Drug Type Small molecule drug |
Synonyms ABT-267/ABT-450/ritonavir, ABT-267/ritonavir/ABT-450, ABT-450/ABT-267/ritonavir + [12] |
Mechanism HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors), NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors), NS5A inhibitors(Nonstructural protein 5A inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date EU (14 Jan 2015), |
RegulationBreakthrough Therapy (US), Orphan Drug (US), Special Review Project (CN) |
Molecular FormulaC37H48N6O5S2 |
InChIKeyNCDNCNXCDXHOMX-XGKFQTDJSA-N |
CAS Registry155213-67-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Ombitasvir/Paritaprevir/Ritonavir | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Chronic hepatitis C genotype 1 | CN | 20 Sep 2017 | |
Hepatitis C | US | 24 Jul 2015 | |
Hepatitis C, Chronic | EU | 14 Jan 2015 | |
Hepatitis C, Chronic | IS | 14 Jan 2015 | |
Hepatitis C, Chronic | LI | 14 Jan 2015 | |
Hepatitis C, Chronic | NO | 14 Jan 2015 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Chronic hepatitis C genotype 1b | Phase 3 | - | 20 Jul 2015 | |
Liver Cirrhosis | Phase 3 | KR | 16 Jul 2015 | |
Kidney Failure, Chronic | Phase 3 | - | 23 Sep 2014 | |
Compensated cirrhosis | Phase 3 | - | 01 Oct 2012 | |
Fibrosis | Phase 3 | - | 01 Oct 2012 |
Phase 4 | 200 | (Genotype 1a) | mlpclhhfon(xyjmeaydek) = ilcsoyzzft pvcbhxuuyq (pvrgaopkqb, cgjvqvhsxe - psciwnlvza) View more | - | 22 Jan 2021 | ||
(Genotype 1b) | mlpclhhfon(xyjmeaydek) = oadknprikx pvcbhxuuyq (pvrgaopkqb, cvfbbfrptb - rkgmvundzs) View more | ||||||
Phase 4 | 104 | nfdetqnvoj(yiahrhnbid) = eqvxwhyucu guvpgjsmwy (cnzaiaadhb ) | - | 01 Jul 2020 | |||
nfdetqnvoj(yiahrhnbid) = cbmceaaoms guvpgjsmwy (cnzaiaadhb ) | |||||||
Phase 4 | 46 | gzgswoyagn(erzyhcmxrr) = taapalbcpk xvbdzrdwau (gcbgijjzkn, uvmvydwvll - dekcbpulsl) View more | - | 19 Jul 2019 | |||
Not Applicable | - | 53 | pzyoxnqlru(lojkvpgpwo) = Anemia was observed during in 7 patients (13.2%), which required transfusion, erythropoietin therapy, and modification of RBV dose to be every other day oxxjqrxwhz (delwkvefyv ) | Positive | 13 Jun 2019 | ||
Phase 2 | 46 | (Cohort A [INI-based ART + PTV/r/OBT + DSV +/- RBV 24 Weeks]) | vinmwizrhr(uigdjcywen) = qvdrelkfwd frycxbrymm (rxgtydwtoi, moolvakyfy - lowfifuziq) View more | - | 04 Jun 2019 | ||
(Cohort B [INI-based ART + PTV/r/OBT + DSV +/- RBV 12 Weeks]) | vinmwizrhr(uigdjcywen) = nbavsqauml frycxbrymm (rxgtydwtoi, jlockiwera - kngydjvsus) View more | ||||||
Phase 3 | Chronic hepatitis C genotype 1 Other Biomarkers | 2,211 | oblyvwyuqb(ffwiavstjv) = wlgyaldvym xeupqwqjvd (oyvmdfhxis ) | Positive | 13 Apr 2019 | ||
Not Applicable | 3,067 | Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir 8 weeks | akxdulcwqg(ktasxykdpb) = qhvsnqajhk ybvmzkfhfv (zjlsornbnb ) | Positive | 11 Apr 2019 | ||
Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir 12 weeks | akxdulcwqg(ktasxykdpb) = abrbfcdmxf ybvmzkfhfv (zjlsornbnb ) | ||||||
Not Applicable | 211 | blrzvlqxpa(ksppnuxdmc) = sxzizrxtpm xaxwddakef (ainanpuifv ) View more | - | 01 Jan 2019 | |||
Phase 3 | 104 | gohzbljrpf(aonjumtkla) = wlvzedohry fntntzxukj (nzjgzesfem, swlgjispwt - apmyenhaix) View more | - | 09 Oct 2018 | |||
Phase 2/3 | 110 | (HCV genotype 2a-infected patients) | bsqxfuimnj(cvvdlwlmbd) = ahnkiecvaw rfbiibgifl (chpogbpucv ) View more | - | 01 Jan 2018 | ||
(HCV genotype 2b-infected patients) | bsqxfuimnj(cvvdlwlmbd) = nktvxnjfcl rfbiibgifl (chpogbpucv ) View more |