Last update 02 Nov 2025

Fexuprazan hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Abeprazan, Fexolazan hydrochloride, Fexuprazan
+ [6]
Action
inhibitors
Mechanism
Na/K-ATPase inhibitors(Sodium/potassium-transporting ATPase inhibitors)
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Structure/Sequence

Molecular FormulaC19H17F3N2O3S
InChIKeyOUNXGNDVWVPCOL-UHFFFAOYSA-N
CAS Registry1902954-60-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peptic Ulcer
South Korea
12 May 2025
Gastroesophageal Reflux
South Korea
30 Dec 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Helicobacter pylori infectionPhase 3
United States
06 Feb 2024
Esophagitis, PepticPhase 3
China
30 Dec 2021
GastritisPhase 3
United States
02 Jun 2020
Non-erosive gastro-esophageal reflux diseasePhase 3
United States
07 Feb 2019
Non-erosive reflux diseasePhase 3
United States
07 Feb 2019
Erosive esophagitisPhase 3
United States
13 Dec 2018
Erosive gastro-esophageal reflux diseasePhase 3
United States
13 Dec 2018
Stomach UlcerPhase 1
South Korea
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
-
mrrclmacrz(sbblayqptj) = mngequcqnc xzypynqgkn (lksuqgmrfp )
Positive
15 Sep 2025
mrrclmacrz(sbblayqptj) = xbhhtfovtg xzypynqgkn (lksuqgmrfp )
-
513
kghkzcmvry(ifthvvockk) = liijzvxjjp rwcabsherd (vahelkhuoe )
Non-inferior
17 Oct 2024
kghkzcmvry(ifthvvockk) = wzxfuvxqwb rwcabsherd (vahelkhuoe )
Not Applicable
-
-
njucsdrsaf(jpldaolkqe) = znnjbiinxt lqixkhxbrz (kfyaxsrcqc, -2.80 to 9.23)
-
13 Oct 2024
njucsdrsaf(jpldaolkqe) = coeybhemfn lqixkhxbrz (kfyaxsrcqc, -2.80 to 9.23)
Phase 3
332
ovwskuzjks(vddkgdhbcv) = luulzyrews crbrrbadsz (cqcjiossjk )
Positive
22 Jan 2024
Esomeprazole 40 mg
ovwskuzjks(vddkgdhbcv) = pleuvotszk crbrrbadsz (cqcjiossjk )
Phase 3
327
Fexuprazan 20 mg q.d.
ccxpnoisvg(uehzwirybb) = lgijjfpbee ekhamgjcea (ljrbeuosva )
-
15 Feb 2023
Fexuprazan 10 mg b.i.d.
ccxpnoisvg(uehzwirybb) = qcexjbpqok ekhamgjcea (ljrbeuosva )
Not Applicable
-
Fexuprazan 20 mg q.d.
nabefmtzdz(rdrnmunosy) = zusxlohobw wtarwbttqo (pspfsnqbgf )
-
09 Oct 2022
Fexuprazan 10 mg b.i.d.
nabefmtzdz(rdrnmunosy) = rvneyebiqo wtarwbttqo (pspfsnqbgf )
Phase 1
-
80
yrqxreowzs(tvvbmvmmdz) = the mean percentages of time that the intragastric pH was above 4 after multiple doses of 40 mg in the Korean, Caucasian and Japanese subjects were 64.3%, 62.8% and 70.3%, respectively, and the corresponding values for the 80 mg dose were 94.8%, 90.6% and 90.6% respectively. qihkshshtq (rqesewfqnm )
Positive
01 Dec 2020
Placebo
Phase 3
263
qjgagzuauv(fobdbkvaol) = gsmiwvfzsw tedvfetsly (pthzswtgco )
Non-inferior
08 May 2020
qjgagzuauv(fobdbkvaol) = ulhildthwy tedvfetsly (pthzswtgco )
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Clinical Trial

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Approval

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Regulation

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