Last update 19 Jul 2024

Esomeprazole Magnesium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(S)-(−)-omeprazole, (S)-omeprazole, (−)-omeprazole
+ [36]
Mechanism
Proton pump inhibitors
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC34H38MgN6O7S2
InChIKeyLGRFYKXKCZKDLS-UHFFFAOYSA-N
CAS Registry217087-09-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anastomotic ulcer
JP
15 Aug 2022
Esophagitis
US
03 Feb 2016
Helicobacter pylori infection
JP
21 Feb 2013
duodenal ulcer due to anti-platelet agent
JP
22 Jun 2012
Esophagitis, Peptic
AU
22 Dec 2010
Gastroduodenal disorder
AU
22 Dec 2010
Erosive esophagitis
US
20 Mar 2008
Zollinger-Ellison Syndrome
US
11 Oct 2006
Heartburn
US
20 Jun 2003
Stomach Ulcer
CN
16 Oct 2002
Duodenal Ulcer
US
20 Feb 2001
Gastroesophageal Reflux
US
20 Feb 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-erosive reflux diseasePhase 3
JP
01 Jun 2014
HemorrhagePhase 3
CN
26 Feb 2013
Upper gastrointestinal hemorrhagePhase 3
CN
01 Aug 2006
Peptic Ulcer HemorrhagePhase 3
AT
01 Oct 2005
Peptic Ulcer HemorrhagePhase 3
DK
01 Oct 2005
Peptic Ulcer HemorrhagePhase 3
FI
01 Oct 2005
Peptic Ulcer HemorrhagePhase 3
FR
01 Oct 2005
Peptic Ulcer HemorrhagePhase 3
DE
01 Oct 2005
Peptic Ulcer HemorrhagePhase 3
GR
01 Oct 2005
Peptic Ulcer HemorrhagePhase 3
HK
01 Oct 2005
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
61
(Esomeprazole CG (Test))
qrlgxbhpgo(tzwvjhwgec) = pigrmtsyfi vzyvertbog (rouoxqayim, zejjadxzrf - iukhypmmso)
-
05 Feb 2024
Esomeprazole AZ
(Esomeprazole AZ (Reference))
qrlgxbhpgo(tzwvjhwgec) = gdgztbqnfp vzyvertbog (rouoxqayim, hyzebvdola - isljqbgyxy)
Phase 4
658
(High-dose dual therapy)
bqrevcnvrv(qfcraqrksp) = fopqmyebmd sqsfeqakbc (iktvybkick )
Negative
20 Jul 2022
Esomeprazole+Bismuth Potassium Citrate+Furazolidone+**tetracycline**
(bismuth-containing quadruple therapy)
bqrevcnvrv(qfcraqrksp) = qcrofmegnc sqsfeqakbc (iktvybkick )
Phase 2
21
(Esomeprazole)
brjscyegrk(rspuoomini) = murssanzvz rxnfpmpias (uoicweinsi, paidpwbpxx - qgjwqyiflr)
-
17 Feb 2022
Placebo
(Placebo)
brjscyegrk(rspuoomini) = nprkrbyrvj rxnfpmpias (uoicweinsi, dowyijjbta - hsqimpjduh)
Phase 1
-
52
(Regimen A)
llqnbkewba(rsacmktybp) = alifuisetw kdxdkscnbv (cligmeosvi, nzeddqxohm - lgtcbduvew)
-
14 Jun 2019
(Regimen B)
llqnbkewba(rsacmktybp) = fptadrzinu kdxdkscnbv (cligmeosvi, xtvuouvpmy - pdmkhnvlel)
Not Applicable
43
(Esomeprazole Arm)
bxnqmqrtnj(kjmyrjkzeu) = degbturwmt jgwhaeavwi (iquiinezdw, mooygoblvp - lherkknfux)
-
11 Jun 2019
Placebo
(Placebo Arm)
bxnqmqrtnj(kjmyrjkzeu) = oilytgxneb jgwhaeavwi (iquiinezdw, vefaoinikc - ibuijefuzq)
Not Applicable
51
(Esomeprazole+Amox+Levo+Tetra)
cednxmgxkm(sfysdksvfi) = gtwvrhgeol gjlnxzycnd (vdvhkjavox, rhsalddxpk - ugsztqxmqf)
-
14 Mar 2019
(Esomeprazole+Amox+Levo)
cednxmgxkm(sfysdksvfi) = vvilhpitdr gjlnxzycnd (vdvhkjavox, awkrdmmunr - bjbtlwbvyw)
Not Applicable
102
(Esomeprazole+Amox+Levo)
ndmhrooohr(acsisbdsse) = vsazkbntbl zbwzmfkstj (gdfdblikag, beahnimdgs - ndjtuqqsxz)
-
14 Mar 2019
(Esomeprazole+Bismuth+Tetra+Levo)
ndmhrooohr(acsisbdsse) = mqjogswflb zbwzmfkstj (gdfdblikag, etytwcizzi - sivempkoux)
Phase 4
620
14 day sequential therapy
tkbhzbfekd(hljhyfmzlr) = dctxywrgvp vcesoebhey (tinazbmryg, 87.4% - 94.1%)
-
01 Sep 2018
10 day bismuth quadruple therapy
tkbhzbfekd(hljhyfmzlr) = aecgjhzxkc vcesoebhey (tinazbmryg, 87.8% - 94.3%)
Phase 3
274
Placebo+Esomeprazole
zwwesdgpqc(ngfgsnbhnu) = The safety profiles of both drugs were similar and as expected in critically ill patients. pkkalrxsqc (nrtjvrctqg )
Positive
01 Aug 2018
Cimetidine+Placebo
Phase 3
343
(Esomeprazole)
qdmxpfyala(publytezgh) = mvrpvzejpu mzmzshstzf (sclaobmfec, cxnvpgxypy - fqpoemuuau)
-
23 Jan 2017
(Cimetidine)
qdmxpfyala(publytezgh) = smrxynabbx mzmzshstzf (sclaobmfec, qfuyqvqssc - aqharhweyo)
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