A Phase II Study of Type-1 Polarized Dendritic Cell (aDC1) -Based Treatment in Combination With Tumor-Selective Chemokine Modulation (CKM: Interferon Alpha 2b, Rintatolimod and Celecoxib) in Melanoma Patients With Primary PD-1/PD-L1 Resistance

This phase II trial studies how well polarized dendritic cell (aDC1) based therapy, interferon alpha-2, rintatolimod, and celecoxib work together in treating patients with HLA-A2 positive (+) melanoma that has not responded to previous treatment (refractory). The aDC1 cell-based treatment contains white blood cells (dendritic cells or DCs) that stimulates the immune system. Interferon alpha-2 can improve the body's natural response to infections and other diseases. It can also interfere with the division of cancer cells and slow tumor growth. Rintalolimid may stimulate the immune system. Celecoxib is a drug that reduces pain. This study is being done to find out if the combination of the study cell-based treatment (aDC1 dendritic cells) and interferon alpha-2, rintatolimod, and celecoxib can prevent the growth and/or progression of melanoma.

Start Date20 Nov 2024

Sponsor / Collaborator

Roswell Park Comprehensive Cancer Center

[+1]

NCT05494697 / RecruitingPhase 2

A Phase 2, Randomized, Open-Label, Controlled Study to Evaluate the Efficacy and Safety of Ampligen® Compared to Control Group / No Treatment Following FOLFIRINOX in Subjects With Locally Advanced Pancreatic Adenocarcinoma

The purpose of this study is to assess the safety and efficacy of Ampligen in patients with locally advanced pancreatic adenocarcinoma

Start Date01 Oct 2024

Sponsor / Collaborator

AIM ImmunoTech, Inc.

[+1]

NCT05756166 / RecruitingPhase 1/2IIT

Phase I/IIa Clinical Trial Evaluating the Safety and Efficacy of Rintatolimod Combined With IFNα2b (Bioferon®) to Enhance the Effectiveness of Pembrolizumab in Patients With Metastatic Triple Negative Breast Cancer

This phase I/IIa trial tests the safety, side effects, and best dose of chemokine modulation therapy (CKM) (rintatolimod, celecoxib, and interferon alpha 2b) in combination with pembrolizumab for the treatment of patients with triple negative breast cancer that has spread from where it first started (primary site) to other places in the body (metastatic) or that cannot be removed by surgery (unresectable). CKM drugs such as rintatolimod and interferon alpha 2b work to modify the immune response and tumor-related processes, including tumor cell growth, blood vessel growth, and metastasis. Celecoxib is an anti-inflammatory drug that can cause cell death and may reduce the growth of blood vessels tumors need to grow and spread. Immunotherapy such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving CKM therapy prior to pembrolizumab may direct the immune cells to the cancer cells and maximize the effectiveness of pembrolizumab in patients with metastatic or unresectable triple negative breast cancer.

Start Date16 Feb 2024

Sponsor / Collaborator

Roswell Park Comprehensive Cancer Center

[+1]

100 Clinical Results associated with Rintatolimod

100 Translational Medicine associated with Rintatolimod

100 Patents (Medical) associated with Rintatolimod

Literatures (Medical) associated with Rintatolimod

15 Aug 2024·Clinical Cancer Research

Rintatolimod in Advanced Pancreatic Cancer Enhances Antitumor Immunity through Dendritic Cell–Mediated T-Cell Responses

Article

Author: Fellah, Amine ; Aerts, Joachim G.J.V. ; Kucukcelebi, Songul ; Haddaoui, Hassana el ; Willemsen, Marcella ; Mustafa, Dana A.M. ; van Eijck, Casper W.F. ; van Eijck, Casper H.J. ; Vadgama, Disha

AbstractPurpose:Amid the need for new approaches to improve survival in pancreatic ductal adenocarcinoma (PDAC), immune-based therapies have garnered interest. Rintatolimod, a Toll-like receptor 3 (TLR-3) agonist, is a potential candidate due to its dual impact on restraining PDAC cell functions and boosting the antitumor immune response. This study investigates the effect of TLR-3 activation through rintatolimod on the peripheral immune landscape of patients with advanced PDAC.Experimental Design:Paired blood samples of 30 patients with advanced PDAC, collected at baseline and after 12 rintatolimod intravenous infusions, underwent comprehensive transcriptomic NanoString and proteomic flow cytometry profiling. The impact of rintatolimod and immunologic factors on survival outcomes was assessed through univariate Cox proportional hazards models.Results:Rintatolimod treatment enhances peripheral immune activity at the transcriptomic and proteomic levels, particularly involving type 1 conventional dendritic cells (cDC1) and T cells. Post-rintatolimod, the increased peripheral abundance of BTLA+ XCR1+ cDC1s and CD4+SELL+ T cells correlated with improved clinical outcomes. Patients with stable disease exhibited pronouncedDCand T-cell activation gene overexpression. Notably, the expression of immune checkpoints PD-L1 and PD-L2 decreased post-rintatolimod across all patients. However, those with progressive disease showed increased expression of genes encoding IDO1 and PD-1.Conclusions:This study presents compelling evidence of the immune-stimulatory properties linked to TLR-3 activation through rintatolimod. Rintatolimod may break immunologic tolerance by enhancing antitumor immunity through DC-mediated Th-cell responses. Furthermore, our findings lay the groundwork for investigating the potential synergy between TLR-3 activation and immune checkpoint inhibitor therapy to improve therapeutic outcomes.See related commentary by Martínez-Riaño et al., p. 3355

01 Nov 2023·Journal for ImmunoTherapy of Cancer

Systemic infusion of TLR3-ligand and IFN-α in patients with breast cancer reprograms local tumor microenvironments for selective CTL influx

Article

Author: Witkiewicz, Agnieszka ; Tarquini, Mary Lynne ; Williams, Lauren ; Kokolus, Kathleen M ; Grimm, Melissa J ; Early, Amy P ; Kalinski, Pawel ; Slomba, Ronald T ; Opyrchal, Mateusz ; Minderman, Hans ; Soh, Kah Teong ; Levine, Ellis G ; Gandhi, Shipra ; Groman, Adrienne ; Wallace, Paul K ; Attwood, Kristopher ; Maguire, Orla ; O'Connor, Tracey L

BackgroundPresence of cytotoxic T lymphocytes (CTL) in the tumor microenvironment (TME) predicts the effectiveness of cancer immunotherapies. The ability of toll-like receptor 3 (TLR3) ligands, interferons (IFNs) and COX2 inhibitors to synergistically induce CTL-attracting chemokines (but not regulatory T cell (Treg)-attractants) in the TME, but not in healthy tissues, observed in our preclinical studies, suggested that their systemic application can reprogram local TMEs.MethodsSix evaluable patients (33–69 years) with metastatic triple-negative breast cancer received six doses of systemic chemokine-modulating (CKM) regimen composed of TLR3 ligand (rintatolimod; 200 mg; intravenous), IFN-α2b (20 MU/m2; intravenous) and COX2 inhibitor (celecoxib; 2×200 mg; oral) over 2 weeks. The predetermined primary endpoint was the intratumoral change in the expression of CTL marker, CD8α, in the post-CKM versus pre-CKM tumor biopsies. Patients received follow-up pembrolizumab (200 mg, intravenously, every 3 weeks), starting 3–8 days after completion of CKM.ResultsPost-CKM biopsies showed selectively increased CTL markers CD8α (average 10.2-fold, median 5.5-fold, p=0.034) and granzyme B (GZMB; 6.1-fold, median 5.8-fold, p=0.02), but not FOXP3 (Treg marker) relative to HPRT1 expression, resulting in the increases in average CD8α/FOXP3 ratio and GZMB/FOXP3 ratio. CKM increased intratumoral CTL-attractants CCL5 and CXCL10, but not Treg-attractants CCL22 or CXCL12. In contrast, CD8+T cells and their CXCR3+subset showed transient decreases in blood. One clinical response (breast tumor autoamputation) and three stable diseases were observed. The patient with clinical response remains disease free, with a follow-up of 46 months as of data cut-off.ConclusionsShort-term systemic CKM selectively increases CTL numbers and CTL/Treg ratios in the TME, while transiently decreasing CTL numbers in the blood. Transient effects of CKM suggest that its simultaneous application with checkpoint blockade and other forms of immunotherapy may be needed for optimal outcomes.

03 Jul 2023·Expert Opinion on Investigational Drugs

Experimental drugs in randomized controlled trials for long-COVID: what’s in the pipeline? A systematic and critical review

Review

Author: Alwashmi, Ameen S S ; Alfaresi, Mubarak ; Albayat, Hawra ; Alsalman, Jameela ; Al Fares, Mona A ; Alfaraj, Amal H ; Halim, Michael ; AlShehail, Bashayer M ; Khamis, Faryal ; Alsanad, Ahlam H ; Dhama, Kuldeep ; Garout, Mohammed ; Alissa, Mohammed ; Al Kaabi, Nawal A ; Halim, Alice ; Alhajri, Mashael ; Sulaiman, Tarek ; Yong, Shin Jie ; Ming, Long Chiau ; Alburaiky, Lamees M ; Alsalem, Zainab ; Rabaan, Ali A ; Goh, Khang Wen ; AlShurbaji, Abdelmunim T ; Alsheheri, Ahmed

INTRODUCTIONOver three years have passed since the emergence of coronavirus disease 2019 (COVID-19), and yet the treatment for long-COVID, a post-COVID-19 syndrome, remains long overdue. Currently, there is no standardized treatment available for long-COVID, primarily due to the lack of funding for post-acute infection syndromes (PAIS). Nevertheless, the past few years have seen a renewed interest in long-COVID research, with billions of dollars allocated for this purpose. As a result, multiple randomized controlled trials (RCTs) have been funded in the quest to find an effective treatment for long-COVID.AREAS COVEREDThis systematic review identified and evaluated the potential of current drug treatments for long-COVID, examining both completed and ongoing RCTs.EXPERT OPINIONWe identified four completed and 22 ongoing RCTs, investigating 22 unique drugs. However, most drugs were deemed to not have high potential for treating long-COVID, according to three pre-specified domains, a testament to the ordeal of treating long-COVID. Given that long-COVID is highly multifaceted with several proposed subtypes, treatments likely need to be tailored accordingly. Currently, rintatolimod appears to have modest to high potential for treating the myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) subtype, LTY-100 and Treamid for pulmonary fibrosis subtype, and metformin for general long-COVID prevention.

117

News (Medical) associated with Rintatolimod

03 Oct 2024

·www.globenewswire.com

AIM ImmunoTech Granted U.S. Patent for Ampligen® for the Treatment of Endometriosis

OCALA, Fla., Oct. 03, 2024 (GLOBE NEWSWIRE) -- AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM” or the “Company”) today announced that the United States Patent and Trademark Office (USPTO) has granted U.S. patent No. 12,102,649, covering both compositions and methods comprising the Company’s drug Ampligen® in the treatment of endometriosis, a painful chronic condition that affects nearly 10% of women of reproductive age, or approximately 6.5 million women in the United States. Endometriosis is a disease in which tissue similar to the lining of the uterus grows outside the uterus, causing severe pelvic pain and making it difficult or impossible to become pregnant. It can cause inflammation and infertility, and symptoms such as intense menstrual cramps, severe pelvic pain and chronic fatigue, all of which can significantly impact quality of life. Despite its prevalence, treatment options are limited, and many women experience years of misdiagnosis. The patented method involves the administration of a therapeutically effective amount of a pharmaceutical composition containing AIM’s proprietary double-stranded RNA products. The patent’s claims describe a unique class of therapeutic double-stranded RNAs (e.g., tdsRNA, Ampligen®, rugged dsRNA) which are key components in these potentially groundbreaking treatment methods and compositions. The versatile administration options offer flexibility for patient-specific needs and care. The patent also covers treatments targeting recurrent endometriosis and includes options for co-administration with interferons, including well-known types such as alpha and beta interferons. Patients with endometriosis also are at more than four times the risk of developing ovarian cancer than are people without endometriosis, according to a recent article in JAMA. As we have previously announced, Ampligen has also shown positive results as part of a combination therapy in the treatment of advanced recurrent ovarian cancer. Read more: “AIM ImmunoTech Announces Positive Top-Line, Protocol-Planned Interim Report Data from the Study of Ampligen Combined with Pembrolizumab for the Treatment of Recurrent Ovarian Cancer” Robert Edwards, MD, a world-renowned expert in women’s reproductive health and Chair of Ob/Gyn/RS at the University of Pittsburgh Medical Center, Magee-Womens Hospital, stated: “Endometriosis is a chronic disease that threatens the fertility and wellbeing of greater than 10% of the population, but total incidence is not known. Effective treatment now involves some form of estrogen deprivation or surgery, both of which have serious side effects and fertility risks themselves. A medical therapy that relieves symptoms and abates the inflammatory response would be a significant breakthrough in treatment options. At UPMC we have conducted an extensive clinical evaluation of Ampligen in recurrent ovarian cancer with positive results. Ampligen’s safety profile is well developed and Ampligen has been generally well tolerated.” AIM Chief Executive Officer Thomas K. Equels commented, "This patent is a significant milestone for AIM, not only strengthening our intellectual property portfolio, but also expanding our potential to provide life-changing therapies for women suffering from endometriosis. With the global focus on women's health, we are excited about the possibilities this new treatment presents. At AIM, our goal is to make a difference by improving the quality of life for women suffering from endometriosis." About AIM ImmunoTech Inc. AIM ImmunoTech Inc. is an immuno-pharma company focused on the research and development of therapeutics to treat multiple types of cancers, immune disorders and viral diseases, including COVID-19. The Company’s lead product is a first-in-class investigational drug called Ampligen® (rintatolimod), a dsRNA and highly selective TLR3 agonist immuno-modulator with broad spectrum activity in clinical trials for globally important cancers, viral diseases and disorders of the immune system. For more information, please visit aimimmuno.com and connect with the Company on X, LinkedIn, and Facebook. Cautionary Statement This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 (the “PSLRA”). Words such as “may,” “will,” “expect,” “plan,” “anticipate,” “continue,” “believe,” “potential,” “upcoming” and other variations thereon and similar expressions (as well as other words or expressions referencing future events or circumstances) are intended to identify forward-looking statements. Many of these forward-looking statements involve a number of risks and uncertainties. Data, pre-clinical success and clinical success seen to date does not guarantee that Ampligen will be approved as a therapy for endometriosis or ovarian cancer. The Company urges investors to consider specifically the various risk factors identified in its most recent Form 10-K, and any risk factors or cautionary statements included in any subsequent Form 10-Q or Form 8-K, filed with the U.S. Securities and Exchange Commission. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Among other things, for those statements, the Company claims the protection of the safe harbor for forward-looking statements contained in the PSLRA. The Company does not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof. Photos accompanying this announcement are available at: https://www.globenewswire.com/NewsRoom/AttachmentNg/b3aac790-f746-4dac-afe7-796d4ce31897 https://www.globenewswire.com/NewsRoom/AttachmentNg/c697332b-3cca-4968-8f85-b1a98a8882bd

ImmunotherapysiRNA

27 Sep 2024

·www.globenewswire.com

AIM ImmunoTech to Participate in Virtual Investor CEO Connect Segment

Live video webcast with Tom Equels, Chief Executive Officer of AIM ImmunoTech, on Wednesday, October 2nd at 4:00 PM ETOCALA, Fla., Sept. 27, 2024 (GLOBE NEWSWIRE) -- AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM” or the “Company”) today announced that Thomas K. Equels, Chief Executive Officer of AIM will participate in a Virtual Investor CEO Connect segment on Wednesday, October 2, 2024 at 4:00 PM ET. As part of the event, Mr. Equels will provide a brief presentation, followed by an interactive Q&A session. Investors and interested parties will have the opportunity to submit questions live during the event. Questions can also be pre-submitted leading up to the event by emailing AIM@jtcir.com. Mr. Equels will answer as many questions as possible in the time allowed. A live video webcast of the presentation will be available on the Events page of the Company’s website (aimimmuno.com). A webcast replay will be available two hours following the live presentation and will be accessible for 90 days. About AIM ImmunoTech Inc. AIM ImmunoTech Inc. is an immuno-pharma company focused on the research and development of therapeutics to treat multiple types of cancers, immune disorders and viral diseases, including COVID-19. The Company’s lead product is a first-in-class investigational drug called Ampligen® (rintatolimod), a dsRNA and highly selective TLR3 agonist immuno-modulator with broad spectrum activity in clinical trials for globally important cancers, viral diseases and disorders of the immune system. For more information, please visit aimimmuno.com and connect with the Company on X, LinkedIn, and Facebook.

Immunotherapy

19 Sep 2024

·www.globenewswire.com

AIM ImmunoTech Reports Positive Preliminary Data in Phase 1b/2 Study of Ampligen and Imfinzi as a Combination Therapy for Late-Stage Pancreatic Cancer

Preliminary finding of stable disease in two out of three patients at 6 months in the first subject cohort Combination of Ampligen and Imfinzi continues to be generally well-tolerated with no severe adverse events or dose-limiting toxicities OCALA, Fla., Sept. 19, 2024 (GLOBE NEWSWIRE) -- AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM”) today announced positive preliminary data from the Phase 1b/2 study (“DURIPANC”) evaluating the combination of AIM’s Ampligen® (rintatolimod) and AstraZeneca’s anti-PD-L1 immune checkpoint inhibitor Imfinzi® (durvalumab) in the treatment of late-stage pancreatic cancer. DURIPANC is an investigator-initiated, exploratory, open-label, single-center study. AIM previously announced that investigators at Erasmus Medical Center (“Erasmus MC”) in the Netherlands had completed the safety evaluation of subjects enrolled in the first dose level of the dose escalation design, finding the combination therapy to be generally well-tolerated with no severe adverse events or dose-limiting toxicities. That first cohort has now reached the pre-determined 6-month stability assessment timepoint and AIM is pleased to announce that two of the three subjects remain stable. The subjects will continue to be treated and receive formal assessment of progression every three months. The standard for calculating median progression-free survival (“PFS”) requires that 50% or more of the subjects have seen disease progression. Because 67% of the patients in the cohort evaluated at 6 months have remained stable, AIM cannot yet report on PFS. Two of the three subjects in the higher-dose second cohort of subjects also have stable disease, although they have not yet reached the 6-month stability assessment timepoint. Investigators continue to treat and monitor these subjects. Prof. Casper H.J. van Eijck, MD, PhD, Pancreato-biliary Surgeon at Erasmus MC and Coordinating Investigator for the DURIPANC study, commented: “First of all, we have observed improvements in quality of life and we saw no toxicity at all — with ‘quality of life’ recognized as an indicator of stable disease. As a comparison, approximately 80% of patients at Erasmus with similar disease, but who did not receive the treatment, showed disease progression after only three months. While this new data is extremely preliminary, it is also highly encouraging. To have multiple patients with metastatic pancreatic cancer who still have stable disease after six or seven months of maintenance therapy is remarkable — as is having stable disease for 15 or more months after starting FOLFIRINOX. Based on the changes we have seen in immune infiltration into metastatic lesions, I am optimistic that there is a chance that these patients could still have partial or complete responses to this therapy.” “Ampligen continues to demonstrate its synergistic potential as a combination therapy with checkpoint inhibitors and these data — following the positive data from the Dutch-government approved Early Access Program — underscore Ampligen’s potential for the treatment of late-stage pancreatic cancer, where there remains a significant and lethal unmet need,” commented AIM Chief Executive Officer Thomas K. Equels. Read more at ClinicalTrials.gov NCT05927142 — “Combining anti-PD-L1 immune checkpoint inhibitor durvalumab with TLR-3 agonist rintatolimod in patients with metastatic pancreatic ductal adenocarcinoma for therapy effect” Learn more about the clinical collaboration between AIM, AstraZeneca and Erasmus MC. About AIM ImmunoTech Inc. AIM ImmunoTech Inc. is an immuno-pharma company focused on the research and development of therapeutics to treat multiple types of cancers, immune disorders and viral diseases, including COVID-19. The Company’s lead product is a first-in-class investigational drug called Ampligen® (rintatolimod), a dsRNA and highly selective TLR3 agonist immuno-modulator with broad spectrum activity in clinical trials for globally important cancers, viral diseases and disorders of the immune system. For more information, please visit aimimmuno.com and connect with the Company on X, LinkedIn, and Facebook. Cautionary Statement This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 (the “PSLRA”). Words such as “may,” “will,” “expect,” “plan,” “anticipate,” “continue,” “believe,” “potential,” “upcoming” and other variations thereon and similar expressions (as well as other words or expressions referencing future events or circumstances) are intended to identify forward-looking statements. Many of these forward-looking statements involve a number of risks and uncertainties. Data, pre-clinical success and clinical success seen to date does not guarantee that Ampligen will be approved as a combination therapy for late-stage pancreatic cancer. The Company urges investors to consider specifically the various risk factors identified in its most recent Form 10-K, and any risk factors or cautionary statements included in any subsequent Form 10-Q or Form 8-K, filed with the U.S. Securities and Exchange Commission. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Among other things, for those statements, the Company claims the protection of the safe harbor for forward-looking statements contained in the PSLRA. The Company does not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof.

ImmunotherapyClinical ResultClinical Study

100 Deals associated with Rintatolimod

External Link

KEGG	Wiki	ATC	Drug Bank
D09661	Rintatolimod	L03A	-

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Fatigue Syndrome, Chronic	AR	AIM ImmunoTech, Inc.	01 Jan 2017

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Locally Advanced Pancreatic Adenocarcinoma	Phase 2	US	AIM ImmunoTech, Inc.	01 Oct 2024
Metastatic Pancreatic Ductal Adenocarcinoma	Phase 2	NL	AIM ImmunoTech, Inc.	09 Jan 2024
Secondary malignant neoplasm of pancreas	Phase 2	NL	AIM ImmunoTech, Inc.	09 Jan 2024
Post Acute COVID 19 Syndrome	Phase 2	US	AIM ImmunoTech, Inc.	30 Jun 2023
Colorectal Cancer	Phase 2	-	AIM ImmunoTech, Inc.	11 Apr 2022
Triple Negative Breast Cancer	Phase 1	US	AIM ImmunoTech, Inc.	11 Apr 2022
Adenocarcinoma of prostate	Preclinical	US	AIM ImmunoTech, Inc.	29 Nov 2019
Prostate Cancer, Hereditary, 7	Preclinical	US	AIM ImmunoTech, Inc.	29 Nov 2019
HIV Seropositivity	Preclinical	US	AIM ImmunoTech, Inc.	01 May 2001
Fatigue Syndrome, Chronic	Preclinical	-	AIM ImmunoTech, Inc.	01 Dec 1998

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05592418 (AMP-518, Corporate Publications) Manual	Phase 2	Post Acute COVID 19 Syndrome	66	Ampligen	(nemmjgtcyl) = between the Ampligen and placebo groups reached or approached statistical significance at several timepoints during the treatment phase. rdoqnhpjme (aankcryzso ) View more	Positive	08 Feb 2024
NCT05592418 (AMP-518, Corporate Publications) Manual	Phase 2	Post Acute COVID 19 Syndrome	66	Placebo		Positive	08 Feb 2024
NCT03734692 (GlobeNewswire) Manual	Phase 2	Recurrent ovarian cancer	-	Ampligen+pembrolizumab	dzvegdgnyw(mppcfeeinu) = Longitudinal comparison of biomarkers in tumor microenvironment showed a gradual, durable response over time in T lymphotactic CXCR3 ligands and cytolytic factors ogwthrnjpb (qiywupvexe )	Positive	08 Nov 2023
Corporate Publications Manual	Phase 1	-	40	Rintatolimod	gcfveqocxi(iekcrnvtwc) = qavebzwrkc gviulrowsu (uovkhedfmf )	Positive	08 Dec 2022
Corporate Publications Manual	Phase 1	-	40	Placebo	gcfveqocxi(iekcrnvtwc) = cooecaghjv gviulrowsu (uovkhedfmf )	Positive	08 Dec 2022
NCT04081389 (SITC2022) Manual	Phase 1	Triple Negative Breast Cancer ER Negative \| HER2 Negative \| PR Negative	9	celecoxib+interferon (IFN)-α2b+rintatolimod	(dsatsiorzi) = dhcynscrys kupxiolpjq (wtedayrgcm ) View more	Positive	01 Nov 2022
NCT03403634 (AACR2022) Manual	Phase 2	Colorectal Liver Metastases Microsatellite Stable (MSS)	12	celecoxib+IFNα2b IV+rintatolimod	fhzmelolxx(ateizssmap) = increased lnlfzjcttj (ocvypomiik ) Met View more	Positive	15 Jun 2022
NCT03599453 (AACR2022)	Early Phase 1	Metastatic Triple-Negative Breast Carcinoma	6	Systemic rintatolimod and interferon-α2b	edbgbrplxj(lpxjbjambl) = yiehotxbuz rxdykwwjkk (bztvomiqck ) View more	-	15 Jun 2022
NCT03599453 (GlobeNewswire) Manual	Phase 1	Metastatic Triple-Negative Breast Carcinoma Triple Negative	6	IFN-2+Celecoxib+Ampligen+Pembrolizumab	pttfrggoqw(dwooxonirl) = jnlyjslbwx hmyeraecxw (lgjizandmj ) View more	Positive	11 Apr 2022
NCT03734692 (Biospace) Manual	Phase 2	Ovarian Cancer	17	Cisplatin+Rintatolimod+Pembrolizumab	(dfdmwexevn) = adjohimgwe mcwmnkflzk (sshtithtnu ) View more	Positive	09 Mar 2022
Pubmed \| Cancers (Basel) Manual	Not Applicable	Pancreatic Cancer	81	FOLFIRINOX+Rintatolimod	(jypbsrhsvb) = rhamddqziw fksqadjrxm (dhwygsfezk ) View more	Positive	08 Mar 2022
Pubmed \| Cancers (Basel) Manual	Not Applicable	Pancreatic Cancer	81	FOLFIRINOX+Placebo	(jypbsrhsvb) = vgmlmbqadz fksqadjrxm (dhwygsfezk ) View more	Positive	08 Mar 2022
NCT03403634 (CTgov)	Phase 2	Liver metastases \| Colorectal cancer recurrent \| Colorectal Cancer	19	Laboratory Biomarker Analysis+Intron A+Heberon Alfa+Urifron+Rintatolimod+Celecoxib	qgucmosxad(ikqcknrrfe) = zlynqehlbh unaqpwkxfy (ptuzxdkwud, xyschpwjuo - lbvygkartz) View more	-	02 Mar 2022

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