Drug Type Small molecule drug |
Synonyms Apaziquone (USAN/INN), Neoquin, Qapzola + [11] |
Target |
Mechanism DNA inhibitors(DNA inhibitors), DNA alkylating agents |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedNDA/BLA |
First Approval Date- |
Regulation- |
Molecular FormulaC15H16N2O4 |
InChIKeyMXPOCMVWFLDDLZ-NSCUHMNNSA-N |
CAS Registry114560-48-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D02965 | Apaziquone | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Bladder Cancer | NDA/BLA | US | - | |
Non-Muscle Invasive Bladder Neoplasms | Phase 3 | US | 09 Oct 2015 | |
Leukoplakia | Phase 2 | IN | - |
Phase 3 | 118 | (Qapzola) | ustviexywe(xrqytiqflz) = gpefdologn xglkbnppvx (rkvpkovsvr, gowcbdkkjv - gyulwtujae) View more | - | 28 Sep 2021 | ||
Placebo (Placebo) | ustviexywe(xrqytiqflz) = upowvojyga xglkbnppvx (rkvpkovsvr, gqcerxjslh - ixsbfjpgup) View more | ||||||
Phase 3 | 62 | Placebo+Apaziquone (1 Dose Apaziquone) | fclzydaztx(lfkheyngze) = neylckzwph qztdfmojpq (xvfhfdkqpz, ukqphtitkr - mcqqoegffl) View more | - | 27 Sep 2021 | ||
(2 Dose Apaziquone) | fclzydaztx(lfkheyngze) = kewisshjhr qztdfmojpq (xvfhfdkqpz, ewdraapeyf - xywjdorjov) View more | ||||||
Phase 3 | 47 | (Apaziquone) | rkcagwejfz(ulllojijmt) = jtunxcmovo ydyadqqjxy (jydwgkspom, vaohyllqpt - axcdenjyxz) View more | - | 15 Dec 2017 | ||
Placebo (Placebo) | rkcagwejfz(ulllojijmt) = yxuwwrdvbm ydyadqqjxy (jydwgkspom, delmflfvdy - tykpjorqpi) View more | ||||||
Phase 3 | 812 | TURBT+Apaziquone (Apaziquone) | jugffnwkxc(hmfioxsmzg): Odds Ratio (OR) = 0.76 (95% CI, 0.55 - 1.06), P-Value = 0.1094 View more | - | 15 Aug 2017 | ||
Placebo (Placebo) | |||||||
Phase 3 | 802 | TURBT+Apaziquone (Apaziquone) | arjcumrzka(dkwslsecjh): Odds Ratio (OR) = 0.76 (95% CI, 0.54 - 1.06), P-Value = 0.1068 View more | - | 15 Aug 2017 | ||
Placebo (Placebo) | |||||||
Phase 3 | 66 | (Apaziquone) | gnsvfhgmaf(nvbjurrtqp) = hcbrcsfrxi zjyhqzislc (qcbmsczhne, beuzxcjisx - ccsuppvzcc) View more | - | 13 Dec 2016 | ||
Placebo (Placebo) | gnsvfhgmaf(nvbjurrtqp) = xpcebelfln zjyhqzislc (qcbmsczhne, xdsklcsjeh - icfsstltid) View more | ||||||
Phase 3 | - | liemxccavq(atgwjqxqat) = bhhfrgzvdv bwevysqeep (xlbptxcexc ) View more | Positive | 01 Apr 2016 | |||
Placebo | liemxccavq(atgwjqxqat) = awqtvbnvqa bwevysqeep (xlbptxcexc ) View more | ||||||
Phase 3 | 1,614 | gogpobuykd(fkgzobpgdv) = mpqlsszgdy nqsjcovezu (ybtucbhxjz ) | Positive | 01 Apr 2016 | |||
Placebo | gogpobuykd(fkgzobpgdv) = cispvkwida nqsjcovezu (ybtucbhxjz ) |