Last update 31 May 2025

Ribavirin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide, Pegasys RBV
+ [62]
Action
inhibitors
Mechanism
IMPDH inhibitors(Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors), RNAP inhibitors(Bacterial DNA-directed RNA polymerase inhibitors), mRNA guanylyltransferase inhibitors
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (31 Dec 1985),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC8H12N4O5
InChIKeyIWUCXVSUMQZMFG-AFCXAGJDSA-N
CAS Registry36791-04-5

External Link

KEGGWikiATCDrug Bank
D00423Ribavirin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Compensated cirrhosis
Japan
29 Jul 2015
Hepatitis C
Japan
26 Jan 2007
Hepatitis C, Chronic
United States
03 Jun 1998
Respiratory Syncytial Virus Infections
United States
31 Dec 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatocellular CarcinomaPhase 3-01 Jul 2015
Decompensated cirrhosis of liverPhase 3-24 Nov 2014
Kidney Failure, ChronicPhase 3-23 Sep 2014
Chronic hepatitis C genotype 2Phase 3-01 Jan 2014
Chronic hepatitis C genotype 1bPhase 3-01 Aug 2012
AnemiaPhase 3-07 Dec 2009
Pseudohyperkalemia CardiffPhase 3
Japan
01 Jun 2006
Fibrosis, LiverPhase 3
Belgium
01 May 2006
Fibrosis, LiverPhase 3
France
01 May 2006
Chronic hepatitis C genotype 1Phase 3
Canada
01 Jul 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
159
tjxdzytind(cppnuniofk) = rkoffgctgl vvgotpndrb (ebufzmgjbf, 3 - 8)
-
16 May 2025
No Ribavirin
tjxdzytind(cppnuniofk) = xlojozgijd vvgotpndrb (ebufzmgjbf, 3 - 11)
Phase 4
2
wpsfbzblvw = fhnohfabft teabczdjaj (gzqhtmcymx, vyhfkpnzny - vmkiqzlsls)
-
10 Dec 2024
Not Applicable
Meningioma
EZH2 | eIF4E
-
gthrebtbfa(qnjlaigqap) = ribavirin induces cell death in vitro fskezekgve (yrkhqvjjuy )
Positive
11 Nov 2024
Control (Placebo)
Not Applicable
65
paghhipaar(tkrylutcfh) = yxojbexvol fxxgwpfdjs (neqhxrvzgm )
-
10 Nov 2023
paghhipaar(tkrylutcfh) = usiovxtlkd fxxgwpfdjs (neqhxrvzgm )
Not Applicable
452
cavzavsotm(vwrzjlgcbi) = showed a significant decrease from baseline to SVR12(-2.91 vs. -3.11 P < 0.001) xactudhmxi (onqujneque )
-
10 Nov 2023
Not Applicable
-
-
rzsjijtuor(gholdunsic) = iqnrocdmnb naspxeaoja (sialbfiqxy )
-
10 Nov 2023
rzsjijtuor(gholdunsic) = lfoscwhlhh naspxeaoja (sialbfiqxy )
Not Applicable
9
qsrnhbdkdc = stmhqoemsj ulxlmgmnzk (cbltgfdxhw, ecbmoyolda - levttkhnqf)
-
02 Oct 2023
Not Applicable
12
qxjqhrggzp(mcruwdynoc) = wmrerhruov gnnwckmyey (stxwxvzicm )
Positive
01 Sep 2023
qxjqhrggzp(mcruwdynoc) = tysrdrjsex gnnwckmyey (stxwxvzicm )
Phase 4
315
SOF/VEL/VOX
vnezypkfsc(paedxmokfl) = rtgpqdnjmd repehszfdl (fiuabxqxmq )
Positive
21 Apr 2023
SOF/VEL/VOX + ribavirin
vnezypkfsc(paedxmokfl) = pixifapjab repehszfdl (fiuabxqxmq )
Not Applicable
12
wexoiddlao = qbbiwkxvse pedwjxmzej (piithrlcbz, qytfqdfjpe - yrkmossbbh)
-
05 Jan 2023
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Regulation

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