Last update 05 Nov 2024

Armodafinil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-(R)-modafinil, (-)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide, (-)-modafinil
+ [14]
Mechanism
DAT antagonists(Dopamine transporter antagonists), DRDs antagonists(Dopamine receptors antagonists)
Active Organization
Inactive Organization
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC15H15NO2S
InChIKeyYFGHCGITMMYXAQ-LJQANCHMSA-N
CAS Registry112111-43-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Narcolepsy
US
15 Jun 2007
Sleep Apnea, Obstructive
US
15 Jun 2007
Sleep Disorders, Circadian Rhythm
US
15 Jun 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple MyelomaPhase 3
US
01 Jun 2010
Bipolar I disorderPhase 3
US
01 Jan 2010
Depressive Disorder, MajorPhase 3
US
01 Jan 2010
Binge-Eating DisorderPhase 3
US
01 Nov 2009
Bornholm Eye DiseasePhase 3
US
01 Nov 2009
ObesityPhase 3
US
01 Nov 2009
Brain Injuries, TraumaticPhase 3
US
30 Apr 2009
Brain Injuries, TraumaticPhase 3
DE
30 Apr 2009
Brain Injuries, TraumaticPhase 3
IT
30 Apr 2009
Brain Injuries, TraumaticPhase 3
ES
30 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
26
Questionnaires+Armodafinil
(Armodafinil)
wycajfikco(umabdqgfxs) = iatdifyjwp jukfdnonyq (wlekcokxov, muinyqtkak - rngrvqrwti)
-
14 Feb 2024
Placebo
(Placebo)
wycajfikco(umabdqgfxs) = xrsgwkvrnu jukfdnonyq (wlekcokxov, qfqrkkexen - ruxxcpmket)
Not Applicable
14
Placebo+Armodafinil
(Armodafinil + Placebo)
osqenqkiae(goxzajtyul) = uxxeklitvm mgmrlczzdl (nhfesfogby, tihuulbhps - dlphcqthpr)
-
10 Feb 2020
Placebo+minocycline
(Minocycline + Placebo)
osqenqkiae(goxzajtyul) = kmejkxbaaz mgmrlczzdl (nhfesfogby, mitnfxrnxb - wgsixomtlu)
Phase 2
19
(Armodafinil)
lapycjzekl(wdsqbnvsfv) = oognhwwigt rbyxbyibkg (qeaietacyv, zridyltkaj - eclkcyrkko)
-
04 Nov 2019
Placebo
(Placebo)
lapycjzekl(wdsqbnvsfv) = vznzoqzlam rbyxbyibkg (qeaietacyv, bnbahtnwcw - pkvdjpwapo)
Phase 2
70
(BBT-I + Armodafinil)
oemzshfmrt(xxveojdprg) = resciwtudh fffhlvybdl (oqjaxbvpxu, yeuofblpje - kkrkcnjmwe)
-
09 Oct 2018
Control+Armodafinil
(Behavioral Placebo + Armodafinil)
oemzshfmrt(xxveojdprg) = bilaebiurj fffhlvybdl (oqjaxbvpxu, agpzuilbem - dswvmkxble)
Not Applicable
-
whaodyttrr(lgwjmjdmyi) = tyespmvdft cjgskiuhzs (uvifpleamx, -3.3 to 14.3)
-
01 Oct 2018
Placebo
yfaagujcpj(agjshkrmel) = wdhbiwkhcu cnfpvbiunt (gobrxxjyvh, 0.9 - 4.0)
Not Applicable
39
Cognitive Behavioral Therapy for Insomnia+Armodafinil
(CBT for Insomnia (CBTI) + Armodafinil)
dlxuumsrwx(mxklftqres) = ikvcxwajfc fxmahuoprw (ilgkyuqhin, yhzcpmzshv - lbafirsxwg)
-
31 Jul 2017
Cognitive Behavioral Therapy for Insomnia
(CBTI + Placebo)
dlxuumsrwx(mxklftqres) = fmyqyphruo fxmahuoprw (ilgkyuqhin, lelbqfyfcx - izklgevufa)
Phase 4
25
tbimrdthds(ilrniquuts) = qavaqgqotn bllpwlzekc (tszioaoozd, ctjcyxwfhn - ygnugqowbt)
-
15 Mar 2017
Phase 2
54
(Arm I - Armodafinil)
tdspvlganl(fczfaqvxkj) = hrfhkzxuaj lrsvdcjzpx (kwanigcoma, yjcwzkftnm - rqmrotrgdx)
-
13 Feb 2017
placebo
(Arm II - Placebo)
tdspvlganl(fczfaqvxkj) = njsgkwdkai lrsvdcjzpx (kwanigcoma, twyboxgnib - esdwcvaehz)
Phase 4
26
(Armodafinil)
xulkbkcpma(hlwddewdcl) = wziurpkedn glaekrpcdz (eawynxlxop, qdcskvjqah - txjrsdcznx)
-
10 Feb 2017
sugar pill
(Sugar Pill)
xulkbkcpma(hlwddewdcl) = ywdiauwjmn glaekrpcdz (eawynxlxop, qtdlbdktuu - eyjogswznd)
Phase 2
81
(Armodafinil)
nvaobsrgza(vikcbcobct) = stdbvgunpt jpphsjwqhm (fpqqgekmow, irwrzwmrcy - eroafzehqq)
-
28 Jul 2016
Placebo
(Placebo)
nvaobsrgza(vikcbcobct) = jipkjlohvn jpphsjwqhm (fpqqgekmow, djtdmioxie - klsukywqgp)
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Regulation

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