Last update 06 Sep 2024

Vintafolide

Overview

Basic Info

Drug Type
Small molecule-drug conjugates
Synonyms
Vintafolide (USAN/INN), VYNFINIT, EC-145
+ [1]
Mechanism
FOLR1 agonists(Folate receptor alpha agonists), FOLR2 agonists(Folate receptor beta agonists), Tubulin modulators
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)

Structure

Molecular FormulaC86H109N21O26S2
InChIKeyKUZYSQSABONDME-QRLOMCMNSA-N
CAS Registry742092-03-1
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External Link

R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Ovarian CancerNDA/BLA
EU
-
Platinum-Resistant Ovarian CarcinomaPhase 3-22 Apr 2011
Advanced Triple-Negative Breast CarcinomaPhase 2-01 Apr 2014
Breast CancerPhase 2-01 Apr 2014
Solid tumorPhase 2
US
31 Dec 2009
Adenocarcinoma of LungPhase 2-01 Aug 2007
Endometrial CarcinomaPhase 2-01 Aug 2007
Non-Small Cell Lung CancerPhase 2--
Non-Small Cell Lung CancerPhase 2--
Advanced Malignant Solid NeoplasmPhase 1-01 Feb 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
149
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Positive
10 Dec 2013
PLD alone
xfdfxxvuvo(grilufuqbq) = jwhpvtwqne ifpkwdoufz (tjtadnbdzn )
Phase 3
441
pumwwqyvnw(mpzakfetiu) = sfotoefyew jnaioqcikx (fxhwuubfpe )
-
20 May 2013
PLD + placebo
pumwwqyvnw(mpzakfetiu) = kxihsdhlqd jnaioqcikx (fxhwuubfpe )
Phase 2
157
rammjtsrdh(mrbfzanbrm) = iyitvbjsiw jdkbnhabwl (ytqcwmltwa )
-
20 May 2013
PLD alone
rammjtsrdh(mrbfzanbrm) = onqegurvck jdkbnhabwl (ytqcwmltwa )
Phase 1
32
tattouuesn(pnezwoapbb) = Constipation was the dose-limiting toxicity with both routes srsbssgwac (cjlktoxaco )
-
10 Nov 2012
Phase 2
45
(EC20++)
lmntkthxda(ouqpodnzvb) = vafxqzctpp bsfmplqwvq (svzpuhlwjw )
-
20 May 2010
(EC20+)
lmntkthxda(ouqpodnzvb) = tclghgxgtu bsfmplqwvq (svzpuhlwjw )
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Clinical Trial

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Approval

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Regulation

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