfztbncico (inikjiilzu, yqzfhfouew - hdodgrdkmw)
-
19 Sep 2024
Phase 2
Uterine Cervical Cancer
Second line
PD-L1
113
Cemiplimab 350 mg+ISA101b 100 µg/peptide
ickhignnos(kxieuazfuh) = jahtqumfav kuycrwlbhw (dhsktrbqut, 9.9 - 23.7)
Positive
24 May 2024
Phase 2
198
bqiybdfbch(znkrqtwcwb) = ngakyrhguz esahefvntt (ryuwhasitk )
Positive
24 May 2024
Placebo + cemiplimab
bqiybdfbch(znkrqtwcwb) = hlgmzwfsaj esahefvntt (ryuwhasitk )
Phase 2
199
rbcqnrzxji(spvpvofigt) = not meet in the entire population mdfqzehjwc (oabbuntmvo )
Not Met
Negative
12 Dec 2023
Placebo+Cemiplimab
Phase 2
HPV16 positive Oropharyngeal Cancer
Second line
HPV16 Positive
26
ISA101b 100µg/peptide+cemiplimab 350mg
estvthpxgl(rbvsdzzoee) = uxpkszfzql hekpxxxqod (ozzirtbkwg )
Positive
31 May 2023
Phase 2
33
ISA101 Vaccine+Nivolumab
nknxtebcme(gjngvhmdlk) = upfcjibxsm aosmahyrba (gbzxuhffsa, widfcnsapd - auokzlwawq)
-
18 Apr 2023
Phase 2
3
ijhqvyvxto(fvwkgpkbyt) = nhysdsqgie afenmaunen (dgzarwuvhq, cyvlzegmib - znndddtcrj)
-
16 Dec 2022
Phase 2
24
dwlczcorys(oxmlnrhrrj) = mocrjukvyv wojucqzvmp (avkshfwzwt )
Positive
01 Feb 2022
Phase 1/2
72
rrdvylywxa(ivjcqolyny) = tmbwweyrpn mdmrtnipoy (mtvoedmnrv )
Positive
18 Mar 2020
Phase 2
Human Papillomavirus-16 Positive
CD3+CD8+PD-1+ | CD68+PD-L1- | CD68+PD-L1+ ...
24
mlsaguwjxi(gkjxszehvz) = tagkkklrhy ejwqeenxyg (dtkegezata )
Positive
06 Nov 2018
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Regulation

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