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Last update 04 Aug 2026

Teicoplanin

Last update 04 Aug 2026

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Glycopeptide antibiotic, Cyclic Peptide

Synonyms

TEIC, Teichomycin, Teichomycin A2

+ [13]

Target-

Action

inhibitors

Mechanism

Cell wall inhibitors

Therapeutic Areas

Infectious DiseasesRespiratory DiseasesSkin and Musculoskeletal Diseases+ [1]

Active Indication

EmpyemaHemorrhagic SepticemiaPneumonia+ [4]

Inactive Indication

Cystic FibrosisGram-Positive Bacterial Infections

Originator Organization

Sanofi

Active Organization

Sanofi

Sun Yat-Sen University

Inactive Organization

Suzhou NeuPharma Co., Ltd.Gruppo Lepetit SRL

Neupharma Srl

License Organization

Italfarmaco SpA

Astellas Pharma, Inc.Rare Partners Srl Impresa Sociale

+ [3]

Drug Highest PhaseApproved

First Approval Date

Japan (10 Apr 1998),

EmpyemaHemorrhagic SepticemiaPneumonia+ [2]

RegulationOrphan Drug (United States), Orphan Drug (European Union)

Clinical Trials associated with Teicoplanin

CTIS2025-524264-38-00

/ RecruitingPhase 4IIT

Phase IV, randomized, open label, parallel groups clinical trial for evaluating the early Stop of antibiotic Treatment in high-risk febrile neutropenic Oncohaematological Paediatric patients (e-STOP 2)

Start Date02 Jun 2026

Sponsor / Collaborator-

CTIS2024-516232-10-00

/ Not yet recruitingPhase 4IIT

Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.

Start Date01 Dec 2025

Sponsor / Collaborator

Centre Hospitalier Universitaire de Nimes

NCT06818565

/ Not yet recruitingNot ApplicableIIT

Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections.

Acute on chronic liver failure patients are at high risk for nosocomial infections due to liver dysfunction, which impairs immune responses and increases vulnerability to infections. Key factors contributing to nosocomial infections in ACLF patients include ascites, use of invasive devices, and recent hospitalization, frequent need for broad spectrum antibiotics. Multidrug resistance is a growing issue, making treatment more challenging, common pathogens involved are gram negative bacteria such as Escherichia Coli and Klebsiella pneumoniae. Surveillance data show increasing carbapenem resistant enterobacterales (CRE) infection rates in cirrhotics, with high morbidity and mortality rates. The impact of these nosocomial infections is profound, significantly worsen outcomes in ACLF patients, leading to prolonged hospitalizations, increased health care costs and higher mortality rates. Early detection and effective antibiotic stewardship are essential to manage antibiotic resistance and improve patient outcomes. In this study we aim to compare efficacy and safety of Ceftazidime avibactam versus extended infusions of high dose Meropenem in patients of ACLF with nosocomial infections.

Start Date10 Feb 2025

Sponsor / Collaborator

Institute of Liver & Biliary Sciences

100 Clinical Results associated with Teicoplanin

100 Translational Medicine associated with Teicoplanin

100 Patents (Medical) associated with Teicoplanin

3,673

Literatures (Medical) associated with Teicoplanin

01 Sep 2026·Journal of Global Antimicrobial Resistance

Daptomycin-resistant Staphylococcus capitis: Mechanisms, molecular epidemiology, and clinical aspects

Article

Author: Hong, Yueqin ; Chen, Mengzhen ; Zhang, Junxiong ; Zhuang, Hemu ; Chen, Yiyi ; Jiang, Shengnan ; Chen, Yan ; Zhu, Feiteng ; Wang, Zhengan ; Wang, Haiping ; Sun, Lu ; Gu, Chao

OBJECTIVE:

Methicillin-resistant coagulase-negative staphylococci are important nosocomial pathogens. Studies on daptomycin (DAP) resistance in coagulase-negative staphylococci focus on Staphylococcus epidermidis, but few on Staphylococcus capitis despite its clinical and epidemiological importance. This study investigates the DAP susceptibility and underlying resistance mechanisms of methicillin-resistant S. capitis (MRSC) isolated from patients.

METHODS:

Clinical MRSC strains collected in China between 2018 and 2020 were analysed. The minimum inhibitory concentrations (MICs) were determined by agar dilution and broth microdilution methods. Molecular typing of S. capitis was performed using multilocus sequence typing. Whole-genome sequencing was performed to analyse mutations between DAP-resistant and -susceptible strains, which were further validated by phenotypic assays.

RESULTS:

A total of 101 MRSC strains were analysed, of which 99.01% (100/101) were DAP-susceptible, and 48.51% (49/101) exhibited reduced susceptibility (MIC > 0.5 µg/mL) - including 1 strain (0.99%) that was resistant (MIC = 4 µg/mL). ST1 (38.61%), ST6 (35.64%), and ST3 (6.93%) were dominant. ST6 strains were significantly more susceptible to DAP than ST1 (P < 0.001). No cross-resistance was observed between DAP and vancomycin (P = 0.604) or teicoplanin (P = 0.143). In the DAP-resistant strain, two novel mutations (mprF-A784L, yycF-H120P) were identified. Complementation of mutant mprF restored DAP resistance (MIC = 2 µg/mL) while increasing susceptibility to β-lactams. This 'seesaw effect' provides valuable insights for the treatment of MRSC infections.

CONCLUSIONS:

This study provides in vitro DAP activity data for S. capitis and identifies novel mprF mutations affecting its susceptibility to DAP and β-lactams.

01 Sep 2026·Journal of Global Antimicrobial Resistance

Genome sequence of a methicillin-resistant Staphylococcus epidermidis (MRSE) resistant to dalbavancin and teicoplanin isolated in Italy, 2023

Article

Author: Cotrufo, Marco ; Tascini, Carlo ; Curcio, Francesco ; Lombardo, Cinzia ; Moreal, Chiara ; Cojutti, PierGiorgio ; Giuliano, Simone ; Bulfoni, Michela ; Pea, Federico ; Gaibani, Paolo

OBJECTIVE:

Methicillin-resistant Staphylococcus epidermidis (MRSE) is a commensal bacterium that colonizes the skin surface of humans and animals and represents an important opportunistic pathogen related to nosocomial and community-acquired infections. Here, we characterized the whole genome of an MRSE isolate, named SEPI150, resistant to dalbavancin and teicoplanin, collected from the blood of a patient with recurrent bacteraemic episodes.

METHODS:

DNA sequencing was performed using a hybrid approach with Illumina MiSeq and Minion Oxford Nanopore platforms. Hybrid de novo assembly was performed using Unicycler, and analysis of mutations or insertions was performed by mapping Illumina reads of an MRSE strain susceptible to dalbavancin and teicoplanin collected from the same patient against the assembled genome of the SEPI150 strain.

RESULTS:

The SEPI150 strain exhibited resistance to β-lactams, rifampicin, gentamicin, dalbavancin and teicoplanin, while remaining susceptible to vancomycin. The strain belonged to sequence type ST23 and carried different antimicrobial resistance determinants (aant(9)-Ia, aadD, aac(6')-aph(2''), mecA, blaZ, erm(A) and bleO). Genome analysis in comparison with the dalbavancin-susceptible MRSE strain isolated from the same patient demonstrated that the SEPI150 strain carried wild-type walK/R, pbps and varR/S genes, and specific mutations were observed within rpoB (F597L) and vraG (D470G) genes.

CONCLUSIONS:

Herein, we hypothesized that accumulation of different mutations within genes targeting different pathways (i.e., RNA transcription and cell-wall biosynthesis) may be involved in resistance to dalbavancin and cross-resistance with other glycopeptides.

01 Aug 2026·JOURNAL OF INFECTION AND CHEMOTHERAPY

Effect of body composition on initial teicoplanin dosing and optimization of the regimen

Article

Author: Oda, Kazutaka ; Kondo, Shoji ; Jono, Hirofumi

BACKGROUND:

Teicoplanin dosing in obese or underweight patients is uncertain due to its unique pharmacokinetic variability, potentially resulting in suboptimal exposure. This study seeks to establish a dosing strategy tailored to body composition by assessing the initial teicoplanin dosing regimen using different weight indices alongside actual body weight (ABW).

METHODS:

This retrospective study involved adult patients who were administered intravenous teicoplanin at Kumamoto University Hospital between 2017 and 2023. The ratio of initial trough concentration (μg/mL, C) to the total teicoplanin loading dose administered within 24 h (mg/kg/24 h, D) was evaluated based on body composition.

RESULTS:

A total of 160 patients were included in the analysis. The mean C/D ratios were 0.42 ± 0.13, 0.52 ± 0.14, and 0.66 ± 0.14 in patients classified as underweight (BMI: <18.5 kg/m², n = 32), normal weight (BMI: 18.5 to <25 kg/m², n = 88), and obese (BMI: ≥25 kg/m², n = 40), respectively (P < 0.001, Tukey's honestly significant difference test). Bayesian-predicted pharmacokinetic parameters indicated that the smallest prediction errors were observed when ABW was used for underweight and normal-weight patients (43.8 ± 5.5 kg and 56.0 ± 7.2 kg, respectively). In contrast, standard body weight (SBW) and ideal body weight (IBW) yielded the lowest errors in obese patients.

CONCLUSIONS:

Teicoplanin loading doses should be increased by ∼20% in underweight patients and decreased by ∼20% in obese patients compared to those in normal-weight patients. SBW- or IBW-based dosing is recommended in obese patients to prevent overexposure.

News (Medical) associated with Teicoplanin

26 Apr 2024

·www.biospace.com

Bruker Further Enhances Clinical Microbiology & Infection Diagnostics Portfolio at ESCMID Global 2024 Conference

New MBT Pathfinder® IVD robot for automated MALDI Biotyper® target preparation New LiquidArray® MTB-XDR panel for simultaneous detection of M. tuberculosis complex bacteria, and their resistances to five WHO-recommended second-line drugs against multidrug-resistant tuberculosis Pending ELITech acquisition has received all regulatory clearances; closing now expected in the second quarter of 2024 BARCELONA, Spain--(BUSINESS WIRE)-- At the ESCMID Global 2024 conference, Bruker is enhancing its innovative diagnostic solutions in microbial identification, antimicrobial susceptibility testing (AST), early sepsis diagnostics, and other infectious disease assays. Simplifying microbiology and infectious disease diagnostics and workflows in the clinical laboratory is a key goal for Bruker in support of earlier and improved patient treatment decisions. This press release features multimedia. View the full release here: MBT Pathfinder® IVD with Feeder IVD (Photo: Business Wire) Microbial identification – towards automated sample preparation The latest MALDI Biotyper® workflow uses MBT Compass HT IVD software to increase throughput up to 600 samples per hour, and automated instrument tuning via IDealTune™. An optional workflow now offers semi-automated sample preparation via the MBT Pathfinder® IVD robot to avoid time-consuming, repetitive and error-prone manual tasks. Sepsis – when every minute counts When the correct antibiotic treatment for sepsis is given quickly, outcomes can improve dramatically. The IVD-CE MALDI Biotyper®, used in conjunction with the MBT Sepsityper® IVD Kit, can identify pathogens within 20 minutes from a positive blood culture bottle. Bruker offers additional clinical workflows for rapid functional antibiotic resistance testing, like the MBT STAR®-Carba IVD assay for the detection of carbapenemase activity. Antimicrobial susceptibility testing (AST) AST can indicate which antimicrobial regimen is effective for patients. Bruker’s UMIC® tests deliver accurate results for single antibiotics and combinations, and the MICRONAUT range offers AST of multiple antibiotics in a single test in a user-friendly workflow in compliance with CLSI/EUCAST recommendations. The UMIC® portfolio covers five antibiotics and combinations, namely colistin, piperacillin-tazobactam, vancomycin/teicoplanin, daptomycin and cefiderocol. In addition, Bruker is developing the new MBT-fAST assay for rapid AST of gram-negative bacteria from positive blood cultures directly on the MALDI Biotyper® platform. The MBT-fAST clinical studies are planned for the second half of 2024. Bruker also intends concurrent clinical studies for IVDR certification of lipid A-based colistin resistance detection. This and the on-going development of microbial species and subspecies differentiation based on lipid patterns will further enhance the value of the MALDI Biotyper® sirius system for clinical laboratories. The MALDI Biotyper® sirius stands out as the first MALDI-TOF mass spectrometry system for microbial identification that uses the negative ion mode for microbial lipid analysis. Currently, this feature is for Research Use Only (RUO), setting the stage for forthcoming clinical applications. Outbreak control The Bruker IR Biotyper® enables efficient microbial strain typing of bacteria and yeasts for real-time epidemiological surveillance for a range of disease-causing pathogens. During outbreak scenarios within hospitals, the IR Biotyper can help prevent the spread of hospital-acquired infections (HAI). The IR Biotyper® for hospital hygiene and infection control can be combined with the MALDI Biotyper® for microbial species identification. LiquidArray® – next-generation syndromic panels The new LiquidArray® Gastrointestinal syndromic panel facilitates the simultaneous detection of up to 26 pathogens responsible for gastroenteritis. This streamlines clinical decision-making by allowing the simultaneous analysis of multiple targets from a single sample. The rise of multidrug-resistant and extensively drug resistant M. tuberculosis strains has added complexity to TB diagnosis and treatment – and global travel is causing re-emergence in formerly low risk countries. Bruker’s new multiplex mycobacteria test LiquidArray® MTB-XDR VER 1.0, detects TB-causing bacteria of the M. tuberculosis complex and identifies resistance to five WHO-recommended second-line drugs. Dr. Wolfgang Pusch, President of the Bruker Microbiology & Infection Diagnostics division, commented: “Bruker is committed to innovation in routine microbiology and infectious disease testing. This includes nearly universal microbial identification with the MALDI Biotyper®, rapid blood culture analysis with the MBT Sepsityper® IVD Kit, early implementation of diagnostics for new antibiotics with our UMIC® portfolio, real-time epidemiological surveillance with the IR Biotyper®, and syndromic panels with our LiquidArray® assay portfolio.” Pending ELITechGroup Acquisition Regulatory Clearances As announced on February 28, 2024, Bruker Corporation has signed a Share Purchase Agreement to acquire ELITechGroup, excluding the ELITech clinical chemistry business. All regulatory clearances for this acquisition have now been received, and closing of the acquisition is expected during Q2 2024, subject to remaining closing conditions. About Bruker Corporation – Leader of the Post-Genomic Era (Nasdaq: BRKR) Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit . View source version on businesswire.com: Contacts Trade Press & Customer Contact: Philip Perry Senior Vice President, Marketing and Product Management Bruker Microbiology & Infection Diagnostics Division T: +49-172-313-7216 E: philip.perry@bruker.com Investor Contact: Justin Ward Sr. Director, Investor Relations & Corporate Development Bruker Corporation T: +1 (978) 313-5800 E: Investor.Relations@bruker.com Source: Bruker Corporation Smart Multimedia Gallery Photo MBT Pathfinder® IVD with Feeder IVD (Photo: Business Wire) Photo LiquidArray® MTB-XDR VER 1.0 (Photo: Business Wire) Logo View this news release and multimedia online at:

Acquisition

15 Mar 2024

·www.fiercepharma.com

EuroAPI's troubles mount as audit reveals manufacturing lapses in Italy, spurring 2024 guidance suspension

As EuroAPI investigates the situation, production at its Italian facility in Brindisi will remain suspended until further notice. Beleaguered Sanofi spinout EuroAPI can’t seem to catch a break. After reporting ballooning losses and a four-year restructuring plan last month, the company revealed Thursday that manufacturing lapses at an Italian plant have temporarily derailed its guidance for the year. EuroAPI’s Italian subsidiary is suspending production of all active pharmaceutical ingredients (APIs) at its plant in Brindisi after an internal audit uncovered quality control deficiencies “due to potential local misconduct,” the company said in a release. As the manufacturer investigates the situation, production at the facility will remain suspended until further notice, EuroAPI added. The situation is likely to weigh on the company's operational and financial performance for 2024, EuroAPI warned, so it's suspending its guidance for the year. A revised 2024 outlook is being planned for release in the year’s second quarter. The Brindisi site produces 11 APIs and intermediates, which primarily consist of anti-infectives including spiramycin, rifaximin, rifampicin and teicoplanin. Last year, sales from the Italian facility clocked in at 63 million euros (around $69 million). While sales from the site are "limited," the production lapse could have an “image impact” on the company in relation to its clients, ODDO BHF analysts wrote to clients. Given the evolving situation at EuroAPI, the ODDO team has slashed 52 million euros from its topline forecast for the company and is now predicting a sales decline of 11%, versus the 6% revenue slump the analysts had previously projected. Since EuroAPI’s market debut as a standalone API maker and CDMO in May 2022, the company has encountered numerous hurdles that have threatened its goal to become a “partner of choice for all pharmaceutical and biotech companies.” Last month, in tandem with the company’s 2023 earnings report, EuroAPI appointed a new CEO and unveiled a four-year restructuring scheme dubbed FOCUS-27, which will involve streamlining the company’s API portfolio, focusing its CDMO activities, rationalizing its industrial footprint and becoming an altogether “leaner organization.” Naturally, potential layoffs are a part of the plan, which could see job cuts across “all functions” at the company, including industrial operations, quality, R&D and support roles. As part of the plan, EuroAPI said at the time that its attempt to focus on higher-value APIs could result in potential sales of its sites in Brindisi, Italy, and Haverhill, England. As the ODDO BHF team sees it, the transformation and restructuring costs under FOCUS-27 could be “made worse” now that EuroAPI will need to get its Brindisi plant up to standard before a potential sale. For all of 2023, EuroAPI reported net sales growth of 4% to 1.01 billion euros (about $1.09 billion). The company logged a net loss of 189.7 million euros.

Financial Statement

14 Mar 2024

·www.globenewswire.com

Full-year 2024 guidance suspended due to the temporary pause of API production at the Brindisi site in Italy

Press Release Paris – March 14th, 2024 – EUROAPI today announces that its Italian subsidiary, EUROAPI Italy S.R.L., is suspending the production of all APIs1 in Brindisi. Following an internal audit, quality control deficiencies due to potential local misconduct have been identified and are being further investigated. Production will remain suspended until further notice. The relevant health authorities have been informed. The company has initiated a forensic audit and will inform its customers. The Brindisi site produces 11 APIs and intermediates, mostly anti-infectives (including spiramycin, rifaximin, rifampicin and teicoplanin). In 2023, sales related to the Brindisi site amounted to 63 million euros, of which 43% related to Sanofi. The value of Brindisi non-current assets has been fully impaired in 2023 Consolidated Accounts. This situation is expected to impact the Group's operational and financial performance. Consequently, the full-year 2024 guidance is suspended. A revised full-year 2024 outlook will be provided in Q2 2024, along with the planned communication on the implementation and the financing of the FOCUS-27 project announced on February 28th, 2024. Conference call today at 07:45 PM CET EUROAPI management will hold a live audio webcast today at 07:45 PM CET (https://channel.royalcast.com/landingpage/euroapi-eng/20240314_1/). To participate in the Q&A session, please dial in the following numbers: France: +33 (0) 1 70 37 71 66UK: +44 (0) 33 0551 0200US: +1 786 697 3501 Media Relations contact:Laurence BollackTel.: +33 (0)6 81 86 80 19mr@euroapi.com Investor Relations contact:Sophie Palliez-CapianTel.: +33 (0)6 87 89 33 51Sophie.palliez@euroapi.com Camile RicotierTel : +33 (0)6 43 29 93 79Camille.ricotier@euroapi.com Financial Calendar March 26th, 2024: Publication of the 2023 Universal Registration Document May 22nd, 2024: Annual Shareholder General MeetingQ2 2024: Further information on FOCUS-27 projectJuly 31st, 2024 (before market opening): H1 2024 Results About EUROAPI EUROAPI is focused on reinventing active ingredient solutions to sustainably meet customers’ and patients’ needs around the world. We are a leading player in active pharmaceutical ingredients with approximately 200 products in our portfolio, offering a large span of technologies while developing innovative molecules through our Contract Development and Manufacturing Organization (CDMO) activities.Taking action for health by enabling access to essential therapies inspires our 3,450 people every day. With strong research and development capabilities and six manufacturing sites, all located in Europe, EUROAPI ensures API manufacturing of the highest quality to supply customers in more than 80 countries. EUROAPI is listed on Euronext Paris; ISIN: FR0014008VX5; ticker: EAPI). Find out more at www.euroapi.com and follow us on LinkedIn. Forward-looking statements Certain information contained in this press release is forward looking and not historical data. These forward-looking statements are based on opinions, projections and current assumptions including, but not limited to, assumptions concerning the Group’s current and future strategy, financial and non-financial future results and the environment in which the Group operates, as well as events, operations, future services or product development and potential. Forward-looking statements are generally identified by the words “expects”, “anticipates”, “believes”, “intends”, “estimates”, “plans” and similar expressions. Forward looking statements and information do not constitute guarantees of future performances, and are subject to known or unknown risks, uncertainties and other factors, including social risks, a large number of which are difficult to predict and generally outside the control of the Group, which could cause actual results, performances or achievements, or the results of the sector or other events, to differ materially from those described or suggested by these forward-looking statements. These risks and uncertainties include those that are indicated and detailed in Chapter 3 “Risk factors” of the Universal Registration Document approved by the French Financial Markets Authority (Autorité des marchés financiers, AMF) on April 14, 2023, under number R.23-009 and the Amendment to Universal Registration Document approved by the AMF on April 25, 2023 under number R.23-015 (which are both available at www.euroapi.com). These forward-looking statements are given only as of the date of this press release and the Group expressly declines any obligation or commitment to publish updates or corrections of the forward-looking statements included in this press release in order to reflect any change affecting the forecasts or events, conditions or circumstances on which these forward-looking statements are based.” 1 API : Active Pharmaceutical Ingredients Attachment EUROAPI press release - March 14, 2024

100 Deals associated with Teicoplanin

External Link

KEGG	Wiki	ATC	Drug Bank
D02142	Teicoplanin	J01XA02	DB06149

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Empyema	Japan	Sanofi	10 Apr 1998
Hemorrhagic Septicemia	Japan	Sanofi	10 Apr 1998
Pneumonia	Japan	Sanofi	10 Apr 1998
Skin and skin structure infections	Japan	Sanofi	10 Apr 1998
Skin Diseases	Japan	Sanofi	10 Apr 1998
Gram-Positive Bacterial Infections	China	Gruppo Lepetit SRL	-

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Cystic Fibrosis	Phase 1	Italy	Suzhou NeuPharma Co., Ltd.	25 Oct 2019
Cystic Fibrosis	Phase 1	Italy	Neupharma Srl	25 Oct 2019
Hemorrhagic Fever, Ebola	Preclinical	China	Sun Yat-Sen University	01 Apr 2016
Severe Acute Respiratory Syndrome	Preclinical	China	Sun Yat-Sen University	01 Apr 2016

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Pubmed \| Int J Antimicrob Agents	Phase 4	Bacteremia	44	Teicoplanin lock therapy	eomdeuhjkl(kewmaaspkl) = qngpdiyftj thvejgvrvo (frkqgrkfuy ) View more	Positive	01 Nov 2009
				Vancomycin lock therapy	eomdeuhjkl(kewmaaspkl) = qfuqnnhyrc thvejgvrvo (frkqgrkfuy )

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