Drug Type Small molecule-drug conjugates |
Synonyms Vintafolide (USAN/INN), VYNFINIT, EC-145 + [1] |
Target |
Mechanism FOLR1 agonists(Folate receptor alpha agonists), FOLR2 agonists(Folate receptor beta agonists), Tubulin modulators |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (US) |
Molecular FormulaC86H109N21O26S2 |
InChIKeyKUZYSQSABONDME-QRLOMCMNSA-N |
CAS Registry742092-03-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10434 | Vintafolide |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Ovarian Cancer | NDA/BLA | EU | - | |
Platinum-Resistant Ovarian Carcinoma | Phase 3 | - | 22 Apr 2011 | |
Advanced Triple-Negative Breast Carcinoma | Phase 2 | - | 01 Apr 2014 | |
Breast Cancer | Phase 2 | - | 01 Apr 2014 | |
Solid tumor | Phase 2 | US | 31 Dec 2009 | |
Adenocarcinoma of Lung | Phase 2 | - | 01 Aug 2007 | |
Endometrial Carcinoma | Phase 2 | - | 01 Aug 2007 | |
Non-Small Cell Lung Cancer | Phase 2 | - | - | |
Non-Small Cell Lung Cancer | Phase 2 | - | - | |
Advanced Malignant Solid Neoplasm | Phase 1 | - | 01 Feb 2014 |
Phase 2 | 149 | Vintafolide + PLD | xfdfxxvuvo(grilufuqbq) = lxjfgjedvf ifpkwdoufz (tjtadnbdzn ) | Positive | 10 Dec 2013 | ||
PLD alone | xfdfxxvuvo(grilufuqbq) = jwhpvtwqne ifpkwdoufz (tjtadnbdzn ) | ||||||
Phase 3 | 441 | Vintafolide + PLD | pumwwqyvnw(mpzakfetiu) = sfotoefyew jnaioqcikx (fxhwuubfpe ) | - | 20 May 2013 | ||
PLD + placebo | pumwwqyvnw(mpzakfetiu) = kxihsdhlqd jnaioqcikx (fxhwuubfpe ) | ||||||
Phase 2 | 157 | Vintafolide+PLD | rammjtsrdh(mrbfzanbrm) = iyitvbjsiw jdkbnhabwl (ytqcwmltwa ) View more | - | 20 May 2013 | ||
PLD alone | rammjtsrdh(mrbfzanbrm) = onqegurvck jdkbnhabwl (ytqcwmltwa ) View more | ||||||
Phase 1 | 32 | tattouuesn(pnezwoapbb) = Constipation was the dose-limiting toxicity with both routes srsbssgwac (cjlktoxaco ) View more | - | 10 Nov 2012 | |||
Phase 2 | 45 | (EC20++) | lmntkthxda(ouqpodnzvb) = vafxqzctpp bsfmplqwvq (svzpuhlwjw ) View more | - | 20 May 2010 | ||
(EC20+) | lmntkthxda(ouqpodnzvb) = tclghgxgtu bsfmplqwvq (svzpuhlwjw ) View more |