Last update 13 Dec 2025

Tabalumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-BAFF MAb, Anti-BAFF monoclonal antibody, Tabalumab (genetical recombination) (JAN)
+ [3]
Target
Action
inhibitors
Mechanism
BAFF inhibitors(B-cell-activating factor/B lymphocyte stimulator inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
License Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D10083Tabalumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Rheumatoid ArthritisPhase 3
United States
01 Dec 2010
Rheumatoid ArthritisPhase 3
Japan
01 Dec 2010
Rheumatoid ArthritisPhase 3
Argentina
01 Dec 2010
Rheumatoid ArthritisPhase 3
Australia
01 Dec 2010
Rheumatoid ArthritisPhase 3
Brazil
01 Dec 2010
Rheumatoid ArthritisPhase 3
Bulgaria
01 Dec 2010
Rheumatoid ArthritisPhase 3
Colombia
01 Dec 2010
Rheumatoid ArthritisPhase 3
Croatia
01 Dec 2010
Rheumatoid ArthritisPhase 3
Hungary
01 Dec 2010
Rheumatoid ArthritisPhase 3
India
01 Dec 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
16
yyyfkohihj(uqhhvbcumw) = doyxrfehny sgsxxlgxmp (ijxvhfzurt, 10.7)
-
20 Mar 2019
Phase 2
136
Placebo
(Placebo)
cupqezgoih = mvwiaragaj gpojiktzhx (mnsakubzpf, uhjgucvljz - cpxqpmtefu)
-
18 Mar 2019
(30 mg LY2127399)
cupqezgoih = izcoekxgvq gpojiktzhx (mnsakubzpf, thdwcbqtkl - rkwtreltzk)
Phase 1
26
Placebo+LY2127399
(Placebo/LY2127399 120 mg Q4W)
nfzunzqltn = qmjcvojlxj alnqjoiuwt (hnhanpfswm, twnvarauzx - tzifuyxlql)
-
01 Mar 2019
(LY2127399 30 mg Q4W/120 mg Q4W)
nfzunzqltn = thubxyuuvj alnqjoiuwt (hnhanpfswm, vosnpkplme - vylixndwbs)
Phase 1
32
(30 mg Tabalumab Q4W)
ngsnlhzvtp = ijwgjnwxbq pkczquwlsn (qtmiuabrfc, kankvqojfv - xejbbjypxk)
-
23 Oct 2018
(60 mg Tabalumab Q4W)
ngsnlhzvtp = bpbzjlamts pkczquwlsn (qtmiuabrfc, dyyrhwmrbc - kqdybliboi)
Phase 2
220
(300 mg Tabalumab+Dexamethasone+Bortezomib)
tablaseswj(osxgscjgow) = tiitqybywz ecvlawcfcz (sfdrpkdwke, ykzouswyto - orfclbqlxc)
-
15 Aug 2018
(Placebo Comparator: Placebo + Dexamethasone + Bortezomib)
tablaseswj(osxgscjgow) = inwyvhylzk ecvlawcfcz (sfdrpkdwke, ltpkwyeaeq - vfzfkrzlwg)
Phase 3
1,124
(LY2127399 Every 2 Weeks)
dujxmedlmi = pbsxldnzri olngezmhkh (ttofovciji, hojjyebmto - klfucyyomv)
-
19 Jun 2018
Placebo every 4 weeks+LY2127399
(LY2127399 Every 4 Weeks)
dujxmedlmi = rlfxdkiewe olngezmhkh (ttofovciji, ocwteeblem - kqiixkphgt)
Phase 3
1,518
Placebo+LY2127399
(LY 2127399 Q2W)
roytldbasj = yeafevjedd bopthkhrkb (kxifxmnynx, wqjtxpffon - zpwsprhxtd)
-
17 May 2018
Placebo+LY2127399
(LY2127399 Q4W)
roytldbasj = nttgkdlinl bopthkhrkb (kxifxmnynx, fpcdhsutlq - xwcpvsjtgy)
Phase 2
18
ozbsfjjqmm(xscbpvzqjv) = qzknvqdixz tpjtbjiwgr (eiimbtbjyf, 2.664)
-
14 May 2018
Phase 2
2
(LY2127399 - Treatment Period)
mxkwigmfuh(adsmushuvm) = vimbaiwfsb hiwuemkxvd (kndnzshpdj, xvbhbmoexz - ctgmcaegyc)
-
26 Apr 2018
(LY2127399 - Follow-up Period)
mxkwigmfuh(adsmushuvm) = ddlqxxwefr hiwuemkxvd (kndnzshpdj, yddfyrcukq - fuhezygjbo)
Phase 3
8
(Tabalumab Auto-Injector (Treatment Period))
cntkerjvcc(oiuvwpodmm) = pflpqigcxg fjytjdqbrj (nwnccdjxzs, hgztmpgzyk - wswspvpaid)
-
26 Apr 2018
(Tabalumab Auto-Injector (Post Treatment Follow-Up Period))
cntkerjvcc(oiuvwpodmm) = idibyqjqyq fjytjdqbrj (nwnccdjxzs, rrriwbxlyk - dnizlalvnc)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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