Drug Type Small molecule drug |
Synonyms Ampligen, Atvogen, Rintamod + [5] |
Target |
Mechanism TLR3 agonists(Toll like receptor 3 agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date AR (01 Jan 2017), |
RegulationFast Track (US), Orphan Drug (US), Orphan Drug (EU) |
Molecular FormulaC28H40N9O25P3 |
InChIKeyKNUXHTWUIVMBBY-JRJYXWDASA-N |
CAS Registry38640-92-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D09661 | Rintatolimod | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Fatigue Syndrome, Chronic | AR | 01 Jan 2017 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Refractory Melanoma | Phase 2 | US | 20 Jun 2024 | |
Locally Advanced Pancreatic Adenocarcinoma | Phase 2 | US | 01 May 2024 | |
Metastatic Pancreatic Ductal Adenocarcinoma | Phase 2 | NL | 09 Jan 2024 | |
Secondary malignant neoplasm of pancreas | Phase 2 | NL | 09 Jan 2024 | |
Post Acute COVID 19 Syndrome | Phase 2 | US | 30 Jun 2023 | |
Colorectal Cancer, Hereditary Nonpolyposis, Type 1 | Phase 2 | US | 01 Feb 2022 | |
Metastatic Colorectal Carcinoma | Phase 2 | US | 01 Feb 2022 | |
Refractory Colorectal Carcinoma | Phase 2 | US | 01 Feb 2022 | |
Turcot Syndrome | Phase 2 | US | 01 Feb 2022 | |
Unresectable Colorectal Carcinoma | Phase 2 | US | 01 Feb 2022 |
Phase 2 | Locally Advanced Pancreatic Adenocarcinoma Maintenance | 90 | nzltkrjwzg(govbzohfxv) = zpeyxixpaq hiebwdywwj (rftxocmnay ) View more | Positive | 24 May 2024 | ||
Phase 2 | 66 | nhekcwvppt(ccpbfauvpb) = between the Ampligen and placebo groups reached or approached statistical significance at several timepoints during the treatment phase. pwhirnqptv (yynajposnl ) View more | Positive | 08 Feb 2024 | |||
Placebo | |||||||
Phase 2 | - | wawyesrfit(vlaibqjcog) = Longitudinal comparison of biomarkers in tumor microenvironment showed a gradual, durable response over time in T lymphotactic CXCR3 ligands and cytolytic factors pcogrkgrqo (ecuxajwujk ) | Positive | 08 Nov 2023 | |||
Phase 1 | 9 | Interferon Alpha-2b (Arm 1: Interferon Alpha-2b at DL 1) | vyhrngjjzv(pxgjhgdgfu) = flhxayricu pgcilymhpg (qmwvtcrpnw, yxiwhuiwex - lvpelzzibq) View more | - | 11 Sep 2023 | ||
Interferon Alpha-2b (Arm 2: Interferon Alpha-2b at DL 2) | vyhrngjjzv(pxgjhgdgfu) = wmrhihtiai pgcilymhpg (qmwvtcrpnw, pfllqsxkxe - rybxwxmjbh) View more | ||||||
Corporate Publications Manual | Phase 1 | - | 40 | jwmekmsydh(hvrysspnbg) = ntzzfkjtbl qugjbhgcqq (gxpzpkqhuu ) | Positive | 08 Dec 2022 | |
Placebo | jwmekmsydh(hvrysspnbg) = rjaopjadiz qugjbhgcqq (gxpzpkqhuu ) | ||||||
NCT04081389 (SITC2022) Manual | Phase 1 | Triple Negative Breast Cancer ER Negative | HER2 Negative | PR Negative | 9 | lsihgipxkb(isutzhragq) = jglwjiwjat uavffcrfzo (rngjnyydkb ) View more | Positive | 01 Nov 2022 | |
Not Applicable | 4 | tsqaeevcpu(wwlnvnjpsp) = The preliminary data from this uncontrolled clinical trial found that patients reported statistically significant improvements in chronic fatigue after treatment with Ampligen xmeewaynmo (zuydpptlmo ) | Positive | 28 Jul 2022 | |||
NCT03403634 (AACR2022) Manual | Phase 2 | Colorectal Liver Metastases Microsatellite Stable (MSS) | 12 | vonfzcqdpa(skpbasskym) = increased ijbjozkzzq (zphwiphlku ) Met View more | Positive | 15 Jun 2022 | |
Early Phase 1 | 6 | Systemic rintatolimod and interferon-α2b | oreobklktc(qjcwgdpxau) = urcgeaovwf knjmhsxktq (snuyuuxoyx ) View more | - | 15 Jun 2022 | ||
Phase 1 | Metastatic Triple-Negative Breast Carcinoma Triple Negative | 6 | nlqykawzon(rotnmlvskw) = roqtpxctpj uiamaunilv (dxeuenbqim ) View more | Positive | 11 Apr 2022 |