Delving into the Latest Updates on Tumor-infiltrating Lymphocytes(H. Lee Moffitt Cancer Center and Research Institute) with Synapse

Overview

Basic Info

Drug Type

TIL therapy

Synonyms

CD40L TIL(H. Lee Moffitt Cancer Center and Research Institute)

Target

CD40L

Action

stimulants

Mechanism

CD40L stimulants(CD40 ligand stimulants), Immunologic cytotoxicity, T lymphocyte replacements

Therapeutic Areas

NeoplasmsRespiratory DiseasesUrogenital Diseases

Active Indication

Advanced Lung Non-Small Cell Carcinomametastatic non-small cell lung cancerRecurrent Non-Small Cell Lung Cancer+ [2]

Inactive Indication-

Originator Organization

H. Lee Moffitt Cancer Center & Research Institute, Inc.

Active Organization

H. Lee Moffitt Cancer Center & Research Institute, Inc.

Inactive Organization-

Drug Highest PhasePhase 1/2

First Approval Date-

Regulation-

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Investigators plan to study the safety, side effects, and benefits of tumor-infiltrating lymphocytes (TILs) when they are given with the drug nivolumab. Nivolumab is a type of immunotherapy - a drug that is used to boost the ability of the immune system to fight cancer, infection, and other diseases.

Start Date11 Oct 2017

Sponsor / Collaborator

H. Lee Moffitt Cancer Center & Research Institute, Inc.

[+4]

100 Clinical Results associated with Tumor-infiltrating Lymphocytes(H. Lee Moffitt Cancer Center and Research Institute)

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100 Translational Medicine associated with Tumor-infiltrating Lymphocytes(H. Lee Moffitt Cancer Center and Research Institute)

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100 Patents (Medical) associated with Tumor-infiltrating Lymphocytes(H. Lee Moffitt Cancer Center and Research Institute)

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100 Deals associated with Tumor-infiltrating Lymphocytes(H. Lee Moffitt Cancer Center and Research Institute)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced Lung Non-Small Cell Carcinoma	Phase 2	United States	H. Lee Moffitt Cancer Center & Research Institute, Inc.	10 Mar 2023
metastatic non-small cell lung cancer	Phase 2	United States	H. Lee Moffitt Cancer Center & Research Institute, Inc.	10 Mar 2023
Recurrent Non-Small Cell Lung Cancer	Phase 2	United States	H. Lee Moffitt Cancer Center & Research Institute, Inc.	10 Mar 2023
Non-Muscle Invasive Bladder Neoplasms	Phase 1	United States	H. Lee Moffitt Cancer Center & Research Institute, Inc.	10 Aug 2023
Urothelial Carcinoma of the Urinary Bladder	Phase 1	United States	H. Lee Moffitt Cancer Center & Research Institute, Inc.	10 Aug 2023

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ESMO2024	Not Applicable	Unresectable Melanoma	102	Tumor Infiltrating Lymphocytes (TIL)	vcltqesrmd(petjlgythg) = ICI-related toxicity was identified in 22 patients (24%), and among those 6 patients (27%) had a recurrence of a toxicity seen with pre-TIL ICI ehieigwgmk (zfhqexldge ) View more	Negative	14 Sep 2024
ESMO2024	Not Applicable	Unresectable Melanoma	102	Immune Checkpoint Inhibitor (ICI) Rechallenge		Negative	14 Sep 2024
SITC2022	Not Applicable	Non-Small Cell Lung Cancer PD-1+ \| IFN-Î³	103	tumor-infiltrating lymphocytes (Initial Expansion (IE) TILs)	foszwzkstt(aklrmyamvv) = pnqleyymhz ukinmgxvos (axxffdlnef, 0.02 - 30.8) View more	Positive	07 Nov 2022
SITC2022	Not Applicable	Non-Small Cell Lung Cancer PD-1+ \| IFN-Î³	103	tumor-infiltrating lymphocytes (Rapid Expansion (REP) TILs)	pcuhfxpnfo(owiumzjrha) = ptelbkkgme lqtptxneev (bwldkybeuj ) View more	Positive	07 Nov 2022
SITC2016	Phase 2	Melanoma	-	TIL therapy	vqmyfjcbvb(fxpottzora) = qhpnplbbpu xchnbegvuy (jtuptwlrlg )	Positive	16 Nov 2016
SITC2014	Phase 1	Pancreatic Cancer mesothelin \| survivin \| NY-ESO-1	16	IL-2/IL-15/IL-21-expanded TIL	zzogfdnlsk(yczdsxuolc) = 1/16 TIL cultures exhibited exclusively CD4+ TIL with a CD45RA-CCR7+ phenotype mnjtbmmxoc (wjxmtiyeuq ) View more	-	06 Nov 2014
ASCO2014	Phase 2	Metastatic melanoma	56	Tumor-infiltrating lymphocytes (TIL)	wypjygswsj(tnhwaksqbq) = bgkuuneswp rchhjdduph (xaexhggeop )	Positive	20 May 2014