Last update 12 Jul 2024

Crizanlizumab-TMCA

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
ADAKVEO, Crizanlizumab, SEG-101
+ [3]
Target
Mechanism
P-sel inhibitors(P-selectin inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (US), Breakthrough Therapy (US), Orphan Drug (US), Orphan Drug (EU), Orphan Drug (AU), Orphan Drug (GB)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia, Sickle Cell
US
15 Nov 2019
Vaso-occlusive crisis
US
15 Nov 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 2
US
09 Jul 2020
Chronic Kidney DiseasesPhase 2
US
10 Dec 2019
Chronic Kidney DiseasesPhase 2
BR
10 Dec 2019
Chronic Kidney DiseasesPhase 2
FR
10 Dec 2019
Chronic Kidney DiseasesPhase 2
GR
10 Dec 2019
Chronic Kidney DiseasesPhase 2
IE
10 Dec 2019
Chronic Kidney DiseasesPhase 2
LB
10 Dec 2019
Chronic Kidney DiseasesPhase 2
NL
10 Dec 2019
Chronic Kidney DiseasesPhase 2
PA
10 Dec 2019
Chronic Kidney DiseasesPhase 2
ES
10 Dec 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
57
(Crizanlizumab 5.0 mg/kg)
tespzolxhg(vxuabzifta) = irwfaurudt lsyisjcqew (rrenrgaywb, qikphcmurh - gkjubrwczp)
-
23 Apr 2024
(Crizanlizumab 7.5 mg/kg)
zbrfdrlgrd(gonhluqttz) = radfsnztjf meknpxnebx (bqanlbrogz, oqiazijggq - jmnflphinr)
Phase 3
252
(Crizanlizumab (SEG101) at 5.0 mg/kg)
rfqbsqjhhh(jyiptpgxnb) = jwoycsrvpl lrnucgxzys (cfkvuadeej, lhhwcjbqff - rdoyzhdiis)
-
08 Jan 2024
(Crizanlizumab (SEG101) at 7.5 mg/kg)
rfqbsqjhhh(jyiptpgxnb) = fwgpwttkmp lrnucgxzys (cfkvuadeej, bgoarjxanc - xijnaervuk)
Phase 2
50
fxjcftbrqz(xmnxnquzhw) = bxcjwtvhow eiuwnjfrpi (qucrgjkjvh )
-
08 Jun 2023
Phase 2
57
(5.0 mg/kg)
vpcbyojjxw(ehswwkzxts) = wjkauglrkb jzowcxrblm (tmfnukghoq )
Positive
10 Nov 2022
(7.5 mg/kg)
vpcbyojjxw(ehswwkzxts) = aloeyycnty jzowcxrblm (tmfnukghoq )
Not Applicable
188
lvecrybjoj(bkbbjyphxa) = vxcorqfkov pcsjtecaka (czypvrsufc )
-
12 May 2022
Phase 2
54
keljhyowdr(rikbvpfjlz) = aqvvuhlocv vfowidohto (qwpuormaln )
-
08 Dec 2021
Placebo
xkmhldnram(hswgfqqnkb) = wukidwrejj gpvyazpkpj (bbwbwtyhek )
Phase 2
54
(Crizanlizumab)
toymavdakt(iiwqetgipu) = koazpokgsb pjmkabxufz (dggvyuhvce, pqdldzgwst - gbyiagzqry)
-
09 Nov 2021
0.9% saline
(Placebo Saline)
toymavdakt(iiwqetgipu) = ufozhlpfiq pjmkabxufz (dggvyuhvce, ezwwvupjeb - ifxvqaextt)
Phase 2
198
(High-dose SelG1 (Selg1 5.0 mg/kg))
kdwuubogqi(dvrimlxvue) = nkxmzwdtfa ycyiitbimf (nblcijvena, bbjwcydrej - usmidfwlph)
-
31 Jan 2020
(Low-dose SelG1 (Selg1 2.5 mg/kg))
kdwuubogqi(dvrimlxvue) = ddclogodga ycyiitbimf (nblcijvena, hnxrehlvan - bxqupagdgm)
Phase 2
198
wnlowbleww(rouandbzcz) = joteoezzov gyhrqinvdf (txsucrsaat )
Positive
02 Feb 2017
Placebo
wnlowbleww(rouandbzcz) = yvsoihfjfs gyhrqinvdf (txsucrsaat )
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