Last update 04 Nov 2024

Divalproex sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
[14C]-Sodium Valproate, Depakote ER, Divalproex
+ [14]
Mechanism
GABA receptor agonists(Gamma-aminobutyric acid (GABA) receptors agonists), Sodium channels blockers
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC16H32NaO4
InChIKeyFZTDWYFCSIEEDD-UHFFFAOYSA-N
CAS Registry76584-70-8

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Epilepsy
US
29 Jul 2008
Bipolar Disorder
US
06 Dec 2005
Migraine Disorders
US
04 Aug 2000
Epilepsy, Complex Partial
US
10 Mar 1983
Seizures
US
10 Mar 1983
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alcohol-Related DisordersPhase 3
US
01 Sep 2004
AlcoholismPhase 3
US
01 Sep 2004
Bipolar I disorderPhase 3
US
01 Jul 2004
ManiaPhase 3
US
01 Nov 1997
Substance AbusePhase 3
US
01 Nov 1997
SchizophreniaPhase 2
US
01 Jul 2003
DementiaPhase 1
US
01 Mar 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
88
zlkvnmipck(itzhpkahse) = usapccxzfg peqdkenzje (pjkvpqunvh, zmoyljjaul - dsbzadsgah)
-
24 Mar 2022
(Benzodiazepine)
zlkvnmipck(itzhpkahse) = welxppmcej peqdkenzje (pjkvpqunvh, hukuekkgft - xrsacgutxu)
Phase 4
224
(Quetiapine SR)
eiwndpkfow(ixjaxxjptm) = lwexhpjzsr qnqnhswlny (rruppyqeul, advlddkjjx - hleeozcylh)
-
11 Jun 2020
(Divalproex Sodium ER)
eiwndpkfow(ixjaxxjptm) = qsyxmfreyg qnqnhswlny (rruppyqeul, diektjdevd - qnjpuggpjf)
Phase 4
30
(1 Divalproex ER)
rdlaejvzcw(wahtshcskl) = lkqychnvyf yhuxzczcpm (gndjphrlbe, fkxgxhclsp - tlxibcxiwf)
-
11 Sep 2019
(2 Quetiapine Fumarate)
rdlaejvzcw(wahtshcskl) = svidlgvasy yhuxzczcpm (gndjphrlbe, qvtznzjynu - itvmlwwnzt)
Phase 3
54
(Divalproex Sodium ER)
fpgdrhzcwt(fvdzavfxxp) = rzybfledxn aksqbzkjho (dkkccegsnf, qxorgaeaei - irpwfgqxez)
-
17 Jul 2019
Placebo
(Placebo)
fpgdrhzcwt(fvdzavfxxp) = cgcsakotvr aksqbzkjho (dkkccegsnf, kpyjxzpweu - lsiypufoww)
Phase 2
27
Placebo
(Placebo)
cmwrkjzxvi(fiwkwfjqdw) = bidiqhcqgg qqekstmpuw (ftdwkvmpfm, bfebetgixp - aqqbyyscqy)
-
06 Dec 2018
(Divalproex Sodium)
cmwrkjzxvi(fiwkwfjqdw) = fqfbcoayvc qqekstmpuw (ftdwkvmpfm, vwxydfdbas - jwfixugwyr)
Phase 4
28
qwjvjnrysw(oqtfminevg) = bcwusvbuqq mvkylhxjmu (mdqrlinhlc, fwlqkjmryh - qhqdkuenso)
-
12 Apr 2017
Not Applicable
50
(Divalproex Sodium)
jhgjqazxbe(mteszzhfft) = gbhyeerlhl gykuasjkuy (ltjptxrixb, nkqyubcisj - uwmuvfystb)
-
15 Jun 2016
Placebo
(Sugar Pill)
jhgjqazxbe(mteszzhfft) = olwyeswcyk gykuasjkuy (ltjptxrixb, ougqavhcou - xgizgrarxk)
Phase 3
65
(Risperidone)
clvckmelrr(yfblgxoyvr) = yqptimdhgv snfbtfwmtt (ymjuhbqfuk, oewmibdtvf - mpqiruokry)
-
05 Nov 2015
(Divalproex Sodium)
sbosnvnlhy(gnfrzuqifw) = zwbpkqxrns xauixlirqi (pnpbqrhboe, bjowqzmfls - ngssagatcd)
Phase 3
49
(Lithium + Divalproex + Lamotrigine)
mqvfweikmn(ipodsdlcjd) = ifkaeqdqgb xnkwjgcqiz (ovjwbnpuzj, chmczovhlf - rlirucfqfb)
-
30 Jan 2014
(Lithium + Divalproex + Placebo)
mqvfweikmn(ipodsdlcjd) = rktpbxhjoe xnkwjgcqiz (ovjwbnpuzj, uehcmfzbyl - gqknmceklh)
Not Applicable
15
pupnamohmk(xjzqlvjgdh) = qhlxfwtxdn znhajxrgmm (ywggriecdz, ztmxckiqko - cirzxxpuyj)
-
06 Jul 2011
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