Last update 13 Dec 2025

LNP-7457

Overview

Basic Info

Drug Type
Chemical drugs
Synonyms
PRMT5 inhibitor(Lupin)
Target
PRMT5
Action
inhibitors
Mechanism
PRMT5 inhibitors(Protein arginine methyltransferase 5 inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Metastatic Solid Tumor
Inactive Indication
Hematologic Neoplasms
Originator Organization
Lupin LtdLupin Ltd
Active Organization
Lupin LtdLupin Ltd
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with LNP-7457
CTRI/2023/07/054753
/ RecruitingPhase 1
A Phase 1 Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LNP7457 in Subjects with Advanced or Metastatic Solid Tumors & Non-Hodgkins Lymphoma. - NIL
100 Clinical Results associated with LNP-7457
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100 Translational Medicine associated with LNP-7457
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100 Patents (Medical) associated with LNP-7457
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100 Deals associated with LNP-7457
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Solid TumorPhase 1-
Lupin LtdLupin Ltd
23 Apr 2025
NeoplasmsIND Application
India
Lupin LtdLupin Ltd
12 Jan 2022
Hematologic NeoplasmsPreclinical
India
Lupin LtdLupin Ltd
01 Feb 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
CTRI/2023/07/054753 (ASCO2025)
Phase 1
Metastatic Solid Tumor
17
pbwwikmqju(yurydfrdxi) = 47.1% djdlemzatd (yfzfgwrcpj )
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Positive
30 May 2025
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Clinical Trial

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Approval

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Regulation

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