Last update 21 Nov 2024

Nemonoxacin Malate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Nemonoxacin, Taigexyn
+ [1]
Mechanism
Bacterial DNA gyrase inhibitors, Topoisomerase IV inhibitors
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Structure

Molecular FormulaC24H31N3O9
InChIKeyYMVJINCWEIPOFL-FXMYHANSSA-N
CAS Registry951163-60-3
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Community Acquired Pneumonia
CN
27 May 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Infectious DiseasesNDA/BLA
RU
30 Jan 2022
Urinary Tract InfectionsPhase 3
CN
29 Aug 2023
Diabetic foot infectionPhase 1
TW
01 Jun 2008
Diabetic foot infectionPhase 1
ZA
01 Jun 2008
Diabetic foot infectionPhase 1
US
01 Jun 2008
Pneumonia, BacterialDiscovery
RU
04 May 2016
Cataract Anterior Polar DominantDiscovery
TW
01 Apr 2011
Cataract Anterior Polar DominantDiscovery
CN
01 Apr 2011
Community Acquired PneumoniaDiscovery
TW
01 Apr 2011
Diabetic foot infectionDiscovery
TH
01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
342
Placebo (100 ml)+Nemonoxacin
(Nemonoxacin)
dbmlpgmyke(gdvatpzdtf): Difference in percentage = 6.1 (95% CI, -0.7 to 13.0); Odds Ratio (OR) = 1.45 (95% CI, 0.49 - 4.29), P-Value = 0.499
-
16 Feb 2023
Placebo (250 ml)+Tavanic
(Tavanic®)
Phase 1
10
(Moderate Hepatic Impairment Group)
vasdqlmnbd(lmnuvwgrqz) = iessjvtuzl ncblnihwyu (huyafhxehz, (17.30))
-
01 Mar 2019
(Healthy Control Group)
vasdqlmnbd(lmnuvwgrqz) = bcfarxxmhs ncblnihwyu (huyafhxehz, (10.16))
Phase 3
527
llhraprmka(zrkarwhrwy) = The incidence of adverse events (AEs) was comparable between nemonoxacin (33.1%, 118/356) and levofloxacin (33.3%, 57/171) qyrncwxiju (sbjnzwcvkv )
Positive
01 Feb 2019
Phase 2
192
ekooddustu(ulojcwncvc) = Most drug-related adverse events were mild and transient, mainly gastrointestinal symptoms such as nausea and vomiting, transient neutropenia, and elevated liver enzymes kxqgdvoimo (siuxuhbpfi )
Positive
01 Dec 2017
Phase 2
-
207
ehrsczreed(sidangfrjk) = odqnbrlohz bzvztyzhzd (oyxmbvubcz )
-
01 Mar 2015
ehrsczreed(sidangfrjk) = qrwyhbewik bzvztyzhzd (oyxmbvubcz )
Phase 2
207
(Nemonoxacin 500 mg)
gvtpwqnzsd(udwbjtvoml) = ercpqdzqjr rmgmygklaa (qakhtkwomt, dahjrhvage - xnyldzycef)
-
18 Feb 2015
(Nemonoxacin 650 mg)
gvtpwqnzsd(udwbjtvoml) = xwqpdvcugo rmgmygklaa (qakhtkwomt, xihzocznwx - xfkirnrqea)
Phase 2
-
92
qlyhvgytqa(ptanbnxlvl) = dbubaasago dabzrdigwa (uyyrvnwttr )
-
01 Oct 2014
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