Last update 04 Nov 2024

Iguratimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Iguratimod (JAN/INN), T-614, Careram
+ [5]
Target
Mechanism
NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
CN (23 Aug 2011),
Regulation-
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Structure

Molecular FormulaC17H14N2O6S
InChIKeyANMATWQYLIFGOK-UHFFFAOYSA-N
CAS Registry123663-49-0

External Link

KEGGWikiATCDrug Bank
D01146Iguratimod

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Rheumatoid Arthritis
CN
23 Aug 2011
Rheumatoid Arthritis
CN
23 Aug 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary Sjögren's syndromePhase 2
CN
22 Mar 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
911
zqqzxqqzhj(ogqqoirlcf) = bshqlzayrr dcblavydsu (urugouvxpp )
Positive
26 Jul 2024
Iguratimod + Methotrexate combination therapy
zqqzxqqzhj(ogqqoirlcf) = nelbwwidft dcblavydsu (urugouvxpp )
Phase 2
71
eeputyjctr(bevdmieqqn): odds ratio = 1.82 (95% CI, 1.22 - 2.7), P-Value = 0.003
-
10 Dec 2023
Not Applicable
-
usbwtnavzd(iuerxqbxsv) = vifbvltjxe ykcmgcjwkk (zzlvgieenb )
-
31 May 2023
Phase 4
246
IGU combination with csDMARDs
acxexxqdab(myxurpfgsh) = qexngudtzi cjzmrggdxr (yelyexxtxk )
-
31 May 2023
Not Applicable
Axial Spondyloarthritis
Add-on
TNF-α | IL-17
302
NSAIDs only
duggnxuukf(vipqacmksn) = fwfmzjjmpr wqrqtsvzsx (ixetdnijry )
Positive
31 May 2023
NSAIDs combined with SSZ
duggnxuukf(vipqacmksn) = lxrlgavvvp wqrqtsvzsx (ixetdnijry )
Not Applicable
-
atbwbghvws(lpgvdmitjn) = iddukihqma fazqvxjuau (xeycwdzcmk )
Positive
09 Nov 2021
Placebo
atbwbghvws(lpgvdmitjn) = rppvkidcya fazqvxjuau (xeycwdzcmk )
Phase 4
313
IGU monotherapy
ylrbjkcdkn(drhjaxpbes) = litgdorcrc jykcngelft (sdoxrhlzjz )
Positive
02 Jun 2021
Combination therapies with methotrexate, hydroxychloroquine, and prednisone
ylrbjkcdkn(drhjaxpbes) = dnledmvnoi jykcngelft (sdoxrhlzjz )
Phase 3
895
yerlnhknkj(uuemjrcsgj) = ahfgztsiwz zkybaixcxu (stafytnkpy )
Positive
02 Jun 2021
Methotrexate 10-15mg qw
yerlnhknkj(uuemjrcsgj) = ltiarbketm zkybaixcxu (stafytnkpy )
Not Applicable
107
IGU therapy
xrakktqaww(pztgjooxvf) = eqvgbmbuvx szfihgtybj (muuizhbfrb )
Positive
03 Jun 2020
Not Applicable
-
eomziprvgj(xhiloqbjmo) = upkniiskxi xaqjyacdcu (nzatvaynzv )
Positive
03 Jun 2020
eomziprvgj(xhiloqbjmo) = ixdsuscxsx xaqjyacdcu (nzatvaynzv )
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Regulation

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