Delving into the Latest Updates on Diclofenac Sodium/Menthol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Diclofenac-menthol, Diclofenac/menthol, Menthol/diclofenac

+ [2]

Target

COX x TRPA1 x TRPM8

Mechanism

COX inhibitors(Cyclooxygenases inhibitors), TRPA1 agonists(Transient receptor potential cation channel subfamily A member 1 agonists), TRPM8 agonists(Transient receptor potential cation channel subfamily M member 8 agonists)

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication-

Inactive Indication

Ankle InjuriesPain

Originator Organization

GSK Plc

Active Organization-

Inactive Organization

GSK Plc

Drug Highest PhasePendingPhase 3

First Approval Date-

Regulation-

Login to view timeline

Structure

Molecular FormulaC10H20O

InChIKeyNOOLISFMXDJSKH-KXUCPTDWSA-N

CAS Registry89-78-1

View All Structures (2)

This research study is being carried out to determine the possibility that a new medication causes allergic reactions. This new medication contains two active ingredients (diclofenac and menthol) together in a gel and is being developed to treat mild to moderate pain and inflammation, such as acute sport injuries, and sprains and strains. Approximately 240 participants will have the medication (gel) applied to the skin on a small area of the upper back for approximately 48-hour or 72-hour periods over the course of six weeks. Participation in this research study is voluntary, requiring participants to visit the study clinic on 17 occasions for about 45 minutes each visit. During the visits, doctors or trained staff members will examine the amount of redness, swelling, and other signs of irritation (if any) of the skin where the medication (gel) was applied.

Start Date01 Apr 2014

Sponsor / Collaborator

GSK Plc

NCT02100670 / CompletedPhase 3

A Clinical Study to Assess the Efficacy and Onset of Pain Relief of Topical MFC51123 Diclofenac-Menthol Gel Versus Controls in Ankle Sprain

This Phase III pivotal efficacy study will assess efficacy and onset of pain relief of MFC51123 gel vs. placebo and MFC51123 gel vs. 1% diclofenac gel and 3% menthol gel in participants with an ankle sprain to support topical MFC51123 gel registration.

Start Date01 Nov 2013

Sponsor / Collaborator

GSK Plc

100 Clinical Results associated with Diclofenac Sodium/Menthol

Login to view more data

100 Translational Medicine associated with Diclofenac Sodium/Menthol

Login to view more data

100 Patents (Medical) associated with Diclofenac Sodium/Menthol

Login to view more data

3

Literatures (Medical) associated with Diclofenac Sodium/Menthol

01 Feb 2024·Science of The Total Environment

A contrast of emerging contaminants rac- and l-menthol toxicities to Microcystis aeruginosa through biochemical, physiological, and morphological investigations

Article

Author: Ye, Jing ; Feng, Chenglian ; Wu, Fengchang ; Yu, Xinyue ; Wu, Liang ; Wang, Chen

Fragrances rac- and l-menthol extracted from peppermint are widely used and considered as emerging contaminants recently, which are persistent in the environment. Menthol has always been considered as a safe chemical for humans, but its potential adverse ecological effects on aquatic organisms and the toxic mechanisms have not yet been fully understood. The present study aims to investigate the physiological response of Microcystis aeruginosa after exposure to the two menthol isomers, and to explore the toxic mechanisms and ecological risks of these two chemicals. Results showed that rac-menthol exhibited a hormesis effect on the cell growth, chlorophyll a and protein contents; while l-menthol showed an inhibition effect. Adenosine triphosphate (ATP) content increased significantly at day 3 and then decreased markedly at day 6 after exposure to the two chemicals. Compared with rac-menthol, l-menthol can cause damage to the antioxidant system and plasmalemma more severely, promote the production and release of microcystins-LR (MC-LR) more dramatically, upregulate the expression of MC-transportation-related gene mcyH, and induce higher apoptosis rates. Overall results revealed that the toxic effects of l-menthol on cyanobacteria were significantly greater than those of rac-menthol. The significant increase in the malondialdehyde (MDA) content and the ultrastructural characteristics of the cells indicated that the plasma membranes were damaged. Thus, further attention should be paid to the scientific use, ecological and environmental risk assessment of chiral menthol. This study will also provide a scientific basis for future water quality criteria establishment on emerging contaminants such as fragrances.

01 May 2018·Iranian journal of medical sciences

Delayed Complications and Long-Term Management of Sulfur Mustard Poisoning: A Narrative Review of Recent Advances by Iranian Researchers Part ІІ: Clinical Management and Therapy.

Review

Author: Mohammad Moshiri ; Leila Etemad ; Mahdi Balali-Mood

The present study aimed to review and discuss the recommended and recently suggested protocols by Iranian researchers for a long-term treatment of delayed complications of sulfur mustard (DCSM) in veterans. As indicated clinically, patients who suffer from delayed ocular complications of sulfur mustard (DOCS) benefit from treatments for dry eyes, therapeutic contact lenses, amniotic membrane transplantation; blepharorrhaphy, tarsorrhaphy, limbal stem cell transplantation; corneal transplantation, topical steroids, and immunosuppressive. In spite of penetrating keratoplasty, lamellar keratoplasty and keratolimbal allograft had a good long-term survival. Delayed respiratory complications (DRCS) are the most common effects and life-threatening in Iranian veterans. The recommended treatment protocols include regular clinical evaluations, respiratory physiotherapy and rehabilitation, N-acetyl cysteine; warm humidified air, long-acting b2-agonists, and inhaled corticosteroids. Azithromycin has also been effective in improving clinical conditions, pulmonary function tests, inflammatory indexes, and life quality of the veterans. Interferon gamma (IFN-γ) and helium: oxygen combination were also used in severe DRCS with good results. Some of the delayed cutaneous complications (DCCS) such as itching affects the quality of life of victims. Regular but not frequent showering and bathing, applying sunscreen compounds, topical corticosteroids, and systemic antihistamines reduce the problems of DCCS patients. Several compounds such as capsaicin cream, pimecrolimus, IFN-γ, phenol-menthol; Aloe vera/olive oil cream, cetirizine, doxepine, and hydroxyzine were evaluated in DCCS patients with some benefits. The physicians in charge of veterans emphasize the importance of a healthy lifestyle, appropriate financial/social/cultural supports, and a degree of reassurance and supportive care on the clinical improvement of patients.

01 Aug 2011·Journal of Sport RehabilitationQ4 · MEDICINE

Comparison of the Effects of Ice and 3.5% Menthol Gel on Blood Flow and Muscle Strength of the Lower Arm

Q4 · MEDICINE

Article

Author: Topp, Robert ; Kaufman, Jeremiah S ; Winchester, Lee ; Jacks, Dean E ; Mink, Amber M

Context:Soft-tissue injuries are commonly treated with ice or menthol gels. Few studies have compared the effects of these treatments on blood flow and muscle strength.Objective:To compare blood flow and muscle strength in the forearm after an application of ice or menthol gel or no treatment.Design:Repeated-measures design in which blood-flow and muscle-strength data were collected from subjects under 3 treatment conditions.Setting:Exercise physiology laboratory.Participants:17 healthy adults with no impediment to the blood flow or strength in their right arm, recruited through word of mouth.Intervention:Three separate treatment conditions were randomly applied topically to the right forearm: no treatment, 0.5 kg of ice, or 3.5 mL of 3.5% menthol gel. To avoid injury ice was only applied for 20 min.Main Outcome Measures:At each data-collection session blood flow (mL/min) of the right radial artery was determined at baseline before any treatment and then at 5, 10, 15, and 20 min after treatment using Doppler ultrasound. Muscle strength was assessed as maximum isokinetic flexion and extension of the wrist at 30°/s 20, 25, and 30 min after treatment.Results:The menthol gel reduced (−42%, P < .05) blood flow in the radial artery 5 min after application but not at 10, 15, or 20 min after application. Ice reduced (−48%, P < .05) blood flow in the radial artery only after 20 min of application. After 15 min of the control condition blood flow increased (83%, P < .05) from baseline measures. After the removal of ice, wrist-extension strength did not increase per repeated strength assessment as it did during the control condition (9−11%, P < .05) and menthol-gel intervention (8%, P < .05).Conclusions:Menthol has a fast-acting, short-lived effect of reducing blood flow. Ice reduces blood flow after a prolonged duration. Muscle strength appears to be inhibited after ice application.

100 Deals associated with Diclofenac Sodium/Menthol

Login to view more data

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Ankle Injuries	Phase 3	DE	GSK Plc	01 Nov 2013
Pain	Phase 3	DE	GSK Plc	01 Nov 2013

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02100670 (CTgov)	Phase 3	Pain \| Ankle Injuries	385	3% menthol (3% Menthol)	tsxyvgyoeb(xtdbqygwie) = koxcvxsbwt hsxhiikfxy (qtwibfztyu, ksrgkdvzrt - aftdtulqec) View more	-	12 Jan 2018
				1% diclofenac sodium plus 3% menthol (1% Diclofenac Sodium Plus 3% Menthol)	cpkjhkonfi(aktgfpoqtq) = ktegfenhtn vuthyxgero (vxkgrgxjsd, twjbblwawn - kkbipgriuc) View more